Protein Alignment Pgant6 and Galnt10

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_598950.2
• Gene: Galnt10 / 171212
• MGIID: 1890480
• Length: 603
• Species: Mus musculus
• Alignment Length: 581
• Identity: 282/581 - (48%)
• Similarity: 359/581 - (61%)
• Gaps: 58/581 - (9%)

  Fly   117 AAPADASVK------------------KDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKR 163
            ||.|.|:|:                  ||||:...:.:||:|||.||.||...:.|..:.|...|
Mouse    45 AAVAPAAVQELHSRQKKTFFLGAEQRLKDWHNKEAIRRDAQRVGYGEQGKPYPMTDAERVDQAYR 109

  Fly   164 MSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINR 228
               |||||..:||.||:|||:||||||.|..|.|:..||..|:||.|:||..|.|:|:|||::||
Mouse   110 ---ENGFNIYVSDKISLNRSLPDIRHPNCNSKLYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNR 171

  Fly   229 SPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIF 293
            |||||:.||:||||.||||:|.|.||.|:| .|..||::|..:|.|||..|..||..||.:|:.|
Mouse   172 SPPELVAEIVLVDDFSDREHLKKPLEDYMA-LFPSVRILRTKKREGLIRTRMLGASAATGDVVTF 235

  Fly   294 LDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQ-DEGARGAFDWEFFYKRLPLL 357
            ||||.|||.|||||||:.||.|::|.|||.||||||.:|.|..| .:..|||||||.:|||:|:.
Mouse   236 LDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIP 300

  Fly   358 PEDLK-HPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPC 421
            ||..| .|:|||:||:|||||||:.|::||||||||.||:||||||||:|||:|||||.|.|.||
Mouse   301 PELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPC 365

  Fly   422 SRIGHIYRGPRNHQPSPRK---GDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQK 483
            ||:|||||     :..|.|   |..|.:|.|||||||||||..|:|..... |..:..||:..||
Mouse   366 SRVGHIYR-----KYVPYKVPAGVSLARNLKRVAEVWMDEYAEYIYQRRPE-YRHLSAGDVVAQK 424

  Fly   484 AIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYAC 548
            .:|..||||||||||.::|:||.|.||||:||:.|.|.::|||. .||.||       |:|....
Mouse   425 KLRVSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGT-GLCTDT-------KLGTLGS 481

  Fly   549 ADNIKTPQR---------TQFWELSWKRDLR----LRRKKECLDVQIWDANAPVWLWDCHSQGGN 600
            ...::|..|         .|.:..:|:.|:|    ...||.|.|..  ...:||.|:||||..||
Mouse   482 PLRLETCIRGRGEAAWNSMQVFTFTWREDIRPGDPQHTKKFCFDAV--SHTSPVTLYDCHSMKGN 544

  Fly   601 QYWYYDYRHKQLKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQWNFGSFNKTALDNYSQD 661
            |.|.| .:.|.|.|...| .|::.......|..|.|:..:..|||.|...|.|.|:|::::
Mouse   545 QLWKY-RKDKTLYHPVSG-SCMDCSESDHRVFMNTCNPSSLTQQWLFEHTNSTVLENFNKN 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	179/301 (59%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	45/145 (31%)
Galnt10	NP_598950.2	Catalytic subdomain A	144..253		66/109 (61%)
		pp-GalNAc-T	148..443	CDD:133004	179/301 (59%)
		Catalytic subdomain B	311..373		47/61 (77%)
		Flexible loop. /evidence=ECO:0000250	373..384		3/15 (20%)
		beta-trefoil_Ricin_GALNT10	454..603	CDD:467354	51/160 (32%)