Protein Alignment Pgant6 and Galnt12

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_766281.1
• Gene: Galnt12 / 230145
• MGIID: 2444664
• Length: 576
• Species: Mus musculus
• Alignment Length: 619
• Identity: 208/619 - (33%)
• Similarity: 290/619 - (46%)
• Gaps: 150/619 - (24%)

  Fly    88 EPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTFMEKDAKRVGLGEGGKASTL 152
            :|.|..    .|.|...|| ..|:..|    ||||                    ||..|:|..|
Mouse    44 DPGPPR----TPLPGRHEP-VLPRPPL----PADA--------------------LGAHGEAVRL 79

  Fly   153 DDESQR-DLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEY-VAKLPTVSVIIIFYNEYL 215
            ..:.:. .|::....::..|..|||.||::|.:|:..:||||:.:| ...||..||:|.||||..
Mouse    80 QLQGEELRLQEESVKQHQINIYLSDRISLHRRLPERWNPLCREVKYDYDNLPKTSVVIAFYNEAW 144

  Fly   216 SVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARA 280
            |.|:|:|:|::..||..|::|:|||||:||||:|.:.|...:::..| ||::|..||.||:.||.
Mouse   145 STLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSQLPK-VRLIRASRREGLVRARL 208

  Fly   281 AGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQD-EGARGA 344
            .||..|..|||.|||.|.|.:..||.|||:.|...:...|||.|||||...|.|.... |...|.
Mouse   209 LGASAARGEVLTFLDCHCECHEGWLEPLLQRIHEKESAVVCPVIDVIDWNTFEYLGNSGEPQIGG 273

  Fly   345 FDWE--FFYKRLPLLP-EDLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELS 406
            |||.  |.:..:|... :.::.|.|..:||.|||||||:|:.:|..||.||.|:::||||..|.|
Mouse   274 FDWRLVFTWHVVPQRERQSMRSPIDVIRSPTMAGGLFAVSKRYFDYLGSYDTGMEVWGGENLEFS 338

  Fly   407 FKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHK----NYKRVAEVWMDEYKNYLYSHG 467
            |:||.|||.:...|||.:||::         |::..|...    |..|.|||||||:|. ||.|.
Mouse   339 FRIWQCGGTLETHPCSHVGHVF---------PKQAPYSRSKALANSVRAAEVWMDEFKE-LYYHR 393

  Fly   468 DGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYP----PVDPPSYAMGALQNVGNQ 528
            :........||:||:|.:|.||.||.||||::.|       ||    |.|.|.: .|.|||.|.:
Mouse   394 NPQARLEPFGDVTERKKLRAKLQCKDFKWFLDTV-------YPELHVPEDRPGF-FGMLQNRGLR 450

  Fly   529 NLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWD 593
            ..|||.....:::..|                                          ..|.|:.
Mouse   451 GYCLDYNPPNENHVEG------------------------------------------HQVLLYL 473

  Fly   594 CHSQGGNQYWYYDYRHKQLKHGT----------EGR------RCLELLPFSQEVV---------- 632
            ||..|.||::.|..| |::::.|          :|:      .|.|.:|.:||.:
Mouse   474 CHGMGQNQFFEYTTR-KEIRYNTRQPEACITVEDGKDTLVMDLCRETVPENQEFILQEDGTLVHK 537

  Fly   633 -ANKC------DTDNRF------------QQWNF 647
             :.||      ..||.|            |:|.|
Mouse   538 HSRKCVEATEKVLDNGFAPYLRDCTNSDNQRWFF 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	135/304 (44%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	35/178 (20%)
Galnt12	NP_766281.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..58		4/17 (24%)
		Catalytic subdomain A	130..239		55/109 (50%)
		pp-GalNAc-T	134..428	CDD:133004	136/311 (44%)
		Catalytic subdomain B	299..361		33/70 (47%)
		beta-trefoil_Ricin-like	438..574	CDD:483949	35/178 (20%)