DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tet and tet2

DIOPT Version :9

Sequence 1:	NP_001261344.1	Gene:	Tet / 38347	FlyBaseID:	FBgn0263392	Length:	2921	Species:	Drosophila melanogaster
Sequence 2:	XP_005159960.1	Gene:	tet2 / 101887161	ZFINID:	ZDB-GENE-090312-98	Length:	1715	Species:	Danio rerio

Alignment Length:	2251	Identity:	551/2251 - (24%)
Similarity:	815/2251 - (36%)	Gaps:	719/2251 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   781 QQSPNTTSATGNLQQQQQQQQQQY-QQHQQLLSQQQLLSQQQQQYQQPQQQQQHFQQQQ-QQHLQ 843
            :::.|.|..:..|.:....||..: .:||......::||||    :.|...|..|.|.. ....|
Zfish     4 EKTSNETEKSHILAKISATQQTDFLTKHQNGDQSPEVLSQQ----KVPANLQGIFDQSMFGMKGQ 64

  Fly   844 QQHAQQQHLPQQQHQITAQIQTMKDQPQQPMAPMAFYPTWQADPSQGWQNQFIQQIPQNTPA--I 906
            .:||..:......|    |.:|:.:..:.|.       .|  |.|:......::..|::..|  :
Zfish    65 MKHALSEQALLDFH----QTKTLVNGNENPR-------IW--DKSEAGMENRLEVFPKHNKAGDL 116

  Fly   907 T--SLNSLDFQTQSYAYPSNGYVQSGLGFDPNYGRSPYAAPVQRYDFQSQQLSTAPSAINQVGLQ 969
            |  .:|........::...|..||.     || |.:                ::.||.....|..
Zfish   117 THAKINCNFTNGDLFSLSRNKQVQM-----PN-GAT----------------TSPPSVKGTTGDL 159

  Fly   970 SVAGFAPSYAGQVSAAPVPPSQQQQQQQQQQQQQHLGADLNKTMSGNDTPGY---PRVSS----- 1026
            .....:..|...||.||...|.|..|.......|       .|.|.:.|.|:   |::|:
Zfish   160 LEKTLSQYYPEHVSIAPQTNSSQVDQVTSNLPDQ-------ATSSPSFTSGFPISPQISASETLV 217

  Fly  1027 -VPPRSLNCNGYSGD-----YSGSPATNSNSNNNSSSNTSNTNNSNASNNNATTVVSGGTTTPAP 1085
             .||...|.|||:.:     ||...|.......:.|.....:...:.||..:.|||:|
Zfish   218 KAPPEVQNSNGYNPELAVNGYSSFAAEQKKPAYSLSDLPELSQKDSESNVPSQTVVNG------- 275

  Fly  1086 PPTVVAQPASSPMQPPNQAVPQSPTRSNMLQQQQQ--QHQSPTGNGLQPYVAPQQQQQQQQQQHL 1148
                     ||.:|...:|:|......||..:..|  .|.|.|   |.|..|....|..|..|
Zfish   276 ---------SSQIQEDREALPNDSECVNMFSKSNQNLSHGSYT---LPPVTAGSPSQTSQTGQ-- 326

  Fly  1149 SSPPMQDWNWQQQQQQQQSLGGEGYAQGERLHLNTRIKSMIMRKSDPKDPPPDLQQQ----PQQV 1209
                   :|.|.:..|:::       ..|.||.|.....:..:..:|:.....|..|    |.|.
Zfish   327 -------YNPQIKVPQKKT-------TDENLHGNRDFSLLQQQTHEPQAVESKLIPQACTSPSQN 377

  Fly  1210 QQQQQ-----TGHFLSYSHHLRPEAA---LSANGPSSATPT--H--------PLPNLQQQ---QQ 1253
            :...|     .|...:.|....|.:.   :..|..|::||:  |        |..|:||.   |.
Zfish   378 RNNDQDNKSKLGLEKTLSKGTDPSSQMEWIDLNSTSASTPSTEHSQMWDLFLPQTNIQQHTVPQS 442

