DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg2 and ATG2B

DIOPT Version :9

Sequence 1:	NP_001261341.1	Gene:	Atg2 / 38344	FlyBaseID:	FBgn0044452	Length:	1906	Species:	Drosophila melanogaster
Sequence 2:	NP_060506.6	Gene:	ATG2B / 55102	HGNCID:	20187	Length:	2078	Species:	Homo sapiens

Alignment Length:	2266	Identity:	609/2266 - (26%)
Similarity:	974/2266 - (42%)	Gaps:	562/2266 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PW---DGLKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLFEDQGWA 67
            ||   :.:|.:.||||||||||.|.:..|:||||.:|||.|...:..:.|.....|::.|.....
Human     2 PWPFSESIKKRACRYLLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESADAP 66

  Fly    68 FEVVSGHIGRLTVVVPWNALMTNDSSLEIHNLTITLRPVTRYQSGTTMLESM-WSS-VSSSMQMA 130
            .||..|.|..:::.|||.:|:.::.:||:..|.:..||..|..:|:   |.| ||| ::||||:|
Human    67 LEVTEGFIQSISLSVPWGSLLQDNCALEVRGLEMVFRPRPRPATGS---EPMYWSSFMTSSMQLA 128

  Fly   131 EECM------KQVDDDVPFLNHNNALIGLEKFAETIDNVLNRIRAKLTNTTLNIEYILPRSDRKL 189
            :||:      :|.:...||       .|||||||||:.||.|::....:|.|.||
Human   129 KECLSQKLTDEQGEGSQPF-------EGLEKFAETIETVLRRVKVTFIDTVLRIE---------- 176

  Fly   190 VLSFQASHVEYKNKTGYEMPMSTSQDTETEE--DPNSSFNA-LPMIAKHNLV-IEGLSL------ 244
                   ||...:|||..:.:...:....:|  |.:|..|. .|....|.|: :.|:||
Human   177 -------HVPENSKTGTALEIRIERTVYCDETADESSGINVHQPTAFAHKLLQLSGVSLFWDEFS 234

  Fly   245 ---HTSEVLDVMDHQFGP------------TPYEQLCK------------IVELKGAQNIQINIK 282
               .:|.|......:..|            .|:.||.:            |..|.|...:.:.:|
Human   235 ASAKSSPVCSTAPVETEPKLSPSWNPKIIYEPHPQLTRNLPEIAPSDPVQIGRLIGRLELSLTLK 299

  Fly   283 QTENIVGPKVSLELSLDDIYFMLTPRQIHLLIEFSKGF----NCG--GQQERPKKGRSLKSAPPS 341
            |.|.:.|.|:.::..:|.|:.:|:|||:|||::.....    |..  |...:.:|.|.::.....
Human   300 QNEVLPGAKLDVDGQIDSIHLLLSPRQVHLLLDMLAAIAGPENSSKIGLANKDRKNRPMQQEDEY 364

  Fly   342 EYQM----HSLQQPTRMTGILGQNADWCT---------------GMSEADPSEYSVYGNPPRSGY 387
            ..||    :.|::.:...|:..:.:.:.|               .|::.|.| :|:...||
Human   365 RIQMELNRYYLRKDSLSVGVSSEQSFYETETARTPSSREEEVFFSMADMDMS-HSLSSLPP---- 424

  Fly   388 ARSRKMSESTN-----SMVTSCTNT----------LQQELG------------------------ 413
                 :.:..|     |:.::.|||          ||...|
Human   425 -----LGDPPNMDLELSLTSTYTNTPAGSPLSATVLQPTWGEFLDHHKEQPVRGSTFPSNLVHPT 484

  Fly   414 ------------YTEKSGEILKFKVQISKIYGIALHQDIL-----IQN----------------- 444
                        ..::|...|.|::.:.......||.|.|     .||
Human   485 PLQKTSLPSRSVSVDESRPELIFRLAVGTFSISVLHIDPLSPPETSQNLNPLTPMAVAFFTCIEK 549

