DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tet and Tet2

DIOPT Version :9

Sequence 1:NP_001261344.1 Gene:Tet / 38347 FlyBaseID:FBgn0263392 Length:2921 Species:Drosophila melanogaster
Sequence 2:NP_001333665.1 Gene:Tet2 / 214133 MGIID:2443298 Length:1920 Species:Mus musculus


Alignment Length:2553 Identity:578/2553 - (22%)
Similarity:883/2553 - (34%) Gaps:822/2553 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   454 LQHG-----QPHPIPMGMHTPTSYDGNNSNNSYPQAAGGGSGSHTPH---------------TTT 498
            ||:|     :|||...|   .|.:..:.|........|..|...:||               .|.
Mouse    35 LQNGSPLAERPHPEVNG---DTKWQSSQSCYGISHMKGSQSSHESPHEDRGYSRCLQNGGIKRTV 96

  Fly   499 TQPTPTTTTPVKVEKLLQSPIARLEARKKERRKQRPNSLESSAESEASGMDVDPSNPGQVDAVSS 563
            ::|:.:...|.|:.||.|.  |:.|:...|..::| |..:||.:...||:. |...|     |:|
Mouse    97 SEPSLSGLHPNKILKLDQK--AKGESNIFEESQER-NHGKSSRQPNVSGLS-DNGEP-----VTS 152

  Fly   564 TANFKSPLSALGMGDSNDANASGCDKQDYGRRHHLPPPTLNHPPMTLPPPTITITPTTHNHNHQN 628
            |..                .:||.|                            ..||.:.:..:.
Mouse   153 TTQ----------------ESSGAD----------------------------AFPTRNYNGVEI 173

  Fly   629 HNHNHSNDNNSSSCSLFQSKKKRKRCGECVGCQRKDNC-GECAPCRNDKSHQICKQRRCEKLTEK 692
            ...|........|.:|.::|......|..|....::|. ||                    |.||
Mouse   174 QVLNEQEGEKGRSVTLLKNKIVLMPNGATVSAHSEENTRGE--------------------LLEK 218

  Fly   693 KE--PKAKTIVFGADGQPVRPDSKRGRGKGKSSGSGNGTVNATGIAAGNGTPTTGSRARKNSTKA 755
            .:  |...:|...:....|...|.:                 ..|...:..|       :.|..:
Mouse   219 TQCYPDCVSIAVQSTASHVNTPSSQ-----------------AAIELSHEIP-------QPSLTS 259

  Fly   756 NKLNAAAASATSPRLSPVPAATLLP------QQSPNTTSATGNLQQQQQQQQQQYQ------QHQ 808
            .::|.:..|  |.:|.|.|||.:..      ...|.....|...|:.:.||:....      :::
Mouse   260 AQINFSQTS--SLQLPPEPAAMVTKACDADNASKPAIVPGTCPFQKAEHQQKSALDIGPSRAENK 322

  Fly   809 QLLSQQQLLSQQQQQYQQPQQQQQHFQQQQQQHLQQQHAQQQHLPQQQHQITAQIQTMKDQPQQP 873
            .:....:|.:::             :.....::||..|...:...:|:....|..:.....|:..
Mouse   323 TIQGSMELFAEE-------------YYPSSDRNLQASHGSSEQYSKQKETNGAYFRQSSKFPKDS 374

  Fly   874 MAPMAFYPTWQADPSQG-WQNQFIQQIPQNTPAITSLNSLDFQTQSYAYPSNG---YVQSGLGFD 934
            ::|....|     |||. ...:.:.|.|.....  :||.:..: :.:.||:..   .::.|    
Mouse   375 ISPTTVTP-----PSQSLLAPRLVLQPPLEGKG--ALNDVALE-EHHDYPNRSNRTLLREG---- 427

  Fly   935 PNYGRSPYAAPVQRYDFQSQQLSTAPSAINQVGLQSVAGFAPSYAGQVSAAPVPPSQQQQQQQQQ 999
                         :.|.|.:  :::..::|           ||.     ..|.||....:|.|..
Mouse   428 -------------KIDHQPK--TSSSQSLN-----------PSV-----HTPNPPLMLPEQHQND 461

  Fly  1000 QQQQHLGADLNKTMSGNDTPGYPR-VSSVPPRSLNCNGYSG---DYSGSPATNSNSNNNSSSNTS 1060
                          .|:.:|...| :|......|..:|:||   ::|.....:........:|..
Mouse   462 --------------CGSPSPEKSRKMSEYLMYYLPNHGHSGGLQEHSQYLMGHREQEIPKDANGK 512

