DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and Galnt5

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_113984.1	Gene:	Galnt5 / 83627	RGDID:	620361	Length:	930	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	228/678 - (33%)
Similarity:	330/678 - (48%)	Gaps:	126/678 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GVEPVPEKAGLSGDVKV-----KVPAIKQPEPQKPQEPDFEEDP-------------ELQKIDEP 89
            ||.|..:.|.::...|:     ::..|.:.|.||   .|.:|.|             |.|....|
  Rat   292 GVLPEADGAKVAPGKKLNFSESQIVIITKEEGQK---TDTKEVPNSKIQTVFPKLLGESQGKHIP 353

  Fly    90 EPVEEEVDNP-HPADDEPQQQP--QEELQMA---------------APADASVKKDWH-----DY 131
            ....:.:.:| .|.....|.:|  .|||..|               :.|:.|.....|     |.
  Rat   354 RSQSQTLSSPLAPKRAVSQSKPTLAEELHTARSNLTAKATTVGHQQSHANISENPGKHHVLRIDV 418

  Fly   132 TFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKE 196
            |...:|..  ..|:.|:...:....:::.|:|.. |..||..|||.|.|:|::.|.|...|.::.
  Rat   419 TLSPRDLN--APGQFGRPVVVPPGKKKEAEQRWK-EGNFNVYLSDLIPVDRAIEDTRPAGCAEQL 480

  Fly   197 YVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHF 261
            ....|||.|:|:.|.:|..|.|:|||||::|||||.|:|||:||||.|.::||...|:.|::: |
  Rat   481 VHNDLPTTSIIMCFVDEVWSALLRSVHSVLNRSPPHLIKEILLVDDFSTKDYLKANLDKYMSQ-F 544

  Fly   262 KWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDV 326
            ..||::||..|.|||.||.|||:|||.:||.|||||||.|..||.||||.:.||::...||.|:|
  Rat   545 PKVRILRLKERHGLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLNRKKVACPVIEV 609

  Fly   327 IDHTNFHYRAQDEGARGAFDW--EFFYKRLP---LLPEDLKHPADPFKSPIMAGGLFAISREFFW 386
            |:..:..|...|...||.|.|  .|.::.:|   :....:|. .|..:.|:||||||:|.:.:|:
  Rat   610 INDKDMSYMTVDNFQRGVFTWPMNFGWRTIPPDVIAKNGIKE-TDIIRCPVMAGGLFSIDKSYFY 673

  Fly   387 ELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRV 451
            |||.||.|||:||||..|||||:||||||:...||||:|||:|....:.....:...:.:|..||
  Rat   674 ELGTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRV 738

  Fly   452 AEVWMDEYKNYLYSHGDGLY-ESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPP 515
            ||||:||||...|.|||.|. :.:|.|:||:|:.:|.||.|:||||:::.|..||..      |.
  Rat   739 AEVWLDEYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCQSFKWYLDNVFPDLKA------PV 797

  Fly   516 SYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDV 580
            ..|.|...|:        .||:                                       |:.:
  Rat   798 VRASGVFINL--------ALGK---------------------------------------CVSI 815

  Fly   581 QIWDANAPVWLWDCHSQGGNQYWYYDYRHKQL-KHGTEGRRCLELLPFSQEVVANKCDTDNRFQQ 644
            :    |..|.|.||  .|.::...::|...:| ||   |..|:..:|....:....||..|...:
  Rat   816 K----NITVVLEDC--DGSSELQQFNYTWVRLIKH---GEWCVAPIPDKGSLTLYPCDNRNNRLK 871

  Fly   645 W---NFGSFNKTALD-----NYSQDLVL 664
            |   :..:|:...:|     :|.|.|.:
  Rat   872 WLHRSASAFHPELVDHIVFESYQQLLCM 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	110/218 (50%)
		pp-GalNAc-T	205..502	CDD:133004	148/302 (49%)
		RICIN	520..647	CDD:238092	22/130 (17%)
		Ricin_B_lectin	520..645	CDD:279046	21/125 (17%)
Galnt5	NP_113984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..210
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377		7/32 (22%)
		WcaA	484..>599	CDD:223539	66/115 (57%)
		Catalytic subdomain A	485..594		64/109 (59%)
		pp-GalNAc-T	489..790	CDD:133004	148/302 (49%)
		Catalytic subdomain B	654..716		39/61 (64%)
		RICIN	804..925	CDD:214672	26/152 (17%)
		RICIN	810..924	CDD:238092	24/138 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810