Protein Alignment Pgant6 and Galnt3

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_056551.2
• Gene: Galnt3 / 14425
• MGIID: 894695
• Length: 633
• Species: Mus musculus
• Alignment Length: 692
• Identity: 227/692 - (32%)
• Similarity: 330/692 - (47%)
• Gaps: 135/692 - (19%)

  Fly     8 WIVKASLLLLISLTLFVLITSWISSTPYT-------------NKPVHHGVEPVPEKAGLSGDVKV 59
            |  |...::...|.:.:|:...: |..|:             ||.:...:|.|       .::|.
Mouse    21 W--KLGAVIFFFLVVLILMQREV-SVQYSKEESKMERNLKNKNKMLDFMLEAV-------NNIKD 75

  Fly    60 KVPAIKQPEPQKPQEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASV 124
            .:|.::...|.| :..|..|.|.||.......::...|.|          ||:.   .||..:
Mouse    76 AMPKMQIGAPIK-ENIDVRERPCLQGYYTAAELKPVFDRP----------PQDS---NAPGAS-- 124

  Fly   125 KKDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSV-PDIR 188
                               |:..|.:.|..|.|::.| |...::.|||..||.||::|.: ||.|
Mouse   125 -------------------GKPFKITHLSPEEQKEKE-RGETKHCFNAFASDRISLHRDLGPDTR 169

  Fly   189 HPLCRKKEY--VAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGK 251
            .|.|.::::  ...|||.||||:|:||..|.|:|:|||::..||..|:||||||||.|..:||.:
Mouse   170 PPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDDYLHE 234

  Fly   252 ELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNK 316
            :||.|| :.|..|::||...|.|||.||..||..||||.|.|||:|.|..|.||.|||..||.|.
Mouse   235 KLEEYI-KQFSIVKIVRQQERKGLITARLLGAAVATAETLTFLDAHCECFYGWLEPLLARIAENY 298

  Fly   317 RTAVCPFIDVIDHTNFHY-RAQDEGA---RGAFDW--EFFYKRLPLLPEDLKHPAD---PFKSPI 372
            ...|.|.|..||...|.: :....|:   ||.|||  .|.::.||  ..:.:...|   |.|:|.
Mouse   299 TAVVSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLP--DHEKQRRKDETYPIKTPT 361

  Fly   373 MAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPS 437
            .|||||:||:::|..:|.|||.::|||||..|:||::|.|||::...|||.:||::|....| ..
Mouse   362 FAGGLFSISKKYFEHIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPH-TF 425

  Fly   438 PRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDP---GDLTEQKAIRTKLNCKSFKWFME 499
            |:....:.:|..|:|||||||||...|.......:.|..   |||:::..|:.:|.||:|.|::.
Mouse   426 PKGTQVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLN 490

  Fly   500 EVAFDLMKTYPPVDPPS---YAMGALQNVGNQNLCLDTLGRKKHNKMG----MYAC---ADNIKT 554
            .:       ||....|.   ...|.:::|| |.||||.   .::|:.|    :|.|   ..|
Mouse   491 TI-------YPEAYVPDLNPVISGYIKSVG-QPLCLDV---GENNQGGKPLILYTCHGLGGN--- 541

  Fly   555 PQRTQFWELSWKRDLRLRRKKE-CLDVQIWDANAPVWLWDCHSQG------GNQYWYYDYRHKQL 612
                |::|.|.:|::|...:|| ||..    ....|.|..|..:|      |.|.|  :.|..||
Mouse   542 ----QYFEYSAQREIRHNIQKELCLHA----TQGVVQLKACVYKGHRTIAPGEQIW--EIRKDQL 596

  Fly   613 KHGTEGRRCL-------ELLPFSQEVVANKCDTDNRFQQWNF 647
            .:....:.||       .|:|         ||..:..|:|.|
Mouse   597 LYNPLFKMCLSSNGEHPNLVP---------CDATDLLQKWIF 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	135/308 (44%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	42/157 (27%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..145		13/67 (19%)
		Catalytic subdomain A	184..293		62/109 (57%)
		pp-GalNAc-T	188..493	CDD:133004	135/315 (43%)
		Catalytic subdomain B	356..418		32/61 (52%)
		beta-trefoil_Ricin-like	502..630	CDD:483949	41/154 (27%)