  Fly  1061 NTNNSNASNNNATTVVSGGTTTPAPPPTVVAQPASSPMQPPN--QAVPQSPTRS----NMLQQQ- 1118
            .|..|                       |.|.|....::.||  :|:.|:..:.    ::|..| 
Mouse   513 QTQGS-----------------------VQAAPGWIELKAPNLHEALHQTKRKDISLHSVLHSQT 554

  Fly  1119 ----QQQHQSPTGN-----GLQ--PYVAPQQQQQQQQQQHL------SSPPMQDWNWQQQQQQQQ 1166
                |...:..|||     |.|  ||:....|.:|:.|.:.      .||.|.|.:.|.|:...|
Mouse   555 GPVNQMSSKQSTGNVNMPGGFQRLPYLQKTAQPEQKAQMYQVQVNQGPSPGMGDQHLQFQKALYQ 619

  Fly  1167 SL------GGEGYAQG---ERLHLNTRIKSMIMRKSDPKDPPPDLQQQPQQVQQQQQTGHFLSYS 1222
            ..      ..|.:.|.   .:.|...|:           :|..| :...||..:.|:...||.::
Mouse   620 ECIPRTDPSSEAHPQAPSVPQYHFQQRV-----------NPSSD-KHLSQQATETQRLSGFLQHT 672

  Fly  1223 HHLRPEAALSANGPSSATPTHPLPNLQQQQQQVQQVQQVQQQQ-----------QQQQAVGGQVA 1276
                |:...|.. |:|.....|....||||||:|:..:.|..|           |::.:..||:.
Mouse   673 ----PQTQASQT-PASQNSNFPQICQQQQQQQLQRKNKEQMPQTFSHLQGSNDKQREGSCFGQIK 732

  Fly  1277 AEP---IGGGGDHIWKPHHANSFKKPSVVSGYPASQDAQLQLQ-LQQHQPGQHTTINHSVDPPVV 1337
            .|.   :|            |.:.|.|....:..:|....|:| :.::.|.......:|.:..::
Mouse   733 VEESFCVG------------NQYSKSSNFQTHNNTQGGLEQVQNINKNFPYSKILTPNSSNLQIL 785

  Fly  1338 PPQQHPPVAAAQPKKSRSRSKASRAAAAAAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPH 1402
            |.....|....:.......||.|...                              :..|.|:  
Mouse   786 PSNDTHPACEREQALHPVGSKTSNLQ------------------------------NMQYFPN-- 818

  Fly  1403 AAGGPPPGQDYHSQYIKTEPGLLGPPQPNKMEGYERNYQ--------NFIQYADFCQNDGQGQPV 1459
               ...|.||.|..:   :.....|.|.:.::|.:...|        ...|......|:.:..||
Mouse   819 ---NVTPNQDVHRCF---QEQAQKPQQASSLQGLKDRSQGESPAPPAEAAQQRYLVHNEAKALPV 877

  Fly  1460 QQHHGH-----GQQDYAGYHHNSAYYGAGASSFQQNFQQNFVPGYQHSTYGARGKPPANQPHQIH 1519
            .:..|.     .|:|  ...|.:..:.......||..||                   :||    
Mouse   878 PEQGGSQTQTPPQKD--TQKHAALRWLLLQKQEQQQTQQ-------------------SQP---- 917

  Fly  1520 GHGQSLMELDRKPDTNSIIPLPTNYEKDIPAYPIPPHRYALGHGAPPHLS----HHGMLEPKIED 1580
            ||.|.|..:..:|     :..|::|.     ||:.|.:..:.......:|    .:|..:..||.
Mouse   918 GHNQMLRPIKTEP-----VSKPSSYR-----YPLSPPQENMSSRIKQEISSPSRDNGQPKSIIET 972

  Fly  1581 MGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTRPPTAEHLKDGTCLGLGIQPKEELIDEDELIDT 1645
            |..  |...:...           |.|........:.:|:|..|    .||..|.        :.
Mouse   973 MEQ--HLKQFQLK-----------SLCDYKALTLKSQKHVKVPT----DIQAAES--------EN 1012

  Fly  1646 HGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKINPMFDTTDRLEKGNKTEIPECECFQSDKNPPE 1710
            |....:|                  ...|....:.:.|.::....|.:::..:||....||   :
Mouse  1013 HARAAEP------------------QATKSTDCSVLDDVSESDTPGEQSQNGKCEGCNPDK---D 1056

