Protein Alignment Pgant6 and Galnt4

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_056552.1
• Gene: Galnt4 / 14426
• MGIID: 894692
• Length: 578
• Species: Mus musculus
• Alignment Length: 646
• Identity: 217/646 - (33%)
• Similarity: 309/646 - (47%)
• Gaps: 145/646 - (22%)

  Fly     8 WIVKASLLLLISLTLFVLITSWISSTPYTNKPVHHGVEPVPEKAGLSGDVKVKVPAIKQPEPQKP 72
            |..|:.|||.: |||..::..:..||.|.:.......|..|.:.
Mouse     7 WAGKSCLLLAL-LTLAYILVEFSVSTLYASPGAGGARELGPRRL--------------------- 49

  Fly    73 QEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTFMEKD 137
              ||.:..            ||::..|              |.:..|||:.
Mouse    50 --PDLDTR------------EEDLSQP--------------LYIKPPADSH-------------- 72

  Fly   138 AKRVGLGEGGKASTL-----DDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCR-KKE 196
                .|||.|:||.|     :.:.|.:|.:|.::    |..|||.||::|.:.|.|...|: ||.
Mouse    73 ----ALGEWGRASKLQLNEGELKQQEELIERYAI----NIYLSDRISLHRHIEDKRMYECKAKKF 129

  Fly   197 YVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHF 261
            :...|||.||||.||||..|.|:|::||::..||..|:||||||||.|||.||..:|||||: :.
Mouse   130 HYRSLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRIYLKAQLETYIS-NL 193

  Fly   262 KWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDV 326
            :.||::|..:|.||:.||..||..||.:||.|||.|.|.|..||.||||.|:.::...|||.||.
Mouse   194 ERVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNTGWLEPLLERISRDETAIVCPVIDT 258

  Fly   327 IDHTNFHYRAQ-DEGARGAFDWE--FFYKRLPLLPEDLK-HPADPFKSPIMAGGLFAISREFFWE 387
            ||...|.:..| .|...|.|||.  |.:..:|....|.: ...||.:||.|||||||:|:::|..
Mouse   259 IDWNTFEFYMQTGEPMIGGFDWRLTFQWHSVPKHERDRRTSRIDPIRSPTMAGGLFAVSKKYFQY 323

  Fly   388 LGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNY---- 448
            ||.||.|:::||||..||||::|.|||::...|||.:||::         |::..|...|:
Mouse   324 LGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVF---------PKRAPYARPNFLQNT 379

  Fly   449 KRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVD 513
            .|.|||||||||.:.|:......:.. .|||:|:|.:|.:|.||||.|:::.|..:|   :.|.|
Mouse   380 ARAAEVWMDEYKEHFYNRNPPARKEA-YGDLSERKLLRERLKCKSFDWYLKNVFSNL---HVPED 440

  Fly   514 PPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECL 578
            .|.: .||::::|..:.|||            |...||..|
Mouse   441 RPGW-HGAIRSMGISSECLD------------YNAPDNNPT------------------------ 468

  Fly   579 DVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLELLPFSQEVVANKCDTD 639
                   .|.:.|:.||.|||||::.|. .:|:::..:....|.|:......|....|..|
Mouse   469 -------GANLSLFGCHGQGGNQFFEYT-SNKEIRFNSVTELCAEVPQQKDYVGMQNCPKD 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	139/304 (46%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	27/125 (22%)
Galnt4	NP_056552.1	Catalytic subdomain A	134..243		62/109 (57%)
		pp-GalNAc-T	138..432	CDD:133004	139/304 (46%)
		Catalytic subdomain B	303..365		34/70 (49%)
		beta-trefoil_Ricin-like	442..577	CDD:483949	27/125 (22%)