DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant6 and Galnt7

DIOPT Version :9

Sequence 1:	NP_001261342.1	Gene:	Pgant6 / 38346	FlyBaseID:	FBgn0035375	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001161453.1	Gene:	Galnt7 / 108150	MGIID:	1349449	Length:	657	Species:	Mus musculus

Alignment Length:	692	Identity:	233/692 - (33%)
Similarity:	351/692 - (50%)	Gaps:	100/692 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SLLLLISLTLFVLITSWISSTPYTNKPVHHGVE------PVPEKAG---LSGDVKVKVPAIKQPE 68
            |||::.|....|::.|.:||.|....|:....|      |:|.:.|   ..||.:.| |.:..|.
Mouse    11 SLLVVGSFLGLVVLWSSLSSRPDDQSPLSRMREDRDVNNPLPNRGGNGLAPGDDRFK-PVVPWPH 74

  Fly    69 PQKPQEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTF 133
            .:       ..:.:|:.|......:.|.:. |...|..:...|.:.....|           .||
Mouse    75 VE-------GVEVDLESIRRKNKAKNEQER-HAGGDSQRDVMQRQYLTFKP-----------QTF 120

  Fly   134 MEKD-AKRVGL------------------GEGGKASTLDDESQRDLEKRMSLENGFNALLSDSIS 179
            ..:| ..|.|:                  ||..|...|..|.::.::..:. |.|||.:.||.||
Mouse   121 TYRDPVLRPGVLGNFEPKEPEPHGVVGGPGEKAKPLVLGPEYKQAVQASIK-EFGFNMVASDMIS 184

  Fly   180 VNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHS 244
            ::|||.|:|...|:...|...|.|.||:|:|:||..|.|||:|||:|.|:|.:.:.||:|:||.|
Mouse   185 LDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFS 249

  Fly   245 DREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNA-TAEVLIFLDSHVEANYNWLPPL 308
            ::|:|.::|:.||......|:|.|..||.|||.||:.||:.| ..:|||:||:|.|...||..||
Mouse   250 NKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPL 314

  Fly   309 LEPIALNKRTAVCPFIDVIDHTNFHYRAQDEG-----ARGAFDWEFFYKRLPLLPED---LKHPA 365
            :.||:.::.|...|.||.||..::....|..|     ||||:||...:||:||..::   .||..
Mouse   315 VAPISKDRATCTVPLIDYIDGNDYSIEPQQGGDEDGFARGAWDWSMLWKRIPLSHKEKAKRKHKT 379

  Fly   366 DPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYR- 429
            :|::||.||||||||.::||:|||.||.||.|||||.:|:|:|||.|||::...||||:|||||
Mouse   380 EPYRSPAMAGGLFAIEKDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRL 444

  Fly   430 -GPRNHQP------SPRKGDYLHKNYKRVAEVWMDEYKNYLY-SHGDGLYESVDPGDLTEQKAIR 486
             |.:.:.|      ||..     |||.||.|||.||||:|.| |..:.  :::..||::|.|..|
Mouse   445 EGWQGNPPPLYVGSSPTL-----KNYVRVVEVWWDEYKDYFYASRPES--KALPYGDISELKKFR 502

  Fly   487 TKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADN 551
            ...|||||||||||:|:|:...| |:.|.:...|.::.: ....|:|::|:.....:.:..|
Mouse   503 EDHNCKSFKWFMEEIAYDITAHY-PLPPRNVEWGEIRGL-ETAYCIDSMGKTNGGFVELGPC--- 562

  Fly   552 IKTPQR---TQFWELSWKRDLRLRRKKECLDVQIWDANAP----VWLWDCHSQGGNQYWYYDYRH 609
                .|   .|.:.::...  :|.:..:||      ...|    |.:..|:.....::.|:...|
Mouse   563 ----HRMGGNQLFRINEAN--QLMQYDQCL------TKGPDGSKVMITHCNLNEFKEWQYFKSLH 615

  Fly   610 KQLKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQWNFGSFN 651
            : ..|.|.| :||:......:|..:.||:....|:|...:.:
Mouse   616 R-FTHITSG-KCLDRSEVLHQVFISTCDSSKMTQKWEMNNIH 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant6	NP_001261342.1	BcsA	199..>413	CDD:224136	105/222 (47%)
		pp-GalNAc-T	205..502	CDD:133004	150/314 (48%)
		RICIN	520..647	CDD:238092	25/133 (19%)
		Ricin_B_lectin	520..645	CDD:279046	24/131 (18%)
Galnt7	NP_001161453.1	pp-GalNAc-T	210..518	CDD:133004	150/314 (48%)
		BcsA	210..>438	CDD:224136	109/227 (48%)
		Ricin_B_lectin	534..649	CDD:279046	24/132 (18%)
		RICIN	535..651	CDD:238092	25/133 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48703
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820