  Fly  1711 PGTYYTHLGTASSLMDLRREFEERCNLTGRQLRIEKIVYTGKEGKTSQGCPVAKWVIRRADLEEK 1775
            ...||||||....:..:|...|||....|:.:||||::|||||||:|||||:||||.||:..|||
Mouse  1057 EAPYYTHLGAGPDVAAIRTLMEERYGEKGKAIRIEKVIYTGKEGKSSQGCPIAKWVYRRSSEEEK 1121

  Fly  1776 ILVVVKKRPGHRCIAAYIVVCMVAWDGMPRLEADNAYKNLIPKLNKYGLPTTRRCATNE------ 1834
            :|.:|:.||.|.|..|.:|:.::.|||:|:|.|...|..|...|.|.|:.|.|||:.||      
Mouse  1122 LLCLVRVRPNHTCETAVMVIAIMLWDGIPKLLASELYSELTDILGKCGICTNRRCSQNETKKKQS 1186

  Fly  1835 --NRTCACQGLDPESSGASYSFGCSWSMYYNGCKYARSKTVRKFRL--SVKSEEAAIEDHMNLIA 1895
              :|.|.|||.:||:.|||:||||||||||||||:||||..|||||  :...||..:..|:..:|
Mouse  1187 PPSRNCCCQGENPETCGASFSFGCSWSMYYNGCKFARSKKPRKFRLHGAEPKEEERLGSHLQNLA 1251

  Fly  1896 TLLAPVFKQVCPRSYDNQTKYEHEASDCRLGLEPGKPFSGVTACLDFCAHSHRDLHNMQDGCTVH 1960
            |::||::|::.|.:|:||.::||:|.||.|||:.|:|||||||||||.||||||..||.:|.||.
Mouse  1252 TVIAPIYKKLAPDAYNNQVEFEHQAPDCCLGLKEGRPFSGVTACLDFSAHSHRDQQNMPNGSTVV 1316

  Fly  1961 VALLKPGNRDT-RLPDDEQFHVLPLYTMDGTDEFESVEGQRDKHRTGAVQMLDKFPCE--VRVRS 2022
            |.|.:..||:. ..|:||||||||:|.:...|||.|.|||..|.|.|::::|..|...  :|:..
Mouse  1317 VTLNREDNREVGAKPEDEQFHVLPMYIIAPEDEFGSTEGQEKKIRMGSIEVLQSFRRRRVIRIGE 1381

  Fly  2023 TPLIPCRRHGKKRKDGDEAAPPDGDQDAVGDANSQSSSSNGAQSQTQANNQQSSPPALGTAHIK- 2086
            .|. .|::..:.:|...:.|           |..:||..| ..|:|:.....|        |.| 
Mouse  1382 LPK-SCKKKAEPKKAKTKKA-----------ARKRSSLEN-CSSRTEKGKSSS--------HTKL 1425

  Fly  2087 KENGNGVNANGASSKSKGKGKSNQSNNSSASTPGSAP--PSTPSPRCQTPVTNNPSPAGSAFSTP 2149
            .||.:.:....|..:..|...............|..|  |..|.|:.||  |..|.|       .
Mouse  1426 MENASHMKQMTAQPQLSGPVIRQPPTLQRHLQQGQRPQQPQPPQPQPQT--TPQPQP-------Q 1481

  Fly  2150 PVHGSNANPQSNGGQGTGNQPGQLMSSNSSLMNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQ 2214
            |.|....|.||.|...:|                                               
Mouse  1482 PQHIMPGNSQSVGSHCSG----------------------------------------------- 1499

  Fly  2215 TASYIDSRNYYGQWPTPHAPMGMQAQVGGLGGGGPGGTVAGVPPLTPSTPTAQPQLGVPPATSIA 2279
                  |.:.|.:.||||:|....|....:.|.                                
Mouse  1500 ------STSVYTRQPTPHSPYPSSAHTSDIYGD-------------------------------- 1526

  Fly  2280 GGTTTGAPTGALPATAPPTATPTQLETSNGY-GPGNYQTLVSNPASNLTNPGGVTTEVQQQHQQA 2343
                          |......||....|..| .|.||.    ||...|.|         |.:|.|
Mouse  1527 --------------TNHVNFYPTSSHASGSYLNPSNYM----NPYLGLLN---------QNNQYA 1564

