DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and GALNTL5

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_016867282.1	Gene:	GALNTL5 / 168391	HGNCID:	21725	Length:	496	Species:	Homo sapiens

Alignment Length:	347	Identity:	146/347 - (42%)
Similarity:	214/347 - (61%)	Gaps:	10/347 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 DLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVH 223
            :|.|.: |:.|||.::|.|:.:.|.|||.|..:|.:|.|.|:|||.|::|.||||..:.|.:::.
Human   145 ELHKEL-LKYGFNVIISRSLGIEREVPDTRSKMCLQKHYPARLPTASIVICFYNEECNALFQTMS 208

  Fly   224 SLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKW-VRVVRLPRRTGLIGARAAGARNAT 287
            |:.|.:|...::|||||||.|..:.|.::|: |..|.|:. |:::|..:|.|||.||..||.:|:
Human   209 SVTNLTPHYFLEEIILVDDMSKVDDLKEKLD-YHLETFRGKVKIIRNKKREGLIRARLIGASHAS 272

  Fly   288 AEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDWEFFYK 352
            .:||:|||||.|.|..||.|||..||.:.:..|||.|||||.....|:.... .||.|||...:|
Human   273 GDVLVFLDSHCEVNRVWLEPLLHAIAKDPKMVVCPLIDVIDDRTLEYKPSPL-VRGTFDWNLQFK 336

  Fly   353 RLPLLPEDLKHP---ADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGG 414
            ...:...::..|   ..|.:||.|:||:|||.|.:|.|:|.||:.:|.||.|..|||.:||||||
Human   337 WDNVFSYEMDGPEGSTKPIRSPAMSGGIFAIRRHYFNEIGQYDKDMDFWGRENLELSLRIWMCGG 401

  Fly   415 EMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDL 479
            :::..||||:|||.: .:..:||.......| ||.|:..||:||||...:....|| :.|..|::
Human   402 QLFIIPCSRVGHISK-KQTGKPSTIISAMTH-NYLRLVHVWLDEYKEQFFLRKPGL-KYVTYGNI 463

  Fly   480 TEQKAIRTKLNCKSFKWFMEEV 501
            .|:..:|.:|.||||:|:::.|
Human   464 RERVELRKRLGCKSFQWYLDNV 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	95/217 (44%)
		pp-GalNAc-T	205..502	CDD:133004	126/301 (42%)
		RICIN	520..647	CDD:238092
		Ricin_B_lectin	520..645	CDD:279046
GALNTL5	XP_016867282.1	GT2	187..437	CDD:224137	109/253 (43%)
GALNTL5	XP_016867282.1	pp-GalNAc-T	190..486	CDD:133004	126/301 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740