DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant6 and Pgant4

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster

Alignment Length:	666	Identity:	316/666 - (47%)
Similarity:	421/666 - (63%)	Gaps:	50/666 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLLLISLTLFVLITSWISSTPYTNKPVHHGVEPVPEKAGLSGDVKVKV-------PAIKQPEP-- 69
            ||..:.|.|.|::|..:.:|....:.:.:..| :.|:...:||....|       |..|.|.|
  Fly    11 LLRKVVLLLVVIVTVSLVTTLVVERRMKNAAE-LTEQLDPNGDPITPVFRAANIHPTRKAPRPPF 74

  Fly    70 -QKPQEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTF 133
             .:....|.....:||....|||..|                              :||||||..
  Fly    75 QDRNSVVDIPRSDKLQGFRLPEPKGE------------------------------RKDWHDYAA 109

  Fly   134 MEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYV 198
            ||.|.||.|.||.|.|..:::..::.|||.....||||.|:||.|||||||||:|...|:.::|:
  Fly   110 MEADRKRSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYL 174

  Fly   199 AKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHF-K 262
            ||||.:|||.||:||:.:.|:||::|:|||:||||:|:|:||||.|:.:.|.:.|:.|:.:|| .
  Fly   175 AKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPH 239

  Fly   263 WVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVI 327
            .|.:||.|.|.||||||.|||:.|..:|::|.|||:|.||||||||:||||:|.:.:.||.:|.|
  Fly   240 LVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTI 304

  Fly   328 DHTNFHY-RAQDEGARGAFDWEFFYKRLPLLPEDLKHPADPFKSPIMAGGLFAISREFFWELGGY 391
            .|.:|.| ....:||||.|||:..||:||:||||....:.|::||:|.||||||:.:|||:||||
  Fly   305 SHEDFSYFSGNKDGARGGFDWKMLYKQLPVLPEDALDKSMPYRSPVMMGGLFAINTDFFWDLGGY 369

  Fly   392 DEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWM 456
            |:.||||||||||||||||||||.:.|.||||:.||:|||...:.:||..:::.||:||||||||
  Fly   370 DDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWM 434

  Fly   457 DEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGA 521
            ||||.|:|......|:::|.||||.|:.:|.:|.||||.|||.|||.|.:..:|||:|||||.|.
  Fly   435 DEYKQYVYKRDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGI 499

  Fly   522 LQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRR-KKECLDVQIWDA 585
            :|||.|...|||.:|:.....:||::||||...||..||||||..||||::. ...||||.....
  Fly   500 IQNVANPVYCLDNMGKSTEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGFDSVCLDVHEGPP 564

  Fly   586 NAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLELLPFSQ----EVVANKCDTDNRFQQWN 646
            ||.||:|.||||||||:||||.:.::|.||...:||||  .|.:    :||||.|:..|..|:|.
  Fly   565 NATVWMWSCHSQGGNQFWYYDRQTQRLVHGENNKRCLE--GFVENGIAKVVANSCENGNDRQRWE 627

  Fly   647 FGSFNKTALDNYSQDL 662
            ||..|.|.||.:...|
  Fly   628 FGFVNHTMLDTFYDGL 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	125/215 (58%)
		pp-GalNAc-T	205..502	CDD:133004	169/298 (57%)
		RICIN	520..647	CDD:238092	64/131 (49%)
		Ricin_B_lectin	520..645	CDD:279046	63/129 (49%)
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	134/233 (58%)
		pp-GalNAc-T	181..480	CDD:133004	169/298 (57%)
		Ricin_B_lectin	496..626	CDD:279046	64/131 (49%)
		RICIN	498..628	CDD:238092	64/131 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468120
Domainoid	1	1.000	211	1.000	Domainoid score	I2739
eggNOG	1	0.900	-	-		E1_KOG3736
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1301
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144590at33208
OrthoFinder	1	1.000	-	-		FOG0001284
OrthoInspector	1	1.000	-	-		mtm6424
orthoMCL	1	0.900	-	-		OOG6_104854
Panther	1	1.100	-	-	P	PTHR11675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2546
SonicParanoid	1	1.000	-	-		X1309
	12	11.830