Protein Alignment Pgant6 and GALNT6

DIOPT Version :10

• Sequence 1: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_009141.2
• Gene: GALNT6 / 11226
• HGNCID: 4128
• Length: 622
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 205/580 - (35%)
• Similarity: 294/580 - (50%)
• Gaps: 87/580 - (15%)

  Fly   101 PADDEP--QQQPQEELQMAAPADASVKKDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKR 163
            ||:.:|  ::.||:.....|...|..|..|......||:       ||.|
Human    96 PAELKPFWERPPQDPNAPGADGKAFQKSKWTPLETQEKE-------EGYK--------------- 138

  Fly   164 MSLENGFNALLSDSISVNRSV-PDIRHPLC--RKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSL 225
               ::.|||..||.||:.||: ||.|.|.|  :|......|.|.||||:|:||..|.|:|:|:|:
Human   139 ---KHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPLATTSVIIVFHNEAWSTLLRTVYSV 200

  Fly   226 INRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEV 290
            ::.:|..|:||||||||.|..|:|.::||.|: :..:.|||||...|.|||.||..||..|.|||
Human   201 LHTTPAILLKEIILVDDASTEEHLKEKLEQYV-KQLQVVRVVRQEERKGLITARLLGASVAQAEV 264

  Fly   291 LIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHY-RAQDEG---ARGAFDWE--F 349
            |.|||:|.|..:.||.|||..||.:|...|.|.|..||...|.: :....|   :||.|||.  |
Human   265 LTFLDAHCECFHGWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFAKPVQRGRVHSRGNFDWSLTF 329

  Fly   350 FYKRLPLLPEDLKHPAD---PFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWM 411
            .::.||  |.:.:...|   |.|||..|||||:||:.:|..:|.||..::|||||..|:||::|.
Human   330 GWETLP--PHEKQRRKDETYPIKSPTFAGGLFSISKSYFEHIGTYDNQMEIWGGENVEMSFRVWQ 392

  Fly   412 CGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMDEYKNYLYS---HGDGLYES 473
            |||::...|||.:||::|....| ..|:....:.:|..|:||||||.||...|.   ....:.:.
Human   393 CGGQLEIIPCSVVGHVFRTKSPH-TFPKGTSVIARNQVRLAEVWMDSYKKIFYRRNLQAAKMAQE 456

  Fly   474 VDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRK 538
            ...||::|:..:|.:|:|.:|.|::..|..::.  .|.:.|..|  ||::|:|. |.|||.   .
Human   457 KSFGDISERLQLREQLHCHNFSWYLHNVYPEMF--VPDLTPTFY--GAIKNLGT-NQCLDV---G 513

  Fly   539 KHNKMG----MYAC---ADNIKTPQRTQFWELSWKRDLRLRRKKE-CLDVQIWDANAPVWLWDCH 595
            ::|:.|    ||:|   ..|       |::|.:.:||||....|: ||.|    :...:.|..||
Human   514 ENNRGGKPLIMYSCHGLGGN-------QYFEYTTQRDLRHNIAKQLCLHV----SKGALGLGSCH 567

  Fly   596 SQGGN------QYWYYDYRHKQLKHGTEGRRCLELLPFSQE--VVANKCDTDNRFQQWNF 647
            ..|.|      :.|  :....||...:....||.    ||:  .....|:..:..|.|.|
Human   568 FTGKNSQVPKDEEW--ELAQDQLIRNSGSGTCLT----SQDKKPAMAPCNPSDPHQLWLF 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	130/308 (42%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	41/149 (28%)
GALNT6	NP_009141.2	Catalytic subdomain A	176..285		58/109 (53%)
		pp-GalNAc-T	180..485	CDD:133004	130/308 (42%)
		Catalytic subdomain B	348..410		32/61 (52%)
		beta-trefoil_Ricin_GALNT6	495..622	CDD:467348	42/150 (28%)