DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and Galnt5

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_766443.2	Gene:	Galnt5 / 241391	MGIID:	2179403	Length:	930	Species:	Mus musculus

Alignment Length:	657	Identity:	224/657 - (34%)
Similarity:	326/657 - (49%)	Gaps:	114/657 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VPEKAGLSGDVKVKVPAIK-----------QPEPQKPQEPDFEEDPELQKIDEPEPVEEEVDNPH 100
            :.::..|..|.| :||..|           .|..|.|:.       :.:....|..:::.|....
Mouse   318 ITKEEELKTDTK-EVPNSKTQTVFPKLLGGSPHKQIPRN-------QSKTSSSPPALKKAVSQSK 374

  Fly   101 PADDEPQQQPQEELQMAAP------ADASVKKD--WH-----DYTFMEKDAKRVGLGEGGKASTL 152
            |.........:..|...||      :.|::.::  .|     |.|...:|..  ..|:.|:...:
Mouse   375 PTISGGLHTARSNLTAKAPTVGYQQSHANIPENPGMHHVFRIDVTLSPRDLN--APGQFGRPVVV 437

  Fly   153 DDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSV 217
            ..|.:::.|:|.. |..||..|||.|.|:|::.|.|...|.::.....|||.|:|:.|.:|..|.
Mouse   438 PPEKKKEAEQRWK-EGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNDLPTTSIIMCFVDEVWSA 501

  Fly   218 LMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAG 282
            |:|||||::|||||.|:|||:||||.|.:|||..:|:.|::: |..||::||..|.|||.||.||
Mouse   502 LLRSVHSVLNRSPPHLIKEILLVDDFSTKEYLKADLDKYMSQ-FPKVRILRLKERHGLIRARLAG 565

  Fly   283 ARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDW 347
            |:|||.:||.|||||||.|..||.||||.:.||::...||.|:||:..:..|...|...||.|.|
Mouse   566 AQNATGDVLTFLDSHVECNVGWLEPLLERVYLNRKKVACPVIEVINDKDMSYMTVDNFQRGVFTW 630

  Fly   348 --EFFYKRLP---LLPEDLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSF 407
              .|.:|.:|   :....:|. .|..:.|:||||||:|.:.:|:|||.||.|||:||||..||||
Mouse   631 PMNFGWKTIPPDVVAKNGIKE-TDIIRCPVMAGGLFSIDKSYFYELGTYDPGLDVWGGENMELSF 694

  Fly   408 KIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLY- 471
            |:||||||:...||||:|||:|....:.....:...:.:|..||||||:|:|:...|.|||.|.
Mouse   695 KVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDDYRELFYGHGDHLID 759

  Fly   472 ESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLG 536
            :.:|.|:||:|:.:|.||.||||||:::.|..||..      |...|.|.|.|:        .||
Mouse   760 QGLDVGNLTQQRELRKKLKCKSFKWYLDNVFPDLKA------PVVRASGVLINM--------ALG 810

  Fly   537 RKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQ 601
            :                                       |:.::    |..|.|.||  .|.:|
Mouse   811 K---------------------------------------CVSIE----NITVTLEDC--DGSSQ 830

  Fly   602 YWYYDYRHKQL-KHGTEGRRCLELLPFSQEVVANKCDTDNRFQQW---NFGSFNKTALD-----N 657
            ...::|...:| ||   |..|:..:|....:....||..|...:|   :..:|:...:|     |
Mouse   831 LQQFNYTWVRLIKH---GEWCVAPIPEKGSLTLYHCDNRNNRLKWLHKSASAFHPELVDHIVFEN 892

  Fly   658 YSQDLVL 664
            |.|.|.:
Mouse   893 YQQLLCM 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	112/218 (51%)
		pp-GalNAc-T	205..502	CDD:133004	149/302 (49%)
		RICIN	520..647	CDD:238092	24/130 (18%)
		Ricin_B_lectin	520..645	CDD:279046	23/125 (18%)
Galnt5	NP_766443.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..209
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..381		11/61 (18%)
		Catalytic subdomain A	485..594		65/109 (60%)
		pp-GalNAc-T	489..790	CDD:133004	149/302 (49%)
		Catalytic subdomain B	654..716		39/61 (64%)
		RICIN	805..925	CDD:214672	28/151 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810