  Fly  1254 QVQQVQQVQQQQQQQQAVGGQVAAEPIGGGGDHIWKPHHANSFKKPSVVSGYPASQDAQLQL--- 1315
            |.|.:..:.....|                         :::|...|..|....:|:.:..|
Zfish   443 QSQCINSIPPNNFQ-------------------------SHNFSNSSFPSHEIEAQENKNMLPPT 482

  Fly  1316 --------QLQQHQPGQHTTINHSVDPP--------------VVPP---QQHPPVAAAQPKKS-- 1353
                    :.||...|.|..||...:.|              ::.|   .|.||....|...|
Zfish   483 RFPHSAAPESQQRNSGMHNHINMQFNNPQHMSQKLCKNDQDQILSPSFLSQLPPTETHQQATSTF 547

  Fly  1354 -------RSRSKASRAAAAAAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQ 1411
                   |...:||              .:.||.:.:......||.|..               :
Zfish   548 SNQLPQDRQNMQAS--------------PLSRDASRSQEVEPLLKKLKT---------------E 583

  Fly  1412 DY-HSQY------IKTEPGLLGPPQ----------------------PNKMEGYERNYQNFIQYA 1447
            || ||::      |||      |.|                      |:..:..|...:..:|..
Zfish   584 DYLHSEFQMLPACIKT------PAQVQISSKAIRENFGFQDSSKSNTPSLFKEVEALTERKLQQN 642

  Fly  1448 DFC-QNDGQGQPVQQ---------HHGHGQQDYAGYHHNSAYYG-------AGASSFQQNFQQNF 1495
            ..| ||...||.:.|         |....|...:...|:.|..|       ...:.|.::|.|
Zfish   643 TECSQNISTGQQIYQQPLQHRIYNHSEFSQSLISQSQHSQASDGLQIPVRTLTKAEFHESFAQ-- 705

  Fly  1496 VPGYQHSTYGARGKPPANQPH---QIHGHGQSLMELDRKPDTNSIIPLPTNYEK------DIPAY 1551
               .|..:..:.|.....|.|   ::|     |::...:...|:|..:....:.      :|.|.
Zfish   706 ---IQRESLSSNGAQMDVQRHAALRMH-----LLQRQERQSPNNIRQMMPAIKSENCSGFEISAQ 762

  Fly  1552 PIPPHRYALGHGAPPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTRPPT 1616
            |:...|        .|..|..:|:               |.:..|..|     |.|.:...|...
Zfish   763 PMEVQR--------QHEDHTKVLK---------------AVVKQEHPP-----SSCDENQQRSIL 799

  Fly  1617 A---EHLKDGTCLGLGIQPKEELIDEDELIDTHGNGLK--PIGGV----GKAKGKQKPDEIPEIV 1672
            |   :.||.     ..:.|   :.::..|:....|.:|  ..|.|    ..|:|..|.....:..
Zfish   800 ATMEQQLKQ-----YQLSP---VFEKKSLVIKSPNKVKVEMAGAVTVISTNAEGNAKEQCKQQHF 856

  Fly  1673 VKHEKINP-------------------MFDTTDRLEKGNKTEIPECECFQSDKNPPEPGTYYTHL 1718
            ...:||.|                   :.||..:    .:.|||.|.|.:......| |.|||||
Zfish   857 TPPKKIEPGLQSFLESPMKLLNTPIKNLMDTPLK----TQYEIPSCHCVEQISERDE-GPYYTHL 916

  Fly  1719 GTASSLMDLRREFEERCNLTGRQLRIEKIVYTGKEGKTSQGCPVAKWVIRRADLEEKILVVVKKR 1783
            |:||::..:|:..|||..:||..:||||::|||||||:..|||:||||||||:.:|||||:|::|
Zfish   917 GSASNVAGIRKIMEERSGMTGSAIRIEKVLYTGKEGKSGLGCPIAKWVIRRANEDEKILVLVRER 981

