DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant6 and GALNT16

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001161840.1	Gene:	GALNT16 / 57452	HGNCID:	23233	Length:	558	Species:	Homo sapiens

Alignment Length:	494	Identity:	190/494 - (38%)
Similarity:	271/494 - (54%)	Gaps:	44/494 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPP 231
            ::.||.|.||.:|.:|.:.|.||..|....|.:.||..||||.|:||..|.|:|:|.|::||:|.
Human    88 QHAFNQLESDKLSPDRPIRDTRHYSCPSVSYSSDLPATSVIITFHNEARSTLLRTVKSVLNRTPA 152

  Fly   232 ELMKEIILVDD-HSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLD 295
            .|::||||||| .||.|      :..:......|:.:|..||.|||.:|..||..|.|.||.|||
Human   153 NLIQEIILVDDFSSDPE------DCLLLTRIPKVKCLRNDRREGLIRSRVRGADVAAATVLTFLD 211

  Fly   296 SHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDWEFFYK--RLPLLP 358
            ||.|.|..||||:|:.:..:....|.|.||||...||.|.|.....||.|||...:|  ::||..
Human   212 SHCEVNTEWLPPMLQRVKEDHTRVVSPIIDVISLDNFAYLAASADLRGGFDWSLHFKWEQIPLEQ 276

  Fly   359 EDLK-HPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCS 422
            :..: .|..|.::|::|||:|.|.:.:|..||.||..:||||||.:||||::|||||.:...|||
Human   277 KMTRTDPTRPIRTPVIAGGIFVIDKSWFNHLGKYDAQMDIWGGENFELSFRVWMCGGSLEIVPCS 341

  Fly   423 RIGHIYRGPRNHQPSPRKGDYLH--KNYKRVAEVWMDEYKNYLY-SHGDGLYESVDPGDLTEQKA 484
            |:||::|  :.|..:..:|:.|.  :|.||.|||||||||.|.| :....:.::.  |.:..:..
Human   342 RVGHVFR--KRHPYNFPEGNALTYIRNTKRTAEVWMDEYKQYYYEARPSAIGKAF--GSVATRIE 402

  Fly   485 IRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNL-CLDTLGRKKHNK--MGMY 546
            .|.|:|||||:|::|.|       ||.:..|  ...||..:..|.: ||::.|:.....  :||.
Human   403 QRKKMNCKSFRWYLENV-------YPELTVP--VKEALPGIIKQGVNCLESQGQNTAGDFLLGMG 458

  Fly   547 ACADNIKTPQRTQFWELSWKRDLRLRRKKECL---DVQIWDANAPVWLWDCHSQGGNQYWYYDYR 608
            .|..:.|.||..|.|..|   |..::::.:||   ...:....:||.|..|:.:.|.|.|    |
Human   459 ICRGSAKNPQPAQAWLFS---DHLIQQQGKCLAATSTLMSSPGSPVILQMCNPREGKQKW----R 516

  Fly   609 HKQ--LKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQW 645
            .|.  ::|...| .|||..|  .::|.:||..|.:.|||
Human   517 RKGSFIQHSVSG-LCLETKP--AQLVTSKCQADAQAQQW 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	97/217 (45%)
		pp-GalNAc-T	205..502	CDD:133004	132/303 (44%)
		RICIN	520..647	CDD:238092	40/134 (30%)
		Ricin_B_lectin	520..645	CDD:279046	38/132 (29%)
GALNT16	NP_001161840.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..54
		Catalytic subdomain A	122..227		54/110 (49%)
		pp-GalNAc-T	126..420	CDD:133004	133/310 (43%)
		Catalytic subdomain B	286..348		33/61 (54%)
		Ricin_B_lectin	441..543	CDD:395527	31/111 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740