DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atg2 and atg2a

DIOPT Version :9

Sequence 1:NP_001261341.1 Gene:Atg2 / 38344 FlyBaseID:FBgn0044452 Length:1906 Species:Drosophila melanogaster
Sequence 2:NP_001072654.1 Gene:atg2a / 780111 XenbaseID:XB-GENE-5818802 Length:1997 Species:Xenopus tropicalis


Alignment Length:2160 Identity:637/2160 - (29%)
Similarity:979/2160 - (45%) Gaps:428/2160 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 WFNPW-DGLKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLFEDQGW 66
            |..|| ..:||:.||||||.|||.:.|..|:||||.:|||||...:.||.|.:.:.|:|.:..|.
 Frog     4 WLFPWSSSIKTRACRYLLQHYLGHYLEERLSLEQLSLDLYNGSGRLTDIHLDIWSVNELLDSAGA 68

  Fly    67 AFEVVSGHIGRLTVVVPWNALMTNDSSLEIHNLTITLRPVTRYQSGTTMLESM-WSS-VSSSMQM 129
            ..|::.|.||.::|.:||:||:|.:.:||:..|.:|.||  :|:......||. ||| :::|||:
 Frog    69 PLEIIDGFIGSISVTIPWSALVTENCTLEVSKLQVTCRP--KYRGAAQGTESQSWSSCMTTSMQL 131

  Fly   130 AEECMKQVDDDVPFLNHNNALIGLEKFAETIDNVLNRIRAKLTNTTLNIEYILPRSDRKLVLSFQ 194
            |:||:|:..::..  .....:.|||.||:||:.||.||:....:|.:.||.....|:....|...
 Frog   132 AQECLKEQPEEPS--EPPQPIEGLEMFAQTIETVLRRIKVTFIDTIVRIENNPGDSNLGTALEIH 194

  Fly   195 ASHVEYKNKTGYEMPMSTSQDTETEEDPNSSFNALPMIAKHNLVIEGLSLHTSEVLDVM------ 253
            ...::|.::...:.|.:...|          .:..|...:..|.:.|:|||..|....:      
 Frog   195 IKRLDYCDEAVRDSPHTVPVD----------IHQPPAFIQKILQLSGVSLHYEEFKTSVQTPSPT 249

  Fly   254 --------------------DHQFGPTPYEQLCKIVELKGAQNIQINIKQTENIVGPKVSLELSL 298
                                :.|..|:|.:|   |....|...:.|.:||.:...|||:.::..:
 Frog   250 PENPLESEPVQPSKTPSWPEEPQPAPSPIQQ---IGSCSGCTELTIKLKQNDLFPGPKLDIDGKI 311

  Fly   299 DDIYFMLTPRQIHLLIEFSKGFNCGGQ---QERPKKGR----------------SLKSAPPSEY- 343
            ..::..||||||..|.|.....:....   :|:..|.|                .|:|.|.|.: 
 Frog   312 GSVHLFLTPRQISNLQEILDALSISESSAIREKLLKSRPLDLEDLKLIEQDLNQQLQSGPGSLFV 376

  Fly   344 ---------------QMHSLQQPTR-MTGILGQNADWCTGMSEAD--PSEYSVYGNPPRSGYARS 390
                           ..:|:...|. ||.|...|.     :|:.|  .|.||.|.:.........
 Frog   377 PDPELVPFQTIENGDMFYSMAAMTNSMTSIRSANE-----LSDIDLESSMYSDYSSQQIPSLTPG 436

  Fly   391 RKMSESTNSMVTSCTNTLQQEL----GYTE--KSGEILKFKVQISKIYG------------IALH 437
            ..:|.......|..:.||.|.|    |.:.  .|.|:||.::.:....|            |:..
 Frog   437 IMLSSPRKYGRTPFSATLPQNLHKLPGKSSHPPSMELLKPEMLLRLTLGGLTVTVPHISTYISPQ 501

