DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg2 and atg2b

DIOPT Version :9

Sequence 1:	NP_001261341.1	Gene:	Atg2 / 38344	FlyBaseID:	FBgn0044452	Length:	1906	Species:	Drosophila melanogaster
Sequence 2:	XP_012824091.2	Gene:	atg2b / 780082	XenbaseID:	XB-GENE-5763717	Length:	2068	Species:	Xenopus tropicalis

Alignment Length:	2246	Identity:	628/2246 - (27%)
Similarity:	986/2246 - (43%)	Gaps:	528/2246 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PW---DGLKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLFEDQGWA 67
            ||   :.:|.:.||||||||||.|.:..|:||||.:|||.|...:..:.|...:.|::.|.....
Frog     2 PWPFSESIKKRACRYLLQRYLGHFLQEKLSLEQLTLDLYQGTGSLSQVPLDKWSLNEILESADAP 66

  Fly    68 FEVVSGHIGRLTVVVPWNALMTNDSSLEIHNLTITLRPVTRYQSGTTMLESM-WSS-VSSSMQMA 130
            .||..|.|..:::.:||.:|:.::.:||:..|.:..||..|.:||:   |.| ||| ::||||:|
Frog    67 LEVTEGFIQAISLSIPWGSLLQDNCALEVKGLEMVFRPRPRLRSGS---EPMYWSSFMTSSMQLA 128

  Fly   131 EECMKQVDDD-----VPFLNHNNALIGLEKFAETIDNVLNRIRAKLTNTTLNIEYILPRSDRKLV 190
            :||:.|...|     .||       .|||||||||:.||.|:|....:|...||.|...|.....
Frog   129 KECLSQKLTDEQEASQPF-------EGLEKFAETIETVLRRVRVTFIDTVFRIENIPENSKTGTA 186

  Fly   191 LSFQASHVEYKNKTGYE-----------------------------------MPMSTSQDTETEE 220
            |..:.|.:.|.::|..:                                   .|:.::...|.|.
Frog   187 LEIRISRIMYSDETADDHSGVNVHQPSAFAHKALELGGVSIFWDEFPASAKCSPVCSTSQVENEP 251

  Fly   221 DPNSSFNALPMIAKHNLVIEGLSLHTSEVLDVMDHQFGPTPYEQLCKIVELKGAQNIQINIKQTE 285
            ..:.|:|..|:...|       ...|..|.:|. |. ||.      :|..|.|...:.:.:||.|
Frog   252 KLSPSWNPKPVFEPH-------PQFTRNVPEVA-HS-GPV------QIATLLGKIELGLILKQKE 301

  Fly   286 NIVGPKVSLELSLDDIYFMLTPRQIHLLIEF--------SKGFNCGGQQERPKK----------- 331
            .::|.|:.::..:...:|.|:|||:|.|::.        |.|......:||..:
Frog   302 VLLGTKLDVDGRIGSFHFFLSPRQVHHLLDLVAAIAGPESSGRTPLSNKERRNRPMQQEDEFHIQ 366

  Fly   332 ---GRSLKSAP--------PSEYQMHSLQQP-TRMTGILGQNADWCTGMS-------------EA 371
               .|.::..|        .|.|:..:.:.| :....:....||..|..|             :.
Frog   367 MELNRYIRKEPVPGGVSSEHSFYESDTAKTPSSHDEEVFFSMADMDTSHSLSTLPPLGDPNTVDL 431

  Fly   372 DPSEYSVYGNPPRSG-------------YARSRKMSE-------------STNSMVTSCTNTLQQ 410
            |.|..|.|.|.|...             |....|:.|             ..||:  ..|:...:
Frog   432 DLSLPSTYTNTPAGSPLGPTMLQHAWGDYHEHHKLEEHLMRGTSFRHPIVHPNSL--RRTSLPSR 494

  Fly   411 ELGYTEKSGEILKFKVQISKIYGIALHQDILIQNTANIDSCSTV----------FDHASYLRYSD 465
            .:...|...|:: |::.|..:....||.|.|.....|    ||.          |.|...|
Frog   495 SVSMDESRPELV-FRLAIGSLSVSVLHIDPLPPTETN----STTNPLTPMSHDFFSHIEKL---- 550