  Fly  1784 PGHRCIAAYIVVCMVAWDGMPRLEADNAYKNLIPKLNKYGLPTTRRCATNENRTCACQGLDPESS 1848
            .||.|..:.:||.::.|:|:|...||..|..|...|.|:|..|.||||.||.||||||||:.::.
Zfish   982 AGHSCETSCVVVVILIWEGIPTSLADRLYMELSDTLTKHGALTNRRCALNEERTCACQGLEADAC 1046

  Fly  1849 GASYSFGCSWSMYYNGCKYARSKTVRKFRLSV--KSEEAAIEDHMNLIATLLAPVFKQVCPRSYD 1911
            |||:||||||||||||||:||||..|||:|..  ..||..||.::..:||.:|||:|::.|.:|.
Zfish  1047 GASFSFGCSWSMYYNGCKFARSKVPRKFKLLADDPKEEEKIEQNLQGLATYIAPVYKKMAPDAYS 1111

  Fly  1912 NQTKYEHEASDCRLGLEPGKPFSGVTACLDFCAHSHRDLHNMQDGCTVHVALLKPGNRDT-RLPD 1975
            ||.::|:.|.||||||:.|:||||||||||||||:||||||||.|.||...|.:..||:. ::|:
Zfish  1112 NQVEHENRAPDCRLGLKEGRPFSGVTACLDFCAHAHRDLHNMQGGSTVVCTLTREDNREIGKIPE 1176

  Fly  1976 DEQFHVLPLYTMDGTDEFESVEGQRDKHRTGAVQMLDKFPCEVRVRSTPLIPCRRHGKKRKDGDE 2040
            |||.||||||....||||.|.|.|.:|.:|||:|:|..|..:||:...|...||   :::.|...
Zfish  1177 DEQLHVLPLYKPSSTDEFGSAEAQLEKTKTGAIQVLSSFRRQVRMLPEPAKSCR---QRKLDAKR 1238

  Fly  2041 AAPPDGDQDAVGDANSQSSSSNGAQSQTQANNQQSSPPALGTAHIKKENGNGVNANGASSKSKGK 2105
            |..|:.        |:.:|.::..|...|......:|...|..:::
Zfish  1239 ANKPNN--------NTPNSKTDNTQQAKQKQTAYENPTVTGRGNMR------------------- 1276

  Fly  2106 GKSNQSNNSSASTPGSAPPSTPSPRCQTPVTNNPSPAGSAFSTPPVHGSNANPQSNGGQGTGNQP 2170
                 :|..|...|.:  .:...|:.|.|...:|:|   ::::||
Zfish  1277 -----TNLDSGHLPQA--HAGHQPQQQFPQQTHPNP---SYASPP-------------------- 1311

  Fly  2171 GQLMSSNSSLMNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQTASYIDSRNYYGQWPTPHAPM 2235
                            ...|.:|...|                                |||
Zfish  1312 ----------------FTRFPNASKPS--------------------------------TPH--- 1325

  Fly  2236 GMQAQVGGLGGGGPGGTVAGVPPLTPSTPTAQPQLGVPPATSIAGGTTTGAPTGALPATAPPTAT 2300
                                     |.||:..|.                    |.|..||
Zfish  1326 -------------------------PQTPSVDPY--------------------ASPLHAP---- 1341

  Fly  2301 PTQLETSNGYGPGNYQTLVSNPASNLTNPGGVTTEVQQQHQQAQQQSALTGGVGPGGLPVVGGAP 2365
            .:.:..||...|.: ::|..:|..|                               |....||.|
Zfish  1342 NSYINASNAPSPYS-RSLAPSPLYN-------------------------------GYQCNGGIP 1374

