Protein Alignment Pgant6 and GALNT4

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_003765.2
• Gene: GALNT4 / 8693
• HGNCID: 4126
• Length: 578
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 198/535 - (37%)
• Similarity: 283/535 - (52%)
• Gaps: 80/535 - (14%)

  Fly   122 ASVKKDWHDYT---FMEKDAKRVGLGEGGKASTL---DDE--SQRDLEKRMSLENGFNALLSDSI 178
            :.::|:..|.:   :.:..|....|||.||||.|   :||  .|.:|.:|.::    |..|||.|
Human    50 SDLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAI----NIYLSDRI 110

  Fly   179 SVNRSVPDIRHPLCRKKEY-VAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDD 242
            |::|.:.|.|...|:.::: ...|||.||||.||||..|.|:|::||::..||..|:||||||||
Human   111 SLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDD 175

  Fly   243 HSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPP 307
            .|||.||..:|||||: :...||::|..:|.||:.||..||..||.:||.|||.|.|.|..||.|
Human   176 LSDRVYLKTQLETYIS-NLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEP 239

  Fly   308 LLEPIALNKRTAVCPFIDVIDHTNFHYRAQ-DEGARGAFDWE--FFYKRLPLLPEDLK-HPADPF 368
            |||.|..::...|||.||.||...|.:..| .|...|.|||.  |.:..:|....|.: ...||.
Human   240 LLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPI 304

  Fly   369 KSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRN 433
            :||.|||||||:|:::|..||.||.|:::||||..||||::|.|||::...|||.:||::
Human   305 RSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVF----- 364

  Fly   434 HQPSPRKGDYLHKNY----KRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSF 494
                |::..|...|:    .|.|||||||||.:.|:......:.. .||::|:|.:|.:|.||||
Human   365 ----PKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEA-YGDISERKLLRERLRCKSF 424

  Fly   495 KWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQ 559
            .|:::.|..:|   :.|.|.|.: .||:::.|..:.|||            |...||..|
Human   425 DWYLKNVFPNL---HVPEDRPGW-HGAIRSRGISSECLD------------YNSPDNNPT----- 468

  Fly   560 FWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLEL 624
                                      .|.:.|:.||.|||||::.|. .:|:::..:....|.|:
Human   469 --------------------------GANLSLFGCHGQGGNQFFEYT-SNKEIRFNSVTELCAEV 506

  Fly   625 LPFSQEVVANKCDTD 639
            ......|....|..|
Human   507 PEQKNYVGMQNCPKD 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	138/304 (45%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	27/125 (22%)
GALNT4	NP_003765.2	Catalytic subdomain A	134..243		62/109 (57%)
		pp-GalNAc-T	138..432	CDD:133004	138/304 (45%)
		Catalytic subdomain B	303..365		34/70 (49%)
		beta-trefoil_Ricin_GALNT4	442..577	CDD:467347	27/125 (22%)