Protein Alignment Pgant6 and Galnt6

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_766039.2
• Gene: Galnt6 / 207839
• MGIID: 1891640
• Length: 622
• Species: Mus musculus
• Alignment Length: 632
• Identity: 223/632 - (35%)
• Similarity: 314/632 - (49%)
• Gaps: 97/632 - (15%)

  Fly    62 PAIKQPEPQKPQEPDF---------EEDPELQKIDEPEPVEEEVDNPH--------PADDEP--Q 107
            |.:|....||.|..||         :..|:|| |..|||.:..|...|        ||:.:|  .
Mouse    41 PWLKSLAGQKDQVLDFMLGAVNNIRDVMPKLQ-IRAPEPPQTLVSTNHSCLPGFYTPAELKPFWD 104

  Fly   108 QQPQEELQMAAPADASVKKDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNA 172
            :.||:.....|...|..||:|.:....||:       ||.|                  ::.|||
Mouse   105 RPPQDPNSPGADGKAFQKKEWTNLETKEKE-------EGYK------------------KHCFNA 144

  Fly   173 LLSDSISVNRSV-PDIRHPLC--RKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELM 234
            ..||.||:.||: ||.|.|.|  :|......|||.||||:|:||..|.|:|:|:|:::.||..|:
Mouse   145 FASDRISLQRSLGPDTRPPECVDQKFRRCPPLPTTSVIIVFHNEAWSTLLRTVYSVLHTSPAILL 209

  Fly   235 KEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVE 299
            ||||||||.|..|:|.:.||.|: :..:.|||||...|.|||.||..||..|.||||.|||:|.|
Mouse   210 KEIILVDDASTDEHLKERLEQYV-QQLQIVRVVRQRERKGLITARLLGASVAQAEVLTFLDAHCE 273

  Fly   300 ANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHY-RAQDEG---ARGAFDWEFFYKRLPLLPED 360
            ..:.||.|||..||.:|...|.|.|..||...|.: |....|   :||.|||...: ...:|||.
Mouse   274 CFHGWLEPLLARIAEDKTAVVSPDIVTIDLNTFQFSRPVQRGKAHSRGNFDWSLTF-GWEMLPEH 337

  Fly   361 ----LKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPC 421
                .|....|.|||..|||||:||:.:|..:|.||..::|||||..|:||::|.|||::...||
Mouse   338 EKQRRKDETYPIKSPTFAGGLFSISKAYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPC 402

  Fly   422 SRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDP---GDLTEQK 483
            |.:||::|....| ..|:....:.:|..|:||||||:||...|.......:.|..   ||::|:.
Mouse   403 SVVGHVFRTKSPH-TFPKGTSVIARNQVRLAEVWMDDYKKIFYRRNLQAAKMVQENNFGDISERL 466

  Fly   484 AIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMG---- 544
            .:|.:|.|.:|.|::..|..::.  .|.::|..|  ||::|:|. |.|||.   .::|:.|
Mouse   467 RLREQLRCHNFSWYLHNVYPEMF--VPDLNPTFY--GAIKNLGT-NQCLDV---GENNRGGKPLI 523

  Fly   545 MYACADNIKTPQRTQFWELSWKRDLRLRRKKE-CLDVQIWDANAPVWLWDCHSQGGN------QY 602
            ||.| .|:   ...|::|.:.:||||....|: ||..    :.:.:.|..|...|.|      :.
Mouse   524 MYVC-HNL---GGNQYFEYTSQRDLRHNIGKQLCLHA----SGSTLGLRSCQFVGKNSRVPKDEE 580

  Fly   603 WYYDYRHKQLKHGTEGRRCLELLPFSQE--VVANKCDTDNRFQQWNF 647
            |  :....||...:....||.    ||:  .....|:..:.:|.|.|
Mouse   581 W--ELTQDQLIRNSGSGTCLT----SQDKKPAMAPCNPRDPYQLWLF 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	132/307 (43%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	39/146 (27%)
Galnt6	NP_766039.2	Catalytic subdomain A	176..285		60/109 (55%)
		pp-GalNAc-T	180..485	CDD:133004	132/307 (43%)
		Catalytic subdomain B	348..410		32/61 (52%)
		beta-trefoil_Ricin-like	495..622	CDD:483949	40/147 (27%)