Protein Alignment Pgant6 and GALNT5

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_016858726.1
• Gene: GALNT5 / 11227
• HGNCID: 4127
• Length: 956
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 221/598 - (36%)
• Similarity: 312/598 - (52%)
• Gaps: 71/598 - (11%)

  Fly    90 EPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWH-DYTFMEKDAKRVGLGEGGKASTLD 153
            ||.:..:....|:    .:..|..::...|.|:...:... |.|...:|.|  ..|:.|:...:.
Human   390 EPAKINITAKAPS----TEYNQSHIKALLPEDSGTHQVLRIDVTLSPRDPK--APGQFGRPVVVP 448

  Fly   154 DESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVL 218
            ...:::.|:|.. |..||..|||.|.|:|::.|.|...|.::.....|||.|||:.|.:|..|.|
Human   449 HGKEKEAERRWK-EGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNNLPTTSVIMCFVDEVWSTL 512

  Fly   219 MRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGA 283
            :|||||:||||||.|:|||:||||.|.::||...|:.|::: |..||::||..|.|||.||.|||
Human   513 LRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQ-FPKVRILRLKERHGLIRARLAGA 576

  Fly   284 RNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDW- 347
            :|||.:||.|||||||.|..||.||||.:.|:::...||.|:||:..:..|...|...||.|.|
Human   577 QNATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKDMSYMTVDNFQRGIFVWP 641

  Fly   348 -EFFYKRLP--LLPEDLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKI 409
             .|.::.:|  ::.::.....|..:.|:||||||:|.:.:|:|||.||.|||:||||..|||||:
Human   642 MNFGWRTIPPDVIAKNRIKETDTIRCPVMAGGLFSIDKSYFFELGTYDPGLDVWGGENMELSFKV 706

  Fly   410 WMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLY-ES 473
            ||||||:...||||:|||:|....:.....:...:.:|..||||||:||||...|.|||.|. :.
Human   707 WMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDEYKELFYGHGDHLIDQG 771

  Fly   474 VDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGR- 537
            :|.|:||:|:.:|.||.||||||::|.|..||..      |...|.|.|.||        .||:
Human   772 LDVGNLTQQRELRKKLKCKSFKWYLENVFPDLRA------PIVRASGVLINV--------ALGKC 822

  Fly   538 -KKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQ 601
             ...|...:....|..|..|:..:   :|   |||.:..|.....|.|..| |.|..|.::....
Human   823 ISIENTTVILEDCDGSKELQQFNY---TW---LRLIKCGEWCIAPIPDKGA-VRLHPCDNRNKGL 880

  Fly   602 YWYYDYRHK------------------------QLKH----GTEGRRCLELLPFSQEVV-ANKCD 637
            .|.    ||                        |:.|    ..:...||| ..|||::: ...||
Human   881 KWL----HKSTSVFHPELLSNSACGSFPALLSLQVNHIVFENNQQLLCLE-GNFSQKILKVAACD 940

  Fly   638 TDNRFQQWNFGSF 650
            ....:|:|.|..:
Human   941 PVKPYQKWKFEKY 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	150/301 (50%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	37/163 (23%)
GALNT5	XP_016858726.1	pp-GalNAc-T	499..800	CDD:133004	150/301 (50%)
		beta-trefoil_Ricin_GALNT5	806..954	CDD:467314	39/168 (23%)