  Fly   466 TASGFFLGTLLENHIPLQNQQYLLLR-----AAP---IIVSGSQQRYFQELTSRTTLSATAVD-- 520
                        :.|......:|..|     |.|   :...|:..:...|...|:.|.:.:.|
Frog   551 ------------DPITFPKDDFLCFRNIFADACPYDHLRFIGTDIKISHEQRQRSGLRSFSTDVC 603

  Fly   521 -----LIEVL---DNSK-----EHLLQFD-------RQRNCPDGYHIRPEIVLTQSSSFMFKQNH 565
                 |:|.|   |:..     ..||:||       |...|...|:...|....|.||.......
Frog   604 IGYTELLECLFPTDSQSVPPQYTELLRFDCDKTGETRTSPCIHLYYKHSENRGPQGSSGRLNSAP 668

  Fly   566 NRCSNKIECSLDECTAELDISIYDRLGALFGSSP------------------FSGDSASSTPYPD 612
            .|...:|:.|...|  ||||||.|||.:|..:..                  .|...|.:..:.|
Frog   669 RRSELQIKLSPSSC--ELDISIVDRLNSLLQAQKMGTVEMMTSHLYTSYNKHISLHKAFAEVFLD 731

  Fly   613 D---PNQT--EFVVKSENLRLHLRFPVVDGRAANDPLKIPWWKKNVRRD-----FLAVEFRSLV- 666
            |   |..|  ..:|.:..|.|.:|||:.|.|  :|..:.||:||:::::     |..|||::.:
Frog   732 DSGSPANTRVSVMVSAPVLNLAVRFPIPDLR--SDQERGPWFKKSLQKEILHLKFSDVEFKTEIF 794

  Fly   667 ---VSSRSQISIVSDELD-VFYCDADKQS--------------------------------AVH- 694
               ...:.::.:...||. .|..|:||..                                |||
Frog   795 DGSTPEQMKLELTFKELSGAFQEDSDKPQINFFRVCSTLDGDITSSDNFDWPRIVLKINPVAVHS 859

  Fly   695 ---LLKCQQKMQPNKKIQID----VLQLKDTSDGQKKARKSPFSSKCTFGYTSHVEGLDGSVDKT 752
               .:..::..:.:.:.|.|    ...|||..| .::...|||||:...            .:..
Frog   860 ILERIAAEEDDEADGRFQEDDEGASHSLKDVCD-LRRPEPSPFSSRRVM------------FENE 911

  Fly   753 DSLLPGETEEINEFCDSCTQSSKLKIFAFIPHVKVVLESKSMYELIYNRLNGDLFMWEPRSP--- 814
            :.::||:..|:.||.:....:|...:...:|.|.:.|.:|:.||.:|||::.||.:|||.:|
Frog   912 EMVMPGDAIEMTEFQEKAISNSHYILELTLPSVYMTLPNKAFYEKLYNRVSNDLLLWEPTAPSPV 976

  Fly   815 ------HYDI------------SPDNEVPESKDLYAEPQLEEFRRNLLLSTSAMESSIYFSMAEP 861
                  .|.|            |.|........||.:....|  ...:.....|:|:.:....:.
Frog   977 ETFENLSYGIGLSVASQLITNFSKDGCNQYKSGLYEDDSGSE--EETMQHDYIMDSNYHCRRKKK 1039

  Fly   862 TASAPPAPPVRNEAF-SFELFVEQGTLILFSHLLDPETNQRSKECGKFQVNLKELRLFTVNGLDN 925
            :.|...    ::::| |..:.:..|.:.|||.:..|:...:..:.|:|.:......||:|...:.
Frog  1040 SESLNK----QSQSFLSVLVNINHGLVSLFSDVKQPDGVVKENQHGEFWLEFHSGSLFSVAKYEG 1100

