DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tet and Tet3

DIOPT Version :9

Sequence 1:	NP_001261344.1	Gene:	Tet / 38347	FlyBaseID:	FBgn0263392	Length:	2921	Species:	Drosophila melanogaster
Sequence 2:	NP_001334242.1	Gene:	Tet3 / 194388	MGIID:	2446229	Length:	1803	Species:	Mus musculus

Alignment Length:	2396	Identity:	571/2396 - (23%)
Similarity:	824/2396 - (34%)	Gaps:	843/2396 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   648 KKKRKRCGECVGCQRKDNCGECAPCRNDKSHQICKQRRCEKLTEK----KEPKAKTIVFGADGQP 708
            :|||||||.|..|:|.:|||.|..|.|.::|||||.|:||.|.:|    ||
Mouse    51 RKKRKRCGTCDPCRRLENCGSCTSCTNRRTHQICKLRKCEVLKKKAGLLKE-------------- 101

  Fly   709 VRPDSKRGRG---KGKSSGSGNGTVNATGIAAG--NGTPTTGSRARKNSTKANKLNAAAASATSP 768
            |..:::.|.|   :|.:..:|:......|...|  :..|.....:|:.||....:|.|...|...
Mouse   102 VEINAREGTGPWAQGATVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSTSGAPVNGAREPAGPG 166

  Fly   769 RLSPVPAATLLPQQSPNTTSATGNLQQQQQQQQQQ---YQQHQQLLSQQQLLSQQQQQY------ 824
            .|.  .|......|.|:..:|:|.....:.:....   :....:.:|....||.:..:.
Mouse   167 LLG--AAGPWRVDQKPDWEAASGPTHAARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMS 229

  Fly   825 -------QQPQQQQQHFQQQQQQHLQQQHAQQQH-------------LPQQQHQITAQIQTMKDQ 869
                   :.|:.:......:....||...|..:|             .|.....:..:|::|..:
Mouse   230 REAGSNGRGPRPESCSEGSEDLDTLQTALALARHGMKPPNCTCDGPECPDFLEWLEGKIKSMAME 294

  Fly   870 PQQ--PMAPMAFYPTWQADPSQGWQNQFI-QQIPQNTPAITSLNSLDFQTQSYAYPSNGYVQSGL 931
            ..|  |..|.|..|:....|:...:...: .::|| .|.:..| .|.....|.|...|..:|:.:
Mouse   295 GGQGRPRLPGALPPSEAGLPAPSTRPPLLSSEVPQ-VPPLEGL-PLSQSALSIAKEKNISLQTAI 357

  Fly   932 GFD-----------PNYGRSPYAAPVQRYDFQSQQLS-TAPSAINQVGLQSVAGFAPSYAGQVSA 984
            ..:           |::..|..:.|:      .:.|| :||....|..|:     |||:
Mouse   358 AIEALTQLSSALPQPSHSTSQASCPL------PEALSPSAPFRSPQSYLR-----APSW------ 405

  Fly   985 APVPPSQQQQQQQQQQQQQHLGADLNKTMSGNDTPGYPRVSSVPPRSLNCNGYSGDYSGSPATNS 1049
             ||.|.::...                  ...|:|.:|..:   ||......:..|  ..|||..
Mouse   406 -PVVPPEEHPS------------------FAPDSPAFPPAT---PRPEFSEAWGTD--TPPATPR 446

  Fly  1050 NS----NNNSSSNTSNTNNSNASNNNATTVVSGGTTTPAPPPTVVAQPASSPMQPPNQAVPQSPT 1110
            ||    ..:............::::...:|.......|..|...|..|:|||...|:   |.|..
Mouse   447 NSWPVPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPVPS---PISQR 508

  Fly  1111 RSNMLQQQQQQHQSPTGNGLQPYVAPQQQQQQQQQQHLSSPPMQD-----WNWQQQQQQQQSLGG 1170
            .:.:|..:...||. ....||.::..::....:|.|..|.|...:     | |..
Mouse   509 EAPLLSSEPDTHQK-AQTALQQHLHHKRNLFLEQAQDASFPTSTEPQAPGW-WAP---------- 561

  Fly  1171 EGYAQGERLHLNTRIKSMIMRKSDPKDPPPDLQQQPQQVQQQQQTGHFLSYSHHLRPEAALSANG 1235
                                 ...|...|||  :.|::.:::..|                .|.|
Mouse   562 ---------------------PGSPAPRPPD--KPPKEKKKKPPT----------------PAGG 587

  Fly  1236 PSSATPTHPLPNLQQQQQQVQQVQQVQQQQQQQQAVG-GQVAAEPIGGGGDHIWKPHHANSFKKP 1299
            |..|..|  .|.::...::..|:::.:.:..|...:. .|:..|.:                 ||
Mouse   588 PVGAEKT--TPGIKTSVRKPIQIKKSRSRDMQPLFLPVRQIVLEGL-----------------KP 633

  Fly  1300 SVVSGYPASQDAQLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQPKKSRSRSKASRAAA 1364
            ....|     .|.|..||             ||.||                       ||:.||
Mouse   634 QASEG-----QAPLPAQL-------------SVPPP-----------------------ASQGAA 657

