Protein Alignment Pgant6 and GALNT18

DIOPT Version :9

• Sequence 1: NP_001261342.1
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_940918.2
• Gene: GALNT18 / 374378
• HGNCID: 30488
• Length: 607
• Species: Homo sapiens
• Alignment Length: 666
• Identity: 204/666 - (30%)
• Similarity: 318/666 - (47%)
• Gaps: 111/666 - (16%)

  Fly    12 ASLLLLISLT--LFVLITSWISSTPYTNKPVHHGVEPVPEKAGLSGDVKVKVPAIKQPEPQKPQE 74
            ::.::|..:|  :.:|...|:  |.|.......|.||.|:|
Human    12 STCVILSGMTNIICLLYVGWV--TNYIASVYVRGQEPAPDK------------------------ 50

  Fly    75 PDFEEDPE-----LQKIDEPEPV-----EEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWH 129
             ..|||..     ::::|..|.|     :|....|..|:.||.            .|:|:...|
Human    51 -KLEEDKGDTLKIIERLDHLENVIKQHIQEAPAKPEEAEAEPF------------TDSSLFAHW- 101

  Fly   130 DYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRK 194
                               ...|..|.:|...|:... .|:||.|||.:.::|.:||:|...||.
Human   102 -------------------GQELSPEGRRVALKQFQY-YGYNAYLSDRLPLDRPLPDLRPSGCRN 146

  Fly   195 KEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYI-- 257
            ..:...||.||::.||.||.||||:||:||.:.|:||.|:||||||||:|..|.|.::|..|:
Human   147 LSFPDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPPHLLKEIILVDDNSSNEELKEKLTEYVDK 211

  Fly   258 --AEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAV 320
              ::...:::|||..::.|||.:|.:|.|.|||.|:...|:|||.|..|..|:|..|..|::..:
Human   212 VNSQKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRII 276

  Fly   321 CPFIDVIDHTNFHYRAQDEGARGAFDWEFF--YKRLPLLPEDLKHPADPFKSPIMAGGLFAISRE 383
            .|..|.|.:.||........|:| ||||.:  |...|.....|::...|.:||.:. |.|.:.|:
Human   277 SPSFDNIKYDNFEIEEYPLAAQG-FDWELWCRYLNPPKAWWKLENSTAPIRSPALI-GCFIVDRQ 339

  Fly   384 FFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQP-SPRKGDYLHKN 447
            :|.|:|..|||::::|||..||..::|.|||.:...|||||.||.|.   |:| :.....::.:|
Human   340 YFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERA---HKPYTEDLTAHVRRN 401

  Fly   448 YKRVAEVWMDEYKNYLYSHGDGLYE--SVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYP 510
            ..|||||||||:|:::|...:...|  .:|.||:|.:||:|.:|.||:|:|::..| :..|:.|.
Human   402 ALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSV-YPEMRMYS 465

  Fly   511 PVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKK 575
            .:    .|.|.|||....:||||. |....|...||.|  :..|||...:   :..:.:.:....
Human   466 DI----IAYGVLQNSLKTDLCLDQ-GPDTENVPIMYIC--HGMTPQNVYY---TSSQQIHVGILS 520

  Fly   576 ECLDVQ----IWDANAPVWLWDC-HSQGGNQYWYYDYRHKQLKHGTEGRRCLEL-----LPFSQE 630
            ..:|..    :.|.|:...|.:| :::......::.:.........:.:|||||     |.|..:
Human   521 PTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGPIQNRKSKRCLELQENSDLEFGFQ 585

  Fly   631 VVANKCDTDNRFQQWN 646
            :|..||..    |.|:
Human   586 LVLQKCSG----QHWS 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	88/219 (40%)
		pp-GalNAc-T	205..502	CDD:133004	123/305 (40%)
		RICIN	520..647	CDD:238092	33/137 (24%)
		Ricin_B_lectin	520..645	CDD:279046	32/134 (24%)
GALNT18	NP_940918.2	Catalytic subdomain A	153..267		54/113 (48%)
		pp-GalNAc-T	157..458	CDD:133004	124/306 (41%)
		Catalytic subdomain B	324..385		28/61 (46%)
		RICIN	471..598	CDD:238092	33/137 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810