Protein Alignment Pgant6 and Galnt7

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_075215.1
• Gene: Galnt7 / 29750
• RGDID: 620362
• Length: 657
• Species: Rattus norvegicus
• Alignment Length: 681
• Identity: 229/681 - (33%)
• Similarity: 334/681 - (49%)
• Gaps: 127/681 - (18%)

  Fly    13 SLLLLISLTLFVLITSWISSTPYTNKPVHHGVE------PVPEKAG---LSGDVKVKVPAIKQPE 68
            |||::.|....|::.|.:||.|....|:....|      |:|.:.|   ..||.:.| |.:..|.
  Rat    11 SLLVVGSFLGLVVLWSSLSSRPDDPSPLSRMREDRDVNNPLPNRGGNGLAPGDDRFK-PVVPWPH 74

  Fly    69 PQKPQEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTF 133
            .:       ..:.:|:.|......:.|.:. |...|..:...|.:.....|           .||
  Rat    75 VE-------GVEVDLESIRRKNKAKNEQER-HAGGDSQKDIMQRQYLTFKP-----------QTF 120

  Fly   134 MEKD-AKRVGL------------------GEGGKASTLDDESQRDLEKRMSLENGFNALLSDSIS 179
            ..:| ..|.|:                  ||..|...|..|.::..:..:. |.|||...||.||
  Rat   121 TYRDPVLRPGVLGNFEPKEPEPHGVVGGPGENAKPLVLGPEYKQAAQASIK-EFGFNMAASDMIS 184

  Fly   180 VNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHS 244
            ::|||.|:|...|:...|...|.|.||:|:|:||..|.|||:|||:|.|:|.:.:.||:|:||.|
  Rat   185 LDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFS 249

  Fly   245 DREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNA-TAEVLIFLDSHVEANYNWLPPL 308
            ::|:|.::|..||......|:|.|..||.|||.||:.||:.| ..:|||:||:|.|...||..||
  Rat   250 NKEHLKEKLTEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPL 314

  Fly   309 LEPIALNKRTAVCPFIDVIDHTNFHYRAQDEG-----ARGAFDWEFFYKRLPLLPED---LKHPA 365
            :.||:.::.....|.||||:...:....|..|     ||||:||...:||:||.|.:   .|...
  Rat   315 VAPISKDRTICTVPIIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPREKRLRKTKT 379

  Fly   366 DPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYR- 429
            :|::||.||||||||.|:||:|||.||.||.|||||.:|:|:|||.|||::...||||:|||||
  Rat   380 EPYRSPAMAGGLFAIERDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRL 444

  Fly   430 -GPRNHQP------SPRKGDYLHKNYKRVAEVWMDEYKNYLY-SHGDGLYESVDPGDLTEQKAIR 486
             |.:.:.|      ||..     |||.||.|||.||||:|.| |..:.  :::..||::|.|..|
  Rat   445 EGWQGNPPPLYVGSSPTL-----KNYVRVVEVWWDEYKDYFYASRPES--KALPYGDISELKKFR 502

  Fly   487 TKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADN 551
            ...|||||||||||:|:|:...| |:.|.:...|.::.: ....|:|::|:....
  Rat   503 EDHNCKSFKWFMEEIAYDITAHY-PLPPRNVEWGEIRGL-ETAYCIDSMGKTNGG---------- 555

  Fly   552 IKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGT 616
                    |.||.                            .||..||||.:..:..::.:::.
  Rat   556 --------FVELG----------------------------PCHRMGGNQLFRINEANQLMQYD- 583

  Fly   617 EGRRCLELLPFSQEVVANKCDTDNRFQQWNF 647
               :||...|...:|:...|:. |.|::|.:
  Rat   584 ---QCLTKGPDGSKVMITHCNL-NEFKEWQY 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	150/314 (48%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	21/133 (16%)
Galnt7	NP_075215.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..66		9/35 (26%)
		Catalytic subdomain A	206..317		53/110 (48%)
		pp-GalNAc-T	210..518	CDD:133004	150/314 (48%)
		Catalytic subdomain B	381..443		41/61 (67%)
		beta-trefoil_Ricin_GALNT7	530..653	CDD:467315	21/133 (16%)