  Fly  1365 AAAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQDYH--SQYIKTEPGLLG- 1426
            :.:.|.....|                |..|.:.|.|......||.|:..  |..:..:.|..|
Mouse   658 SQSCATPLTPE----------------PSLALFAPSPSGDSLLPPTQEMRSPSPMVALQSGSTGG 706

  Fly  1427 --PPQPNKMEGYERNYQNFIQYADFCQNDGQGQPVQQHHGHGQQDYAGYHHNSAYYGAGASSFQQ 1489
              ||..:|:|...|.::     |:|..:.|
Mouse   707 PLPPADDKLEELIRQFE-----AEFGDSFG----------------------------------- 731

  Fly  1490 NFQQNFVPGYQHSTYGARGKPPANQPHQIHGHGQSLMELDRKPDTNSIIPL--PTNYEKDIPAYP 1552
                  :||           ||:                         :|:  |.|....:||
Mouse   732 ------LPG-----------PPS-------------------------VPIQEPENQSTCLPA-- 752

  Fly  1553 IPPHRYALGHGAPPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTRPPT- 1616
             |...:|.  .:|..:        |||..|.:.......:...||            |....||
Mouse   753 -PESPFAT--RSPKKI--------KIESSGAVTVLSTTCFHSEEG------------GQEATPTK 794

  Fly  1617 AEHLKDGTCLGLGIQPKEELIDEDELIDTHGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKINPM 1681
            ||:....|..|....|.:.|       ||                                  |.
Mouse   795 AENPLTPTLSGFLESPLKYL-------DT----------------------------------PT 818

  Fly  1682 FDTTDRLEKGNKTEIPECECFQSDKNPPEPGTYYTHLGTASSLMDLRREFEERCNLTGRQLRIEK 1746
            ....|...|..::|.|.|:|.:......| |.||||||:..::..:|...|:|....|:.:||||
Mouse   819 KSLLDTPAKKAQSEFPTCDCVEQIVEKDE-GPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEK 882

  Fly  1747 IVYTGKEGKTSQGCPVAKWVIRRADLEEKILVVVKKRPGHRCIAAYIVVCMVAWDGMPRLEADNA 1811
            ::|||||||:|:|||:|||||||..||||:|.:|:.|.||.|..|.||:.::||:|:||...|..
Mouse   883 VIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTL 947

  Fly  1812 YKNLIPKLNKYGLPTTRRCATNENRTCACQGLDPESSGASYSFGCSWSMYYNGCKYARSKTVRKF 1876
            |:.|...|.|||.||:|||..|::|||||||.||.:.|||:|||||||||:||||||||||.|||
Mouse   948 YQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKF 1012

  Fly  1877 RLSVKS--EEAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEHEASDCRLGLEPGKPFSGVTAC 1939
            ||:..:  ||..:.:....:||.:||::|::.|::|.||...|..|.||||||:.|:||||||||
Mouse  1013 RLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVTAC 1077

  Fly  1940 LDFCAHSHRDLHNMQDGCTVHVALLKPGNRDT-RLPDDEQFHVLPLYTMDGTDEFESVEGQRDKH 2003
            :|||||:|:|.||:.:||||...|.|..||.. ::|:|||.||||||.|..||||.|.|.|..|.
Mouse  1078 MDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKV 1142

  Fly  2004 RTGAVQMLDKFPCEVRVRSTPLIPCRRH---------GKKRKDGDEAAPPDG-DQDAV---GDAN 2055
            .:||:|:|..||.|||....|...||:.         .||:...::.:.|:. .|:|:   |...
Mouse  1143 SSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKLQKEKLSTPEKIKQEALELAGVTT 1207

  Fly  2056 SQSSSSNGAQSQTQANNQQSSPPALGTA---HIK--KENGNGVNANGASSKSKGKGKSNQSNNSS 2115
            ....|..|..|      |||..|:|...   |..  |.:||.|                   ..|
Mouse  1208 DPGLSLKGGLS------QQSLKPSLKVEPQNHFSSFKYSGNAV-------------------VES 1247

  Fly  2116 ASTPGSAPPSTPSPRCQTPVTNNPSPAGSAFSTPPVHGSNANPQSNGGQGTGNQPGQLMSSNSSL 2180
            .|..||..||            :|....|.:|   .|...|            ||| |.|.|.
Mouse  1248 YSVLGSCRPS------------DPYSMSSVYS---YHSRYA------------QPG-LASVNG-- 1282

  Fly  2181 MNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQTASYIDSRNYYGQWPT-----PHAPMGMQAQ 2240
                                    ..|.|:        :.|..||| :|:     |...:|..|
Mouse  1283 ------------------------FHSKYT--------LPSFGYYG-FPSSNPVFPSQFLGPSA- 1313

  Fly  2241 VGGLGGGGPGGTVAGVPPLTPSTPTAQPQLGVPPATSIAGGTTTGAPTGALPATAPPTATPTQLE 2305
               .|.||.||:....|.|
Mouse  1314 ---WGHGGSGGSFEKKPDL---------------------------------------------- 1329