  Fly   445 -------TANIDSCSTVFDHA---SYLRYSDTASGFFLGTLLENHIPLQNQQYLLLRAAPIIVSG 499
                   |.:..|...||..|   .:||        |:||.::  :..:.:|            .
Human   550 IDPARFSTEDFKSFRAVFAEACSHDHLR--------FIGTGIK--VSYEQRQ------------R 592

  Fly   500 SQQRYFQELTSRTTLSATAVDLIEVLDNSKEHLLQFDRQRNCPDGY------HIRPEIVLTQSSS 558
            |..|||.     |.:|...::.:|.|..:..|        :.|..|      |.:.|   |.|.|
Human   593 SASRYFS-----TDMSIGQMEFLECLFPTDFH--------SVPPHYTELLTFHSKEE---TGSHS 641

  Fly   559 -----FMFKQNHNRCSN-------------KIECSLDECTAELDISIYDRLGALFG--------- 596
                 ..:|.:.||...             :::..|:....||||||.|||.:|..
Human   642 PVCLQLHYKHSENRGPQGNQARLSSVPHKAELQIKLNPVCCELDISIVDRLNSLLQPQKLATVEM 706

  Fly   597 ---------SSPFSGDSASSTPYPDDPN-----QTEFVVKSENLRLHLRFPVVDGRAANDPLKIP 647
                     :...|...|.:..:.||.:     :....|.:..|.|.:|||:.|.|  :|..:.|
Human   707 MASHMYTSYNKHISLHKAFTEVFLDDSHSPANCRISVQVATPALNLSVRFPIPDLR--SDQERGP 769

  Fly   648 WWKKNVRRD-----FLAVEFRS------------LVVSSRSQISIVSDE-----LDVFY----CD 686
            |:||:::::     |..:||::            |.::.|..|....:|     :..|:    .|
Human   770 WFKKSLQKEILYLAFTDLEFKTEFIGGSTPEQIKLELTFRELIGSFQEEKGDPSIKFFHVSSGVD 834

  Fly   687 ADKQS----------------AVH----LLKCQQKMQPNKKIQID----VLQLKDTSDGQKKARK 727
            .|..|                |:|    .:..:::.:.:...|.:    ...|||..|.::.| .
Human   835 GDTTSSDDFDWPRIVLKINPPAMHSILERIAAEEEEENDGHYQEEEEGGAHSLKDVCDLRRPA-P 898

  Fly   728 SPFSSKCTFGYTSHVEGLDGSVDKTDSLLPGETEEINEFCDSCTQSSKLKIFAFIPHVKVVLESK 792
            |||||:...            .:....::||:..|:.||.|....:|...:...:|::.|.|.:|
Human   899 SPFSSRRVM------------FENEQMVMPGDPVEMTEFQDKAISNSHYVLELTLPNIYVTLPNK 951

  Fly   793 SMYELIYNRLNGDLFMWEPRSPHYDISPDNEVPESKDLYAEPQL-EEFRRNLLLSTSAMESSI-- 854
            |.||.:|||:..||.:|||.:|. .:.....:.....|....|| ..|.::   |.||.:|::
Human   952 SFYEKLYNRIFNDLLLWEPTAPS-PVETFENISYGIGLSVASQLINTFNKD---SFSAFKSAVHY 1012

  Fly   855 ------------YFSMAEPTASAPPAPPV-----RNEAF-SFELFVEQGTLILFSHLLDPETNQR 901
                        |||..:|...:.....:     .:::| |..|.:..|.:.:|:.:.....:..
Human  1013 DEESGSEEETLQYFSTVDPNYRSRRKKKLDSQNKNSQSFLSVLLNINHGLIAVFTDVKQDNGDLL 1077

  Fly   902 SKECGKFQVNLKELRLFTVNGLDNDSTRSFFSIQLGEIDALHCG---NTLQDLELAW-SDLADEK 962
            ..:.|:|.:......||.|...:....:.:..:........|.|   ..:...|... |......
Human  1078 ENKHGEFWLEFNSGSLFCVTKYEGFDDKHYICLHSSSFSLYHKGIVNGVILPTETRLPSSTRPHW 1142

