DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and Galnt18

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_776100.2	Gene:	Galnt18 / 233733	MGIID:	2446239	Length:	622	Species:	Mus musculus

Alignment Length:	692	Identity:	206/692 - (29%)
Similarity:	315/692 - (45%)	Gaps:	150/692 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ASLLLLISLT--LFVLITSWISSTPYTNKPVHHGVEPVPEKAGLSGDVKVKVPAIKQPEPQKPQE 74
            ::.::|..:|  :.:|...|:  |.|.......|.||||:|
Mouse    12 STCVILSGMTNIICLLYVGWV--TNYIASVYVRGQEPVPDK------------------------ 50

  Fly    75 PDFEEDPE-----LQKIDEPEPV-----EEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWH 129
             ..|||..     ::::|..|.|     :|....|..|:.||.            .|:|:...|
Mouse    51 -KLEEDKGDTLKIIERLDHLENVIKQHIQEAPAKPEEAEAEPF------------TDSSLFAHW- 101

  Fly   130 DYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRK 194
                               ...|..|.:|...|:... .|:||.|||.:.::|.:||:|...||.
Mouse   102 -------------------GQELSPEGRRVALKQFQY-YGYNAYLSDRLPLDRPLPDLRPSGCRN 146

  Fly   195 KEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYI-- 257
            ..:...||.||::.||.||.||||:||:||.:.|:|..|:||||||||:|..|.|.::|..|:
Mouse   147 LSFPDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPSHLLKEIILVDDNSSNEELKEKLTEYVDK 211

  Fly   258 --AEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAV 320
              .:...:::|||..::.|||.:|.:|.|.|||.|:...|:|||.|..|..|:|..|..|::..:
Mouse   212 VNGQKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRII 276

  Fly   321 CPFIDVIDHTNFHYRAQDEGARGAFDWEFF--YKRLPLLPEDLKHPADPFKSPIMAGGLFAISRE 383
            .|..|.|.:.||........|:| ||||.:  |...|.....|::...|.:||.:. |.|.:.|:
Mouse   277 SPSFDNIKYDNFEIEEYPLAAQG-FDWELWCRYLNPPKAWWKLENSTAPIRSPALI-GCFIVDRQ 339

  Fly   384 FFWELGGYDEGLDIWGGEQYELSFK---------------IWMCGGEMYDAPCSRIGHIYRGPRN 433
            :|.|:|..|||::::|||..||..:               :|.|||.:...|||||.||.|.
Mouse   340 YFEEIGLLDEGMEVYGGENVELGIRVSEISHTGLSSAPMMVWQCGGSVEVLPCSRIAHIERA--- 401

  Fly   434 HQP-SPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYE--SVDPGDLTEQKAIRTKLNCKSFK 495
            |:| :.....::.:|..|||||||||:|:::|...:...|  .:|.||:|.:||:|.:|.||:|:
Mouse   402 HKPYTEDLTAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFR 466

  Fly   496 WFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQF 560
            |::..| :..|:.|..:    .|.|.|||....:||||. |....|...:|.|  :..|||...:
Mouse   467 WYLVSV-YPEMRMYSDI----IAYGVLQNSLKTDLCLDQ-GPDTENVPIVYIC--HGMTPQNVYY 523

  Fly   561 WELSWKRDLRLRRKKECLDVQ----IWDANAPVWLWDC-------------HSQGGNQYWYYDYR 608
               :..:.:.:......:|..    :.|.|:...|.:|             .||||:
Mouse   524 ---TSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGS-------- 577

  Fly   609 HKQLKHGTEGRRCLEL-----LPFSQEVVANKCDTDNRFQQW 645
                ....:.:|||||     :.|..::|..||..    |.|
Mouse   578 ----IQNRKSKRCLELQENSDMEFGFQLVLQKCSG----QHW 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	87/234 (37%)
		pp-GalNAc-T	205..502	CDD:133004	122/320 (38%)
		RICIN	520..647	CDD:238092	35/148 (24%)
		Ricin_B_lectin	520..645	CDD:279046	34/146 (23%)
Galnt18	NP_776100.2	Catalytic subdomain A	153..267		53/113 (47%)
		pp-GalNAc-T	157..473	CDD:133004	123/321 (38%)
		Catalytic subdomain B	324..400		28/76 (37%)
		Ricin_B_lectin	484..611	CDD:279046	35/148 (24%)
		RICIN	486..613	CDD:238092	35/148 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900