  Fly  2344 QQQSALTGGVGP----GGLPVVGGAPGDLKGRLVSEENPDSTTLVNHHH-HHHNLTESKLTALTA 2403
                       |    |.:||..|:|      .:...:|.:.:...|.: :..:||..       
Mouse  1565 -----------PFPYNGSVPVDNGSP------FLGSYSPQAQSRDLHRYPNQDHLTNQ------- 1605

  Fly  2404 MQPMTNLAPLTTSHHPQEGFVKPKPPPSDYTAQYTAQYPNNYQMYPPPPPPPHSAYSAYDAYQNM 2468
                 ||.|:.|.|  |:.|       .|..::|.:....|.|.            .|:.....:
Mouse  1606 -----NLPPIHTLH--QQTF-------GDSPSKYLSYGNQNMQR------------DAFTTNSTL 1644

  Fly  2469 NYNYGYHQAYSPYGMYPQQTPPPTP---------------PPPSPNWNMYGHHQTGSVNSGYGSA 2518
            ..|..:...:|||         |||               ..|..::....||........|   
Mouse  1645 KPNVHHLATFSPY---------PTPKMDSHFMGAASRSPYSHPHTDYKTSEHHLPSHTIYSY--- 1697

  Fly  2519 NPAAGAGSLISSHGSVASAGVGLQKAMVPVPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQQQQ 2583
             .||.:|| .|||.                   .|:::...:.....:                 
Mouse  1698 -TAAASGS-SSSHA-------------------FHNKENDNIANGLSR----------------- 1724

  Fly  2584 QVQQLQQEAPQTILPDLSNGQTNSDTVATPTPTGDSSSNDAGPGNPGAGNQAPASGAGAATTAPP 2648
                        :||..::.:|.|......:.||.|..           .|...||..||.    
Mouse  1725 ------------VLPGFNHDRTASAQELLYSLTGSSQE-----------KQPEVSGQDAAA---- 1762

  Fly  2649 IASPGSTNSTKIEPIGEVAEINENIEAFQDPQMGGVAIALNHGSVLIECAKHEMHATTAVRRPDR 2713
                          :.|:...:::...||||.:||||||..|||:||||||.|:||||.|..|||
Mouse  1763 --------------VQEIEYWSDSEHNFQDPCIGGVAIAPTHGSILIECAKCEVHATTKVNDPDR 1813

  Fly  2714 HHPTRMTLIFYQHRNLNRCRHGIDEWEEKMRVKKINTDLDNKAKEERERLIKKAAGEDMDELDED 2778
            :||||::|:.|:|:||...:|.:..||.||.         .||::|.|      .|         
Mouse  1814 NHPTRISLVLYRHKNLFLPKHCLALWEAKMA---------EKARKEEE------CG--------- 1854

  Fly  2779 ALMQDEPVPIKKESSANGQQLKNGASG-SKKKKSSDSKKSQANEQSKN-----EKVALHAPTLTT 2837
                                 |||:.. |:|......|:.....|..:     :.:|.:..::||
Mouse  1855 ---------------------KNGSDHVSQKNHGKQEKREPTGPQEPSYLRFIQSLAENTGSVTT 1898

  Fly  2838 TSWTTLFPTHPCVVSGKY 2855
            .|..|..|.....|:|.|
Mouse  1899 DSTVTTSPYAFTQVTGPY 1916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TetNP_001261344.1 zf-CXXC 646..686 CDD:251032 6/40 (15%)
Tet_JBP 1857..>1990 CDD:289611 76/135 (56%)
Tet_JBP <2676..2727 CDD:289611 34/50 (68%)
Tet2NP_001333665.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..86 13/53 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..166 20/106 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 340..359 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 367..388 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..470 12/72 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..723 14/50 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 832..862 4/29 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 907..966 18/91 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1009..1052 8/68 (12%)
Tet_JBP 1048..>1373 CDD:394797 167/327 (51%)
Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q6N021 1211..1224 11/12 (92%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1387..1422 9/54 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1522 25/131 (19%)
Tet_JBP <1764..1855 CDD:394797 48/135 (36%)
2-oxoglutarate binding. /evidence=ECO:0000250|UniProtKB:Q6N021 1818..1820 1/1 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q6N021 1824..1826 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1850..1879 9/64 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 272 1.000 Domainoid score I1796
eggNOG 1 0.900 - - E1_28N65
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 499 1.000 Inparanoid score I1355
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002939
OrthoInspector 1 1.000 - - otm42457
orthoMCL 1 0.900 - - OOG6_104768
Panther 1 1.100 - - O PTHR23358
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.950

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