Protein Alignment Pgant6 and Galnt18

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_776100.2
• Gene: Galnt18 / 233733
• MGIID: 2446239
• Length: 622
• Species: Mus musculus
• Alignment Length: 692
• Identity: 206/692 - (29%)
• Similarity: 315/692 - (45%)
• Gaps: 150/692 - (21%)

  Fly    12 ASLLLLISLT--LFVLITSWISSTPYTNKPVHHGVEPVPEKAGLSGDVKVKVPAIKQPEPQKPQE 74
            ::.::|..:|  :.:|...|:  |.|.......|.||||:|
Mouse    12 STCVILSGMTNIICLLYVGWV--TNYIASVYVRGQEPVPDK------------------------ 50

  Fly    75 PDFEEDPE-----LQKIDEPEPV-----EEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWH 129
             ..|||..     ::::|..|.|     :|....|..|:.||.            .|:|:...|
Mouse    51 -KLEEDKGDTLKIIERLDHLENVIKQHIQEAPAKPEEAEAEPF------------TDSSLFAHW- 101

  Fly   130 DYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRK 194
                               ...|..|.:|...|:... .|:||.|||.:.::|.:||:|...||.
Mouse   102 -------------------GQELSPEGRRVALKQFQY-YGYNAYLSDRLPLDRPLPDLRPSGCRN 146

  Fly   195 KEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYI-- 257
            ..:...||.||::.||.||.||||:||:||.:.|:|..|:||||||||:|..|.|.::|..|:
Mouse   147 LSFPDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPSHLLKEIILVDDNSSNEELKEKLTEYVDK 211

  Fly   258 --AEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAV 320
              .:...:::|||..::.|||.:|.:|.|.|||.|:...|:|||.|..|..|:|..|..|::..:
Mouse   212 VNGQKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRII 276

  Fly   321 CPFIDVIDHTNFHYRAQDEGARGAFDWEFF--YKRLPLLPEDLKHPADPFKSPIMAGGLFAISRE 383
            .|..|.|.:.||........|:| ||||.:  |...|.....|::...|.:||.:. |.|.:.|:
Mouse   277 SPSFDNIKYDNFEIEEYPLAAQG-FDWELWCRYLNPPKAWWKLENSTAPIRSPALI-GCFIVDRQ 339

  Fly   384 FFWELGGYDEGLDIWGGEQYELSFK---------------IWMCGGEMYDAPCSRIGHIYRGPRN 433
            :|.|:|..|||::::|||..||..:               :|.|||.:...|||||.||.|.
Mouse   340 YFEEIGLLDEGMEVYGGENVELGIRVSEISHTGLSSAPMMVWQCGGSVEVLPCSRIAHIERA--- 401

  Fly   434 HQP-SPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYE--SVDPGDLTEQKAIRTKLNCKSFK 495
            |:| :.....::.:|..|||||||||:|:::|...:...|  .:|.||:|.:||:|.:|.||:|:
Mouse   402 HKPYTEDLTAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFR 466

  Fly   496 WFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQF 560
            |::..| :..|:.|..:    .|.|.|||....:||||. |....|...:|.|  :..|||...:
Mouse   467 WYLVSV-YPEMRMYSDI----IAYGVLQNSLKTDLCLDQ-GPDTENVPIVYIC--HGMTPQNVYY 523

  Fly   561 WELSWKRDLRLRRKKECLDVQ----IWDANAPVWLWDC-------------HSQGGNQYWYYDYR 608
               :..:.:.:......:|..    :.|.|:...|.:|             .||||:
Mouse   524 ---TSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGS-------- 577

  Fly   609 HKQLKHGTEGRRCLEL-----LPFSQEVVANKCDTDNRFQQW 645
                ....:.:|||||     :.|..::|..||..    |.|
Mouse   578 ----IQNRKSKRCLELQENSDMEFGFQLVLQKCSG----QHW 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	122/320 (38%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	36/153 (24%)
Galnt18	NP_776100.2	Catalytic subdomain A	153..267		53/113 (47%)
		pp-GalNAc-T	157..473	CDD:133004	123/321 (38%)
		Catalytic subdomain B	324..400		28/76 (37%)
		beta-trefoil_Ricin_GALNT18	476..617	CDD:467353	38/162 (23%)