  Fly   438 QDILIQNTANIDSCSTVFDHASYLR----YSDTA-SGFFLGTL---LENHIPLQNQQYLLLRAAP 494
            :|         .:|..|..|  :.|    :.|:| ||.....|   .|....|.|     :|...
 Frog   502 ED---------PACPEVARH--FFRELGYFKDSAFSGRDFSHLRGQFEKACHLSN-----IRVTA 550

  Fly   495 IIV---------SGSQQRYFQELTSRTTLSATAVDLIEVLDNSKE-----------HLLQF---- 535
            :.|         .|:.|       |...||...::::|.|...:.           .|:.|    
 Frog   551 VAVQLVCEQRVGGGTHQ-------SSVDLSCGRLEILECLRQGESTSRRTKNTEYTKLMTFCSPS 608

  Fly   536 DRQRNCPDGYHIRPEIVLTQSSSFMFKQNHNRCSNKIECSLDECTAELDISIYDRLGALFGS--- 597
            ...|.|...::.|.:...|:||.   |:...:.|::|...|:|...::|:.:.||||::|.:   
 Frog   609 TSSRPCAQIHYKRSQKTPTRSSR---KKQEIKVSSEILVELEEFQTDIDLGLLDRLGSIFQNGAC 670

  Fly   598 -SPFSGDSASSTPYPDDPNQTEFVVKSENLRLHLRFPVVDGRAANDPLKIPWWKKNVRRDFLAVE 661
             ..:|.:....|..|......|..|.:....:.|:|||.|.|.:.:  :.||.:|.||:|.|.:|
 Frog   671 RESYSQNDLHMTDVPQSSEDMEIRVVASKSHICLQFPVPDLRPSLE--RRPWAEKAVRKDCLQME 733

  Fly   662 FRSLVVSSRS--------QISIVSDELDVFYCDADK---------QSAVHLLKC----------- 698
            ...|.:.|:|        :|.|...:|...|.|.:|         :.|..|.|.           
 Frog   734 VADLDIHSQSKTGTDEARKIEITFSDLHGVYTDGEKLNVPCIRVSKGADPLAKAGGKKFIFPSIL 798

  Fly   699 -----QQKMQP-----NKKIQIDVLQLKDTSDGQKKARKSPFSSKCTFGYTSHVEGLDGSVDKTD 753
                 |.|:.|     :|...||...::...: .|:...||||||.|...|.            :
 Frog   799 VAILPQSKVSPWYLAQDKIDDIDHPSVESPCE-LKQPEPSPFSSKRTMFETE------------E 850

  Fly   754 SLLPGETEEINEFCDSCTQSSKLKIFAFIPHVKVVLESKSMYELIYNRLNGDLFMWEPRSPHYDI 818
            .::|.:..|:.:|......||:..:...:|...|...||.:||.:||||..||.||||       
 Frog   851 MVIPADPNEMADFQHVTLASSQYTLEITLPRAHVFFPSKEVYESLYNRLCNDLLMWEP------- 908

  Fly   819 SPDNEVPE------SKDLYAEP------QLEEFR----RNLLLSTSAMESSIYFSMAEPTASAPP 867
                 |||      ...|.|||      |.:.||    ...|.|.|..|.|.::|:.|.......
 Frog   909 -----VPELGASISDSLLSAEPHTTSNYQQDTFRMCKSAFKLDSDSDDEDSHFYSVDEAARHRRG 968

  Fly   868 APPVRNEAFSFELFVEQGTLILFSHLLDPETNQRSKECGKFQVNLKELRLFTVNGLDNDSTRSFF 932
            |...:: .||..:.:.:|.:..::........:.....|:..::::...:|:|:........|:.
 Frog   969 AQDGQS-YFSASVTILKGRITAWTEAKGEGAKKLDDHHGEVVLDVENGCIFSVSKYRGKEDLSYL 1032