  Fly   926 DSTRSFFSIQLGEIDALHCGNTLQDLELAWSDLADEKLL----------PTIY------------ 968
            ...:.:..:....:...|.|  |.|..:.    :||..|          ||||
Frog  1101 FEDKHYVCLHSSSLSLYHQG--LLDGGIP----SDEIRLPSMTRPHWLEPTIYSSEEDGIYSLPA 1159

  Fly   969 -NFASVHQQQDRKRMEVLSLVAEIKK-QPEQRIKRMKMSFGICGAILQHHSCHSEHSWLNQLIDF 1031
             |...|..|      .:|::..:|:. :.|...|...::.|:.||.|||....||.:|..|::.|
Frog  1160 SNGVGVESQ------SMLTVAVKIQSDKSESNTKEFLVAIGLRGATLQHRVLPSEVTWHEQVLQF 1218

  Fly  1032 MDVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQRAFLDLGYCTLSSNIISSMSGCTLRLL 1096
            :::.|.|:..|.|.|.::...:|:|:..:|:||.:.|.||.|.:...::|.::....|..:||::
Frog  1219 LNILDEPVLGYNPPASITTFHVHLWSCALDHRPLYLPTRALLTVETFSISCSVALDKSSSSLRII 1283

  Fly  1097 AEDCVLQL----GLVKEESNDSLIPVLNLGLLNISFRLNAEG-SGQPRVDLRSSIHDMHLKTCYD 1156
            .|:..|.|    ..|....|...:.||::|||.::......| ..:||.::..|...:|::||.|
Frog  1284 MEEAALHLSDKCNAVAVNLNRDYVRVLDMGLLELTILSVKTGEKSKPRFEMHCSSDVIHIRTCSD 1348

  Fly  1157 SAAALAQLIAYVANDRDLCPPEEPILNEDTKPAEPKPNEEHE-----------MSDHTQNHVSKL 1210
            |.|||..||.|:|:..||.||.    ..:|.|...|.|:..:           :::..|..:..|
Frog  1349 SCAALMNLIQYLASYGDLHPPS----RTETSPGAHKKNKTTDPVTQANIQGPVLAEAEQQILRDL 1409

  Fly  1211 MADAVIDVE-------SSPNLRAMKSPGGREEGIE-----IFYFPDEPKEKRKSTSAKL--QTKS 1261
            |:||:.|.:       |.|:|..:..  ||.|..|     :|.||||.....:.:|...  .|..
Frog  1410 MSDAMEDTDLNHIVCPSKPHLNGISE--GRCETQEPPCSDLFLFPDESGNVSEESSPMFPPTTPH 1472

  Fly  1262 LMVESPSVIGDILDFESNVILQSYYHQSQVQPQTSLGSQVQQELGSLGNASLEERDFDIIH---- 1322
            |:.|:      :|||.|                                   |..||.|::
Frog  1473 LLSEA------MLDFPS-----------------------------------ESDDFCILYAPKN 1496

  Fly  1323 -----DEEISRMDKFGVKQIYISEDPLQIVDNHFELPHEKVDLLRPPSNFPVAESTYTLCEMTFT 1382
                 |||.|      ||::.  :|.:.|.:|||.||.:|:|..:.|.:|||....|.:.|::..
Frog  1497 SVSEKDEEPS------VKKLV--DDNILIKENHFNLPLQKMDTSKAPLHFPVPVVRYVVKEVSLV 1553

  Fly  1383 WHLYGGRDF-----PDEPLKKSSSSATSGFGMSDTYKYGVSQAQEQDKQDKKGSKKGLLKQPKGS 1442
            ||||||:||     |..|.|...|..:|                ..:...::|:  .|::..:|
Frog  1554 WHLYGGKDFGSALPPLSPAKHYISPHSS----------------PSNTPTRRGN--SLVRGGRG- 1599

  Fly  1443 QRNLEVLVEMQLSKIRFSYETYP-------LTSMYS--SRQVLLVSEIEIRDRLRSSDINKFLYH 1498
             ||.::|:|:|.||::|.:|.||       ..||..  ||||.:|.::||||||.||.:||||:.
Frog  1600 -RNQDLLMEIQFSKVKFQHEVYPQGASTVESPSMEQPVSRQVFIVQDLEIRDRLASSQMNKFLHL 1663

  Fly  1499 PTGNNLSHKPDENMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNIDQDTLLFLEDFFSGMFRN 1563
            .:...:..|...||:.:|||:|||...: |.:||.|||:::|::||||||.|.||:|||:.:
Frog  1664 YSSKEMPRKAHSNMLTIKALHVRPETGQ-SPQECCLRVTLMPLRLNIDQDALFFLKDFFTNL--- 1724

  Fly  1564 SASAAGGTKTEGSSSSATDMPVMSVSKMPEELSDKLPDSEV-----KEMVERNLNVLI------- 1616
                            :|::.:: |:..||  ..:.|.|:|     |.:..:..|.:|
Frog  1725 ----------------STEVEIL-VTPDPE--VKRYPASDVTCSLPKHLYSQERNPVISFIGQSE 1770

  Fly  1617 -EEN-SLDVE-----LEEDPATAPPVFFREVIFSPALPICFDYHGRRIELSRGPVTGLIMGLAQL 1674
             |:| |::.|     ..|:..:..||||||..|:..:||..||||:.:.:.:|.:||:::|||||
Frog  1771 PEKNGSINSEHIAQSASEEAFSDQPVFFREFRFTSEVPIRLDYHGKHLSMDQGTLTGILIGLAQL 1835

  Fly  1675 QGSGINLREIVNRRGILGWNKLCEFLAKEWLKDIKRNQLPNILSGIGPTNAVLQLFQGIYDLFRL 1739
            ..|.:.|:.:..|.|:||.:||..:...|||.|||:.|||.||.|:||.::::||.||:.||..|
Frog  1836 NNSELKLKRLCYRHGLLGLDKLFSYAVNEWLTDIKKTQLPGILGGVGPMHSLVQLVQGLKDLVWL 1900

  Fly  1740 PIEQYNKDGRIIRGFQLGAQSFTARTALAALEITSRIIHLLQFTAETTFDMLSAGPS-MKKRKGG 1803
            |||||.|||||:||||.||.||...||:||||:|:||:..:|..|||.:||:|.||| ::.::..
Frog  1901 PIEQYRKDGRIVRGFQKGAASFGTSTAMAALELTNRIVQTIQAAAETAYDMVSPGPSPVELKRAK 1965

  Fly  1804 RQGKRRRQGRPKDLREGVANAYTIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVV 1868
            |....|...:|.|||||||.|||:|:|||.::|.|:.|.|..||:.:|.:||||.|:||||..||
Frog  1966 RFSHHRLVHQPVDLREGVAKAYTVVKEGITDTAQTIYETAAREHENRGVTGAVGGVLRQIPPAVV 2030

  Fly  1869 CPAVLATQATTNILGGAKSSLIPEAKLEARDKWKQE 1904
            .|.::||:||:|:|||.::.:.|:.:.|...||:.|
Frog  2031 KPLIVATEATSNVLGGMRNQIRPDVREEESQKWRLE 2066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg2	NP_001261341.1	Chorein_N	17..117	CDD:289396	36/99 (36%)
Atg2	NP_001261341.1	ATG_C	1814..1902	CDD:286423	45/87 (52%)
atg2b	XP_012824091.2	Chorein_N	16..>105	CDD:403729	32/88 (36%)
		MRS6	17..>233	CDD:227376	73/225 (32%)
		MRS6	<1785..2051	CDD:227376	132/265 (50%)
		ATG_C	1974..2064	CDD:401321	45/89 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	551	1.000	Domainoid score	I249
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9974
Inparanoid	1	1.050	743	1.000	Inparanoid score	I584
OMA	1	1.010	-	-		QHG46464
OrthoDB	1	1.010	-	-		D18730at33208
OrthoFinder	1	1.000	-	-		FOG0002365
OrthoInspector	1	1.000	-	-		otm47641
Panther	1	1.100	-	-	O	PTHR13190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R107
SonicParanoid	1	1.000	-	-		X1792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110