DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and GALNT11

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001358393.1	Gene:	GALNT11 / 63917	HGNCID:	19875	Length:	667	Species:	Homo sapiens

Alignment Length:	627	Identity:	222/627 - (35%)
Similarity:	315/627 - (50%)	Gaps:	109/627 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLISLTLFVLITSWIS----STPYTNKPVH----HGVEPVPEKAGLSGDVKVKVPAIKQPEPQKP 72
            |..|.|..||:..:.:    :.|..|.||.    ||  |.|:|.         .|...: .|.:.
Human    14 LFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHG--PSPKKF---------YPRFTR-GPSRV 66

  Fly    73 QEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTFMEKD 137
            .||.|:.:    |||  :.::..|::|    :|...:...||.|               .|.|:
Human    67 LEPQFKAN----KID--DVIDSRVEDP----EEGHLKFSSELGM---------------IFNER- 105

  Fly   138 AKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLP 202
                            |:..|||..:   ::.||.|:||.:..:|.|||.|:..|::|.|...||
Human   106 ----------------DQELRDLGYQ---KHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLP 151

  Fly   203 TVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKW-VRV 266
            ..||:|.||||..|.|:|:|||:|:|:|..|:.|||||||.||.:.|..||:.|:.::... ::|
Human   152 AASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKV 216

  Fly   267 VRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTN 331
            :|..:|.|||..|..||.:||.|||:|||||.|.|..||.|||..|..::.|.|||.||:|....
Human   217 IRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADT 281

  Fly   332 FHYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPAD----PFKSPIMAGGLFAISREFFWELGGYD 392
            ..| :.....||.|:|...:| ..|:|......|:    |.|||.|||||||::|::|.|||.||
Human   282 LAY-SSSPVVRGGFNWGLHFK-WDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYD 344

  Fly   393 EGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMD 457
            .|:||||||..|:||:||||||:::..||||:|||:| .|....||...|.:..|..|:|.||:|
Human   345 SGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFR-KRRPYGSPEGQDTMTHNSLRLAHVWLD 408

  Fly   458 EYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYP------------ 510
            |||...:|....| ::...|:::|:..:|.||.||||||:::.|       ||
Human   409 EYKEQYFSLRPDL-KTKSYGNISERVELRKKLGCKSFKWYLDNV-------YPEMQISGSHAKPQ 465

  Fly   511 --------PVDPPSYAMGALQNVGNQNLCLDTLGR--KKHNKMGMYACADNIKTPQRTQFWELSW 565
                    |..|.....|.|.:: ..|.||...||  :|...:.:.||  :...|  .|.|..:.
Human   466 QPIFVNRGPKRPKVLQRGRLYHL-QTNKCLVAQGRPSQKGGLVVLKAC--DYSDP--NQIWIYNE 525

  Fly   566 KRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDY 607
            :.:|.| ....|||:....::.|..|..||..||:|.|.:.|
Human   526 EHELVL-NSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGY 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	106/218 (49%)
		pp-GalNAc-T	205..502	CDD:133004	141/301 (47%)
		RICIN	520..647	CDD:238092	27/90 (30%)
		Ricin_B_lectin	520..645	CDD:279046	27/90 (30%)
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		58/110 (53%)
		pp-GalNAc-T	154..452	CDD:133004	142/308 (46%)
		Catalytic subdomain B	319..381		41/61 (67%)
		Ricin_B_lectin	483..>564	CDD:366226	26/86 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740