  Fly  2366 GDLKGRLVSEENPDSTTLVNHH-HHHHNLTESKLTALTAMQPMTNLAPLTTSHHPQEGFVKPKPP 2429
            .|                 |:| :|..||....:                  .|||..
Zfish  1375 MD-----------------NYHPYHSSNLKHPDM------------------FHPQRN------- 1397

  Fly  2430 PSDYTAQYTA--QYPNNYQMYPPPPPPPHSAYSAYDAYQNMNYNYGYHQAYSPYGMYPQQTPPPT 2492
            |.....||.|  .|..||       ||.:....|.:.|.|.|...|.|.    .|.||
Zfish  1398 PLYSEQQYNAPQHYGVNY-------PPHYGEAMATNGYGNCNMRPGIHS----MGHYP------- 1444

  Fly  2493 PPPPSPNWNMYGHHQTGSVNSGYGSANPAAGAGSLISSHGSVASAGVGLQKAMVPVPGPLHHQQQ 2557
                       |.....|.|:   .|.|.:.     ..|...|:||....|..:
Zfish  1445 -----------GFDSNMSTNA---FARPPSA-----HLHLDYAAAGNAYPKPHI----------- 1479

  Fly  2558 QVLQQQQQQQQQQQQQQQQQQQQQQQQVQQLQQEAPQTILPDLSNGQTNSDTVATPTPTGDSSSN 2622
                             .|........:..|..::.:.:  .:|..:.|..:...| |.|....|
Zfish  1480 -----------------SQNPHMFSPNLNTLSMQSHKDL--GISMHEANGISQGFP-PLGKECFN 1524

  Fly  2623 DAGPGNPGAGNQAPASGAGAATTAPPIASPGSTNSTKIEPIGEVAEINENIEAFQDPQMGGVAIA 2687
            ...|.:....|:...:.|...|..|.:      :..|.|.:...:|.|     |.||::||||:|
Zfish  1525 FNQPSSLKLPNENAHNPAVNPTQLPQV------SEKKEEDVWSDSEHN-----FLDPEIGGVAVA 1578

  Fly  2688 LNHGSVLIECAKHEMHATTAVRRPDRHHPTRMTLIFYQHRNLNRCRHGIDEWEEKMRVKKINTDL 2752
            .:|||::|||||.|:||||.|::|||:||||::|:||||:|||..:||:..||.||
Zfish  1579 PSHGSIIIECAKRELHATTPVKKPDRNHPTRISLVFYQHKNLNEAKHGLSLWEAKM--------- 1634

  Fly  2753 DNKAKEERERLIKKAAGEDMDELDEDALMQDEPVPIKKESSANGQQLKNGASGSKKKKSSDSKKS 2817
               |::.||:             :|||             ..:|.:..:..||.||.|...|:.|
Zfish  1635 ---AEKAREK-------------EEDA-------------EKHGAENTSSKSGGKKAKREHSEHS 1670

  Fly  2818 QANEQSKNEKVAL---HAPTLTTTSWTTLFPTHPCVVSGKY 2855
            :.:|....:.:.:   .:.:.||.::.:..|.....|:|.|
Zfish  1671 EPSEPPYKQFLLMLTERSMSCTTNTYVSTSPYAFTKVTGPY 1711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tet	NP_001261344.1	zf-CXXC	646..686	CDD:251032
		Tet_JBP	1857..>1990	CDD:289611	79/135 (59%)
		Tet_JBP	<2676..2727	CDD:289611	33/50 (66%)
tet2	XP_005159960.1	Tet_JBP	1055..>1191	CDD:289611	79/135 (59%)
tet2	XP_005159960.1	Tet_JBP	<1567..1618	CDD:289611	33/50 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1576
eggNOG	1	0.900	-	-		E1_28N65
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002939
OrthoInspector	1	1.000	-	-		otm24816
orthoMCL	1	0.900	-	-		OOG6_104768
Panther	1	1.100	-	-	O	PTHR23358
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.900