Protein Alignment Pgant6 and GALNT15

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_473451.3
• Gene: GALNT15 / 117248
• HGNCID: 21531
• Length: 639
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 209/691 - (30%)
• Similarity: 325/691 - (47%)
• Gaps: 118/691 - (17%)

  Fly    14 LLLLISLTLFVLITSWISSTPYTNKPVHHGVEPVPEKAGLSGDVKVKVPAIKQPEPQKPQEPDFE 78
            ||||:.|...:::.:.:       .|.||.:...           |...|.|. .|:.....||.
Human    17 LLLLLMLGCVLMMVAML-------HPPHHTLHQT-----------VTAQASKH-SPEARYRLDFG 62

  Fly    79 EDPE--LQKIDEPE---PVE---------EE-----VDNPHPADDEPQ----------QQPQEEL 114
            |..:  |:..||.|   |:|         |:     |..|....::.|          :||:.:
Human    63 ESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLIKQPRRQ- 126

  Fly   115 QMAAPADASVKKDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSIS 179
            ...||     |:||             |..|.|:.|..::.:...|:.|     |....||..|.
Human   127 DKEAP-----KRDW-------------GADEDGEVSEEEELTPFSLDPR-----GLQEALSARIP 168

  Fly   180 VNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHS 244
            :.|::|::|||||.::.....|||.|||:.|::|..|.|:|:|||:::..|...:||||||||.|
Human   169 LQRALPEVRHPLCLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLS 233

  Fly   245 DREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLL 309
            .:..|...|..|:| ..:.|:::|..:|.|.|.||..||..||.:||:|:|:|.|.:..||.|||
Human   234 QQGQLKSALSEYVA-RLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLL 297

  Fly   310 EPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDWEFFYKRLPLLPED----LKHPADPFKS 370
            ..||.::...|.|.|||||...|.|....:..||..||:..:...| |||.    |:.|..|.:|
Human   298 SRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEP-LPEHVRKALQSPISPIRS 361

  Fly   371 PIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQ 435
            |::.|.:.|:.|.:|...|.||..:.:.|||..|||||.|:|||.:...||||:||||:...:|.
Human   362 PVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQNQDSHS 426

  Fly   436 PSPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLY--ESVDPGDLTEQKAIRTKLNCKSFKWFM 498
            |..::...  :|..|:||.|:..:|...|.|....:  ...:..|..|:..::.:|.|::|.||:
Human   427 PLDQEATL--RNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFL 489

  Fly   499 EEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCL------DTLGRKKHNKMGMYACADNIKTPQR 557
            ..|..:|   ||....||:: |.|.|.| ..||.      |.||    ..|.:..|:|:    ::
Human   490 ANVYPEL---YPSEPRPSFS-GKLHNTG-LGLCADCQAEGDILG----CPMVLAPCSDS----RQ 541

  Fly   558 TQFWELSWKRDLRLRRKKE-CLDVQIWDANAPVWLWDCHSQG---GNQYWYYDYRHK-QLKHGTE 617
            .|:.:.:.::::.....:. |..|:    ...|.|.:|..:|   ..|:|  |::.. .:.|...
Human   542 QQYLQHTSRKEIHFGSPQHLCFAVR----QEQVILQNCTEEGLAIHQQHW--DFQENGMIVHILS 600

  Fly   618 GRRCLELL--PFSQEVVANKCDTDNRFQQWNFGSFNKTALD 656
            | :|:|.:  ..::::....||...| |||.|...|  |:|
Human   601 G-KCMEAVVQENNKDLYLRPCDGKAR-QQWRFDQIN--AVD 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	115/302 (38%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	34/145 (23%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..155		12/67 (18%)
		Catalytic subdomain A	190..299		50/109 (46%)
		pp-GalNAc-T	194..493	CDD:133004	115/302 (38%)
		Catalytic subdomain B	358..420		29/61 (48%)
		beta-trefoil_Ricin_GALNT15	502..629	CDD:467320	33/144 (23%)