  Fly   933 SIQLGEIDALHCGNTLQD------LELAWSDLADEKLLPTIY-NFASVHQQ-----QDRKRMEVL 985
            .|| .|..||:...|::|      ||:. :.|....|.|||| :...|..|     :||.: ::|
 Frog  1033 CIQ-SESVALYHKATVKDYLAPVSLEIP-TFLHPTNLDPTIYLSEEGVSAQLSGARKDRNQ-KML 1094

  Fly   986 SLVAEIKKQPEQRIKRMKMSFGICGAILQHHSCHSEHSWLNQLIDFMDVADFPIEEYEPFALVSE 1050
            ||...|.....:.:|...::..:.||.|:||......||.:|::||:||.|.||..|.|.|:::.
 Frog  1095 SLAVRIDLNLVKNVKEFLVALRLDGATLRHHMALPYQSWHSQILDFLDVVDEPILGYSPPAVITV 1159

  Fly  1051 LQLHVWNAGIDYRPKFFPQRAFLDLGYCTLSSNIISSMSGCTLRLLAEDCVLQLG-LVKEESND- 1113
            |..|:::..:||||.:.|.|..:.....||||||:...|...||.:.:|..|.|. ....|..| 
 Frog  1160 LHTHLFSCAVDYRPLYLPIRVLITAETFTLSSNIVVDTSTFLLRFILDDSALYLSDKCDAEVTDL 1224

  Fly  1114 --SLIPVLNLGLLNI---SFRLNAEGS-GQPRVDLRSSIHDMHLKTCYDSAAALAQLIAYVANDR 1172
              ..:.||::.||.:   :::.||... .||..:||.|.:.:|:.||.||.|.|..|..||.|:.
 Frog  1225 RKDYVCVLDVDLLELVITTWKGNASSKLTQPLFELRCSNNVLHIHTCADSCAMLVNLTQYVMNNG 1289

  Fly  1173 DL-CPPE-EP---ILNEDTKPAE---------PKPNEEHEMSDHTQNHVSKLMADAVIDV----E 1219
            || |||: ||   |..:..:|.|         |....:....|         :.||:||.    :
 Frog  1290 DLHCPPKPEPPTEIAGQKLQPPEGPSSLPPCLPAETAQINQGD---------LTDALIDTGRTGK 1345

  Fly  1220 SSPNLRAMKSPGGREEG-IEIFYFPDEPK--EKRKSTSAKLQTKSLMVESPSVIGDILDFESNVI 1281
            ..|...........||. :.::.||:|.|  .||::|            |||             
 Frog  1346 EQPETAISVDAALLEESPVSVYLFPEEIKSGNKRQTT------------SPS------------- 1385

  Fly  1282 LQSYYHQSQVQPQTSLGSQVQQELG---SLGNASLEER-DFDIIHDEEISRMDKFG---VKQIYI 1339
                      .|..:.|...|:.||   :.|::.|.:. ||.|:....|....|.|   |:::. 
 Frog  1386 ----------PPPLTEGRVSQESLGLSDTSGDSELTDTDDFCILDAPGIGVPPKDGEPVVRKLV- 1439

  Fly  1340 SEDPLQIVDNHFELPHEKVDLLRPPSNFPVAESTYTLCEMTFTWHLYGGRDF----PDEPLKKSS 1400
             :.|:.:.|.||..|....|||:||:.|||.|:...|.|::..||||||:||    |:....:|.
 Frog  1440 -DSPIAVRDGHFSRPLGSTDLLKPPAKFPVPETRIVLREISVVWHLYGGKDFGSSRPNSARAQSP 1503

  Fly  1401 SSATSGFGMSDTYKYGVSQAQEQDKQDKKG--SKKGLLKQPK-------GSQRNLEVLVEMQLSK 1456
            .|.||                   ..:.:|  |:..:..:|:       |:.|..::|:|:||:|
 Frog  1504 RSRTS-------------------FHNARGSPSRSSVTNRPQNTWRTQGGNGRIHDILMEIQLTK 1549