  Fly   963 LLPTIYNFASVHQQQD-----------RKRMEVLSLVAEI-KKQPEQRIKRMKMSFGICGAILQH 1015
            |.||||:     .::|           ...:.:||:..:| ..:.|...|...::.|:.||.|||
Human  1143 LEPTIYS-----SEEDGLSKTSSDGVGGDSLNMLSVAVKILSDKSESNTKEFLIAVGLKGATLQH 1202

  Fly  1016 HSCHSEHSWLNQLIDFMDVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQRAFLDLGYCTL 1080
            ....|..||..|::.|:::||.|:..|.|....:...:|:|:..:||||.:.|.|:.|.:...::
Human  1203 RMLPSGLSWHEQILYFLNIADEPVLGYNPPTSFTTFHVHLWSCALDYRPLYLPIRSLLTVETFSV 1267

  Fly  1081 SSNIISSMSGCTLRLLAEDCVLQL----GLVKEESNDSLIPVLNLGLLNISF-RLNAEGSG---Q 1137
            ||::....|..|||::.::..|.|    ..|....:...:.|:::|||.::. .:.::..|   :
Human  1268 SSSVALDKSSSTLRIILDEAALHLSDKCNTVTINLSRDYVRVMDMGLLELTITAVKSDSDGEQTE 1332

  Fly  1138 PRVDLRSSIHDMHLKTCYDSAAALAQLIAYVANDRDLCPPEEPILNEDTKPAEPKPNEEHEMSDH 1202
            ||.:|..|...:|::||.||.|||..||.|:|:..||..|.:    .|.||...:...:.:.|..
Human  1333 PRFELHCSSDVVHIRTCSDSCAALMNLIQYIASYGDLQTPNK----ADMKPGAFQRRSKVDSSGR 1393

  Fly  1203 T-----------QNHVSKLMADAVIDVESSPNLRAMKSPGGREEGI-------------EIFYFP 1243
            :           |..:..||:||:.:::......::|.   :..|:             ::|.||
Human  1394 SSSRGPVLPEADQQMLRDLMSDAMEEIDMQQGTSSVKP---QANGVLDEKSQIQEPCCSDLFLFP 1455

  Fly  1244 DEPKEKRKSTSAKLQTKSLMVESPSVIGDILDFESNVILQSYYHQSQVQPQTSLGSQVQQELGSL 1308
            ||.                        |::.. ||.....|:.|.......|.:.:
Human  1456 DES------------------------GNVSQ-ESGPTYASFSHHFISDAMTGVPT--------- 1486

  Fly  1309 GNASLEERDFDIIHDEEISRMDKFGVKQIYIS-EDPLQIVDNHFELPHEKVDLLRPPSNFPVAES 1372
                 |..||.|:...:.:..:|.....|.|. :|.:.|.||:|.||..|.|..:.|.:||:...
Human  1487 -----ENDDFCILFAPKAAMQEKEEEPVIKIMVDDAIVIRDNYFSLPVNKTDTSKAPLHFPIPVI 1546

  Fly  1373 TYTLCEMTFTWHLYGGRDF----PDEPLKK-----SSSSATSGFGMSDTYKYGVSQAQEQDKQDK 1428
            .|.:.|::..||||||:||    |..|.|.     ||.|.|.
Human  1547 RYVVKEVSLVWHLYGGKDFGIVPPTSPAKSYISPHSSPSHTP----------------------- 1588

  Fly  1429 KGSKKGLLKQPKGSQRNLEVLVEMQLSKIRFSYETYP---------LTSMYSSRQVLLVSEIEIR 1484
              ::.|......|..||.:.|:|:||||::|.:|.||         |:....||||.:|.::|||
Human  1589 --TRHGRNTVCGGKGRNHDFLMEIQLSKVKFQHEVYPPCKPDCDSSLSEHPVSRQVFIVQDLEIR 1651