  Fly  2306 TSNGYGPGNYQTLVSNPASNLTNPGGVTTEVQQQHQQAQQQSALTGGVGPGGLPVVGGAP-GDLK 2369
                           :...|..|                              |..|||. .:|.
Mouse  1330 ---------------HALHNSLN------------------------------PAYGGAEFAELP 1349

  Fly  2370 GRLVSEENPDSTTLVNHHHHHHNLTESKLTALTAMQPMTNLAPLTTSHHPQEGFVKPKPPPSDYT 2434
            |:.|:.:|            ||.:                      .||.|..:    |.|.:|.
Mouse  1350 GQAVATDN------------HHPI----------------------PHHQQPAY----PGPKEYL 1376

  Fly  2435 AQYTAQYPNNYQMYPPPPPPPHSAYSAYDAYQNMNYNYGYHQAYSPYGMYPQQTPPP-------- 2491
                  .|...|::|....|...|.|      :..||....|  .|.....|....|
Mouse  1377 ------LPKVPQLHPASRDPSPFAQS------SSCYNRSIKQ--EPIDPLTQAESIPRDSAKMSR 1427

  Fly  2492 TPPP-------PSPNWNMY------GHHQTGSVNSGYGSANP------------AAGAGSLISSH 2531
            ||.|       ||..|..|      ...:|.||...:|...|            :.||..|..||
Mouse  1428 TPLPEASQNGGPSHLWGQYSGGPSMSPKRTNSVGGNWGVFPPGESPTIVPDKLNSFGASCLTPSH 1492

  Fly  2532 GSVASAGVGLQKAMVPVPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQQQQQVQQLQQEAPQTI 2596
            ...:..|:...:.                                            ||.||...
Mouse  1493 FPESQWGLFTGEG--------------------------------------------QQSAPHAG 1513

  Fly  2597 LP---------DLSNGQ---TNSDTVATPTPTGDSSSNDAGPGNPG-----------AGNQAPAS 2638
            ..         ...||.   |.......|...|....|.|..|.||           ...:.|..
Mouse  1514 ARLRGKPWSPCKFGNGTSALTGPSLTEKPWGMGTGDFNPALKGGPGFQDKLWNPVKVEEGRIPTP 1578

  Fly  2639 GAGAATTA-----PPIAS---------------------------PGSTNSTKIEPIGEVAEINE 2671
            ||.....|     .|::|                           |.|....|.|..|...|.:|
Mouse  1579 GANPLDKAWQAFGMPLSSNEKLFGALKSEEKLWDPFSLEEGTAEEPPSKGVVKEEKSGPTVEEDE 1643

  Fly  2672 ------NIEAFQDPQMGGVAIALNHGSVLIECAKHEMHATTAVRRPDRHHPTRMTLIFYQHRNLN 2730
                  :...|.|..:||||:|..|.|:|||||:.|:||||.:::|:|.||||::|:||||:|||
Mouse  1644 EELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLN 1708

  Fly  2731 RCRHGIDEWEEKMRVKKINTDLDNKAKEERERLIKKAAGEDMDELDEDALMQDEPVPIKKESSAN 2795
            :..||:..||.||:      .|..:|::.:|...:...|:                   :|:...
Mouse  1709 QPNHGLALWEAKMK------QLAERARQRQEEAARLGLGQ-------------------QEAKLY 1748

  Fly  2796 GQQLKNGASGSKKKKSSDSKKSQANEQSKNEKVALHAPT---LTTTSWTTLFPTHP 2848
            |::.|.|.:...:.:..:.|.:....|      ||..||   :|.:|:.....|.|
Mouse  1749 GKKRKWGGAMVAEPQHKEKKGAIPTRQ------ALAMPTDSAVTVSSYAYTKVTGP 1798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tet	NP_001261344.1	zf-CXXC	646..686	CDD:251032	22/37 (59%)
		Tet_JBP	1857..>1990	CDD:289611	76/135 (56%)
		Tet_JBP	<2676..2727	CDD:289611	29/50 (58%)
Tet3	NP_001334242.1	zf-CXXC	50..89	CDD:366873	22/37 (59%)
		PHA03247	<126..461	CDD:223021	67/379 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..167		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..251		1/21 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..328		6/33 (18%)
		PHA03247	<297..760	CDD:223021	125/722 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..460		26/131 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..614		34/191 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..712		29/136 (21%)
		TET3	836..>1160	CDD:380676	176/324 (54%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:Q6N021	993..1006		11/12 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1354..1456		28/153 (18%)
		Tet_JBP	<1612..1774	CDD:394797	55/186 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1617..1639		5/21 (24%)
		2-oxoglutarate binding. /evidence=ECO:0000250\|UniProtKB:Q6N021	1696..1698		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q6N021	1702..1704		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I1796
eggNOG	1	0.900	-	-		E1_28N65
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002939
OrthoInspector	1	1.000	-	-		otm42457
orthoMCL	1	0.900	-	-		OOG6_104768
Panther	1	1.100	-	-	O	PTHR23358
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900