DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and Galntl6

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_017168336.2	Gene:	Galntl6 / 270049	MGIID:	1913581	Length:	695	Species:	Mus musculus

Alignment Length:	579	Identity:	270/579 - (46%)
Similarity:	356/579 - (61%)	Gaps:	34/579 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 VDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDL 160
            |.:..||:.:.......:.|..:..|...:||||||..:::||.|.|.||.||...|.:|.:.|.
Mouse   131 VKSAEPAEHQTFPLGLGDGQFYSWTDGLRRKDWHDYESIQRDALRSGKGEHGKPYPLTEEDRDDS 195

  Fly   161 EKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSL 225
            ..|   |||||..:|::|::.||:|||||..|:.|.|:.:||..|:||.|:||..:.|:|::||:
Mouse   196 AYR---ENGFNIFVSNNIALERSLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSI 257

  Fly   226 INRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEV 290
            |||:|..|:.|||||||.||||:|..:||.|:| .|..||:||..:|.|||..|..||..|..||
Mouse   258 INRTPESLIAEIILVDDFSDREHLKDKLEDYMA-RFSKVRIVRTKKREGLIRTRLLGASVARGEV 321

  Fly   291 LIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQ-DEGARGAFDWEFFYKRL 354
            |.|||||.|.|.|||||||..||||.:|.|||.||||||.:|.|.|| .:..|||||||.:|||:
Mouse   322 LTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRI 386

  Fly   355 PLLPE-DLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYD 418
            |:.|| ....|:|||:||:|||||||:.|::||||||||.||:||||||||:|||:|||||||:|
Mouse   387 PIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFD 451

  Fly   419 APCSRIGHIYRGPRNHQPSPRK---GDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDLT 480
            .||||:|||||     :..|.|   |..|.:|.|||||.||||:..|:|..... |..:..||::
Mouse   452 VPCSRVGHIYR-----KYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPE-YRHLSTGDIS 510

  Fly   481 EQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGM 545
            .||.:|.:|.||.|||||..||:|:.|.||||:|...|.|.:::|. .|||:|:    ||...|.
Mouse   511 AQKELRKRLKCKDFKWFMAAVAWDVPKYYPPVEPLPAAWGEIRSVA-ANLCVDS----KHGATGT 570

  Fly   546 YACAD------NIKTPQRTQFWELSWKRDLR----LRRKKECLDVQIWDANAPVWLWDCHSQGGN 600
            ....|      :.:|....|.:...|:.|:|    |..:|.|||.  ...::||.|:|||...||
Mouse   571 ELRLDVCVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCLDA--ISHSSPVTLYDCHGMKGN 633

  Fly   601 QYWYYDYRHKQLKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQWNFGSFNKTALDNYS 659
            |.|  .||..:.........|::..|..:::...:||..:..|||.|...|.|.|:..|
Mouse   634 QLW--GYREDRTLFHPVSNSCMDCNPSEKKIFMARCDPLSETQQWIFEHINMTVLEKNS 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	131/215 (61%)
		pp-GalNAc-T	205..502	CDD:133004	174/301 (58%)
		RICIN	520..647	CDD:238092	39/136 (29%)
		Ricin_B_lectin	520..645	CDD:279046	37/134 (28%)
Galntl6	XP_017168336.2	pp-GalNAc-T	237..532	CDD:133004	174/301 (58%)
Galntl6	XP_017168336.2	Ricin_B_lectin	548..676	CDD:366226	38/136 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842565
Domainoid	1	1.000	223	1.000	Domainoid score	I2564
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1279
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48703
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001284
OrthoInspector	1	1.000	-	-		mtm8888
orthoMCL	1	0.900	-	-		OOG6_104854
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1309
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900