  Fly  1457 IRFSYETYP--------------LTSMYSSRQVLLVSEIEIRDRLRSSDINKFLYHPTGNNLSHK 1507
            :.|.:|:||              |..:..:|||.:|.|:||||||.||.||||||..|...:..:
 Frog  1550 VSFQHESYPEPLADGEEKLHTGDLDELPLARQVFIVQELEIRDRLASSHINKFLYLYTSEKMPRR 1614

  Fly  1508 PDENMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNIDQDTLLFLEDFFSGMFRNSASAAGGTK 1572
            ...||:.:|||:|||. ......||.||:|::|::||||||.|.||:|||:       |.|.|.:
 Frog  1615 AHSNMLTIKALHVRPE-AGLGGPECYLRMSLMPLRLNIDQDALFFLKDFFT-------SLASGIQ 1671

  Fly  1573 T-----EGSSSSATDMPVMSVSKMPEELSDKLPDSEVKEMVERNLNVLIEENSLDVELEEDPATA 1632
            |     .||.:|..|.|..|.|           |.|:::...:.       ::.|..:....:|.
 Frog  1672 TIVPMELGSEASRLDGPAKSSS-----------DCELEQETSQG-------STEDETMSPSSSTD 1718

  Fly  1633 PPVFFREVIFSPALPICFDYHGRRIELSR-GPVTGLIMGLAQLQGSGINLREIVNRRGILGWNKL 1696
            .|::|||..|:..:||..||.|:.:...: |...|:::|||||..|.:.|:.:..|.|:||.:|:
 Frog  1719 QPIYFREFRFTSEVPIWLDYQGKHVTTEQVGTFAGILIGLAQLNCSELKLKRLYCRHGLLGADKV 1783

  Fly  1697 CEFLAKEWLKDIKRNQLPNILSGIGPTNAVLQLFQGIYDLFRLPIEQYNKDGRIIRGFQLGAQSF 1761
            ..:...|||.||::||||.||.|:||.::|:|||.|:.|||.||||||.||||||||.|.||.||
 Frog  1784 VSYALNEWLTDIRKNQLPGILGGVGPMHSVVQLFHGVRDLFWLPIEQYRKDGRIIRGLQRGAASF 1848

  Fly  1762 TARTALAALEITSRIIHLLQFTAETTFDMLSAGPSMKK-RKGGRQGKRRRQG-RPKDLREGVANA 1824
            ...||.||||:::|::..:|.||||.:|:||..|.:.: ....||.::.|:| :|.|||||||.|
 Frog  1849 GTSTASAALELSNRLVQAIQATAETVYDILSPTPPVSRCALDVRQSRKLRRGQQPADLREGVAKA 1913

  Fly  1825 YTIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSL 1889
            |..||||:.::|:|:.|.|...|:|||.:||||.|:||||..||.|.::||:||:|:|||.::.:
 Frog  1914 YDTVREGVIDTAHTICEVASRGHEQKGLTGAVGGVLRQIPPTVVKPFIVATEATSNLLGGMRNQI 1978

  Fly  1890 IPEAKLEARDKWKQE 1904
            .|:|..|...||:.:
 Frog  1979 RPDAHKEDALKWRAD 1993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg2NP_001261341.1 Chorein_N 17..117 CDD:289396 41/99 (41%)
ATG_C 1814..1902 CDD:286423 46/87 (53%)
atg2aNP_001072654.1 Chorein_N 19..108 CDD:372231 40/90 (44%)
MRS6 20..>240 CDD:227376 78/233 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..281 4/42 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1292..1323 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1371..1414 15/77 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1492..1534 8/60 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1684..1718 7/51 (14%)
ATG_C 1898..1991 CDD:370441 48/92 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 551 1.000 Domainoid score I249
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 743 1.000 Inparanoid score I584
OMA 1 1.010 - - QHG46464
OrthoDB 1 1.010 - - D18730at33208
OrthoFinder 1 1.000 - - FOG0002365
OrthoInspector 1 1.000 - - otm47641
Panther 1 1.100 - - LDO PTHR13190
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R107
SonicParanoid 1 1.000 - - X1792
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.110

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