DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and GALNT8

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_059113.1	Gene:	GALNT8 / 26290	HGNCID:	4130	Length:	637	Species:	Homo sapiens

Alignment Length:	589	Identity:	185/589 - (31%)
Similarity:	295/589 - (50%)	Gaps:	89/589 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTFMEKDAKRVGLGEGGKAST 151
            ||..|:.:.::.      :..:..:.:.||.....:.:.:.|                 |...|.
Human    93 DEVRPLLKAMET------KVNETKKHKTQMKLFPHSQLFRQW-----------------GEDLSE 134

  Fly   152 LDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLS 216
            ...::.:||.::.    |:||.||:.:.:||::||.|...|.:|.|.::||::|||:||.||.||
Human   135 AQQKAAQDLFRKF----GYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLPSLSVILIFVNEALS 195

  Fly   217 VLMRSVHSLINRSPPELMKEIILVDDHSD----REYLGKELETYIAEHFKWVRVVRLPRRTGLIG 277
            ::.|::.|:|||:|..|:||||||||.|.    :.:|.::::.|..::...::::|.|.|.||..
Human   196 IIQRAITSIINRTPSRLLKEIILVDDFSSNGELKVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQ 260

  Fly   278 ARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGAR 342
            ||..|...|||:|:..||:|:|.|..|..|:|..|..::...|.|..|.|....|.....:....
Human   261 ARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVD 325

  Fly   343 GAFDWEFF--YKRLPLLPEDLKHPADPFKSP-IMAGGLFAISREFFWELGGYDEGLDIWGGEQYE 404
            | |:||.:  |..||....||.....|.||| ||  |:.|.:|.|..|:|..|.|:.|:|||..|
Human   326 G-FNWELWCRYDALPQAWIDLHDVTAPVKSPSIM--GILAANRHFLGEIGSLDGGMLIYGGENVE 387

  Fly   405 LSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDY-------LHKNYKRVAEVWMDEYKNY 462
            ||.::|.|||::...|||||.|:   .|:|:|      |       |.:|..||||:||||:|:.
Human   388 LSLRVWQCGGKVEILPCSRIAHL---ERHHKP------YALDLTAALKRNALRVAEIWMDEHKHM 443

  Fly   463 LY-SHGDGLYES-VDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDP--PSYAMGALQ 523
            :| :....|..| :|.||::.:.|:|.||.||:|.|:::.|       ||.:.|  .....|.::
Human   444 VYLAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNV-------YPLLKPLHTIVGYGRMK 501

  Fly   524 NVGNQNLCLDTLGRKKHNKMGMYAC----ADNIKTPQRTQFWELSWKRDL-RLRRKKECLDVQIW 583
            |:.::|:|||. |....|...||.|    :.|:       ::.|:.:..: :|..:....|..:.
Human   502 NLLDENVCLDQ-GPVPGNTPIMYYCHEFSSQNV-------YYHLTGELYVGQLIAEASASDRCLT 558

  Fly   584 D---ANAPVWLWDCHSQGGNQ-YWYYDYRHKQLKHGTEGRRCLEL---LPFSQEVVANKCDTDNR 641
            |   |..|. |..|.....|: :.|:|::........:.:||||:   |..|..:|...|.|
Human   559 DPGKAEKPT-LEPCSKAAKNRLHIYWDFKPGGAVINRDTKRCLEMKKDLLGSHVLVLQTCST--- 619

  Fly   642 FQQW 645
             |.|
Human   620 -QVW 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	86/220 (39%)
		pp-GalNAc-T	205..502	CDD:133004	122/312 (39%)
		RICIN	520..647	CDD:238092	34/138 (25%)
		Ricin_B_lectin	520..645	CDD:279046	33/136 (24%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		10/81 (12%)
		SMC_N	<48..>161	CDD:330553	15/94 (16%)
		GT1 motif	182..298		48/115 (42%)
		pp-GalNAc-T	184..485	CDD:133004	123/319 (39%)
		Gal/GalNAc transferase motif	358..397		18/40 (45%)
		RICIN	498..624	CDD:238092	34/138 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810