  Fly  1485 DRLRSSDINKFLYHPTGNNLSHKPDENMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNIDQDT 1549
            |||.:|.:|||||......:..|...||:.||||:|.|...: |.:||.||||::|::||||||.
Human  1652 DRLATSQMNKFLYLYCSKEMPRKAHSNMLTVKALHVCPESGR-SPQECCLRVSLMPLRLNIDQDA 1715

  Fly  1550 LLFLEDFFSGMFRNSASAAGGTKTEGSSSSATDMPVMSVSKMPEELSDKLPDSEVKEMVERNL-- 1612
            |.||:|||:     |.||.                 :.:...|:....|.|.::|...:.|:|
Human  1716 LFFLKDFFT-----SLSAE-----------------VELQMTPDPEVKKSPGADVTCSLPRHLST 1758

  Fly  1613 ----NVLI------------EENSLDV---------ELEEDPATAPPVFFREVIFSPALPICFDY 1652
                |::|            ..||::|         ..||......||||||..|:..:||..||
Human  1759 SKEPNLVISFSGPKQPSQNDSANSVEVVNGMEEKNFSAEEASFRDQPVFFREFRFTSEVPIRLDY 1823

  Fly  1653 HGRRIELSRGPVTGLIMGLAQLQGSGINLREIVNRRGILGWNKLCEFLAKEWLKDIKRNQLPNIL 1717
            ||:.:.:.:|.:.|:::|||||..|.:.|:.:..|.|:||.:||..:...|||.|||:||||.||
Human  1824 HGKHVSMDQGTLAGILIGLAQLNCSELKLKRLSYRHGLLGVDKLFSYAITEWLNDIKKNQLPGIL 1888

  Fly  1718 SGIGPTNAVLQLFQGIYDLFRLPIEQYNKDGRIIRGFQLGAQSFTARTALAALEITSRIIHLLQF 1782
            .|:||.::::||.||:.||..||||||.|||||:||||.||.||...||:||||:|:|::..:|.
Human  1889 GGVGPMHSLVQLVQGLKDLVWLPIEQYRKDGRIVRGFQRGAASFGTSTAMAALELTNRMVQTIQA 1953

  Fly  1783 TAETTFDMLSAGP-SMKKRKGGRQGKRRRQGRPKDLREGVANAYTIVREGINESANTLIEAAITE 1846
            .|||.:||:|.|. |::.:|..|....|...:|.|||||||.||::|:|||.::|.|:.|.|..|
Human  1954 AAETAYDMVSPGTLSIEPKKTKRFPHHRLAHQPVDLREGVAKAYSVVKEGITDTAQTIYETAARE 2018

  Fly  1847 HDQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEAKLEARDKWK 1902
            |:.:|.:||||.|:||||..||.|.::||:||:|:|||.::.:.|:.:.:...||:
Human  2019 HESRGVTGAVGEVLRQIPPAVVKPLIVATEATSNVLGGMRNQIRPDVRQDESQKWR 2074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg2	NP_001261341.1	Chorein_N	17..117	CDD:289396	36/99 (36%)
Atg2	NP_001261341.1	ATG_C	1814..1902	CDD:286423	43/87 (49%)
ATG2B	NP_060506.6	Chorein_N	11..106	CDD:315323	36/94 (38%)
		VPS13	17..>234	CDD:330393	81/243 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..495		0/21 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	868..888		1/19 (5%)
		ATG2_CAD	1245..1372	CDD:315899	39/126 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1375..1405		4/29 (14%)
		ATG_C	1980..2074	CDD:312735	44/93 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146019
Domainoid	1	1.000	528	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2993
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9974
Inparanoid	1	1.050	711	1.000	Inparanoid score	I650
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46464
OrthoDB	1	1.010	-	-		D18730at33208
OrthoFinder	1	1.000	-	-		FOG0002365
OrthoInspector	1	1.000	-	-		otm40464
orthoMCL	1	0.900	-	-		OOG6_102791
Panther	1	1.100	-	-	O	PTHR13190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R107
SonicParanoid	1	1.000	-	-		X1792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800