DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and Galntl6

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001129228.1	Gene:	Galntl6 / 361142	RGDID:	1564773	Length:	601	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	269/552 - (48%)
Similarity:	349/552 - (63%)	Gaps:	30/552 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 DASVKKDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVP 185
            |...:||||||..::|||.|.|.||.||...|.:|...|...|   |||||..:|::|::.||:|
  Rat    62 DGLRRKDWHDYVSIQKDALRSGKGEHGKPYPLTEEDHDDSAYR---ENGFNIFVSNNIALERSLP 123

  Fly   186 DIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLG 250
            ||||..|:.|.|:.:||..|:||.|:||..:.|:|::||:|||:|..|:.|||||||.||||:|.
  Rat   124 DIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPESLIAEIILVDDFSDREHLK 188

  Fly   251 KELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALN 315
            .:||.|:| .|..||:||..:|.|||..|..||..|..|||.|||||.|.|.|||||||..||||
  Rat   189 DKLEDYMA-RFPIVRIVRTKKREGLIRTRLLGASVARGEVLTFLDSHCEVNVNWLPPLLNQIALN 252

  Fly   316 KRTAVCPFIDVIDHTNFHYRAQ-DEGARGAFDWEFFYKRLPLLPE-DLKHPADPFKSPIMAGGLF 378
            .:|.|||.||||||::|.|.|| .:..|||||||.:|||:|:.|| ....|::||:||:||||||
  Rat   253 HKTIVCPMIDVIDHSHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSEPFESPVMAGGLF 317

  Fly   379 AISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQ-PSPRKGD 442
            |:.|::||||||||.||:||||||||:|||:|||||||:|.||||:|||||....:: ||   |.
  Rat   318 AVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPS---GT 379

  Fly   443 YLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMK 507
            .|.:|.|||||.||||:..|:|..... |..:..||::.||.:|.:|.||.|||||..||:|:.|
  Rat   380 SLARNLKRVAETWMDEFAEYIYQRRPE-YRHLSTGDISAQKELRKRLKCKDFKWFMAAVAWDVPK 443

  Fly   508 TYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACAD------NIKTPQRTQFWELSWK 566
            .||||:|...|.|.::||. .|||:|:    ||..||.....|      :.:|....|.:...|:
  Rat   444 YYPPVEPLPAAWGEIRNVA-ANLCVDS----KHGAMGTELRLDICVKDGSERTWSHEQLFTFGWR 503

  Fly   567 RDLR----LRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLELLPF 627
            .|:|    |..:|.|||.  ...::||.|:|||...|||.|  .||..:.........|::..|.
  Rat   504 EDIRPGEPLHTRKFCLDA--ISHSSPVTLYDCHGMKGNQLW--GYREDRTLFHPVSNSCMDCNPA 564

  Fly   628 SQEVVANKCDTDNRFQQWNFGSFNKTALDNYS 659
            .::|...:||..:..|||.|...|.|.|:..|
  Rat   565 EKKVFMARCDPLSETQQWMFEHINMTVLEKIS 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	130/215 (60%)
		pp-GalNAc-T	205..502	CDD:133004	173/299 (58%)
		RICIN	520..647	CDD:238092	42/136 (31%)
		Ricin_B_lectin	520..645	CDD:279046	40/134 (30%)
Galntl6	NP_001129228.1	Glyco_tranf_2_3	140..365	CDD:290369	139/225 (62%)
		pp-GalNAc-T	143..438	CDD:133004	173/299 (58%)
		Ricin_B_lectin	454..582	CDD:279046	41/136 (30%)
		RICIN	456..584	CDD:238092	42/136 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2484
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1247
OMA	1	1.010	-	-		QHG48703
OrthoDB	1	1.010	-	-		D144590at33208
OrthoFinder	1	1.000	-	-		FOG0001284
OrthoInspector	1	1.000	-	-		mtm9134
orthoMCL	1	0.900	-	-		OOG6_104854
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1309
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980