Protein Alignment Atg2 and atg2

DIOPT Version :9

• Sequence 1: NP_001261341.1
• Gene: Atg2 / 38344
• FlyBaseID: FBgn0044452
• Length: 1906
• Species: Drosophila melanogaster
• Sequence 2: NP_001342784.1
• Gene: atg2 / 3361214
• PomBaseID: SPBC31E1.01c
• Length: 1646
• Species: Schizosaccharomyces pombe
• Alignment Length: 2093
• Identity: 389/2093 - (18%)
• Similarity: 710/2093 - (33%)
• Gaps: 651/2093 - (31%)

  Fly     2 SWFNPWDG-----LKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLF 61
            ||.  |..     ::.::..:.|::.:|.....|:..|.:.:....|..::.::.|..:..|
pombe    12 SWL--WTAALSRTVQRRLLAFALRKLIGSILLENVQPEDIDILFSKGVLMLSNLQLNCSFLN--- 71

  Fly    62 EDQGWAFEVVS--------GHIGRLTVVVPWNALMTNDSSLEIHNLT--ITLRPVTRYQSGTTML 116
                   .|||        |.:.||.:.:....::..:..||::.|:  |.|.|.....|.||.
pombe    72 -------AVVSLPMINFTKGTLRRLILRLNVTDIVNLNVELEVNGLSLEIELVPPDESLSSTTY- 128

  Fly   117 ESMWSSVSSSMQMAEECMKQVDDDVPFLNHNNALIGLEKFAETIDNVLNRIRAKLTNTTLNIEYI 181
                          |:...|:|                    .:|||
pombe   129 --------------EDAPSQLD--------------------ILDNV------------------ 141

  Fly   182 LPRSDRKLVLSFQASHVEYKNKTGYEMPMSTSQDTETE--------EDPNSSFNALPMIAKHNLV 238
                            |||.|||       .|||.|.|        |...||.|.|..|.:..|.
pombe   142 ----------------VEYMNKT-------ASQDFEDEVINEGLESEIDGSSHNLLDSILQKCLA 183

  Fly   239 IEGLSLHTSEVLDVMDHQFGPTPYEQLCKIVELKGAQNIQINIKQTENIVGPKVSLELSLDDIYF 303
                  .||.::.           :.|..|    |..|:             ...||..||   |
pombe   184 ------STSVLMQ-----------DALVYI----GTANM-------------STRLEAKLD---F 211

  Fly   304 MLTPRQIHLLIEFSKGFNCGGQQERPKKGRSLKSAPPSEYQMHSLQQPTRMTGILGQNADWCTGM 368
            |          .||                |:||           ...:|:..|.|........:
pombe   212 M----------SFS----------------SVKS-----------NSTSRLLNINGITVSMVRPI 239

  Fly   369 SEADPSEYSVYGNPPRSGYARSRKMSESTNSMVTSCTNTLQ-QELGYTEKSGEILKFKVQISKIY 432
            |:::....|    ||||  ..|....:|::|:|....|.|. .::...|.|  |:....:....|
pombe   240 SKSNAGSSS----PPRS--EESFVSMDSSSSIVEGFENDLSPSQVTLNESS--IISSNREEESFY 296

  Fly   433 GIALHQDILIQNTAN---IDSCSTVFDHASYLRYSDTASGFFLGTLLENHIP-----LQNQQYLL 489
            .:  |..:..:.|..   |..||..|    .|.:|..:|...   ::|:|:|     :.:|....
pombe   297 SV--HDSVTQKKTRTSWLIFQCSGEF----RLVFSIESSNLL---VIESHVPSCVLNINSQVIAF 352

  Fly   490 LRAAPIIVSGSQQRYFQELTSRTTLSATAVDLIEVLDNSKEHLLQFDRQRNCPDGYHIRPEIVLT 554
            |    :.:.|    ||....|....|:....|.         :||.|        .||....:||
pombe   353 L----LYLYG----YFLPAPSTPGFSSNKPPLT---------MLQLD--------IHISSVQILT 392

  Fly   555 QSSSFMFKQNHNRCSNKIECSLDECTAELDISIYDRLGALFGSSPFSGDSASSTPYPDDPNQTEF 619
                              .|.|.|   ..|.|:::.:..|..:.|.:|     ..:....||.:.
pombe   393 ------------------HCKLPE---SQDFSMHNDVDELLHTIPSNG-----AVFEMKINQIQI 431

  Fly   620 VVKSENL-RLHLRFPVVD-----------GRAANDPLKIPWWKK--------NVRRDFLAVEFRS 664
            ...:.:: .|.:.|..:|           |::...|..:.:.|.        ::....:::....
pombe   432 FNDNNDIDELTMTFSDLDIFMDSVTLVSFGKSLQSPCSLIFKKLERIVSLFIHIPGGEISLPLGK 496

  Fly   665 LVVSSRSQISIVSD--ELDVFYCDAD--KQSAVHLLKCQQKM-----QPNKKI--QIDVLQLKDT 718
            .::...|.:...:|  .|..|..::|  |:|.....:..:..     ||:.:|  ..|.|||:..
pombe   497 ALLLQESFVEFTNDISNLQNFLSNSDPFKRSIQETFEAPKPFEVEMNQPSFEIIALFDELQLQIL 561

  Fly   719 SDGQKKARKSPFSSKCTFGYTSHVEGLDGSVDKTDSLLPGETEEINEFCDSCTQSSKLKIFAFIP 783
            ::         .|::..:..|..|..|..:...|.||                  |.:.||.
pombe   562 NE---------LSTQSLYKLTLRVSHLQFTRKSTGSL------------------SSVLIFV--- 596

  Fly   784 HVKVVLESKSMYELIYNRLNGDLFMWEPRSPHYDISPDNEVPESKDLYAEPQLEEFRRNLLLSTS 848
             .|:..:|:     ::|..|.|   |...|........|.:.|:.|......         .:.|
pombe   597 -KKIGCQSE-----LFNCENSD---WTKVSSSTAFHLSNSLFETHDTTGTSN---------FAVS 643

  Fly   849 AMESSIYFSMAEPTASAPP--APPVRNEAF---SFELFVEQGTLILF--------SHLLDPETNQ 900
            ..:...|:.:.:|   ||.  :.|.::..|   :|.:|:.:..:.||        |.|:.|.|..
pombe   644 IQQEKHYYPVFQP---APTEFSYPEKHFYFAVDNFNVFISKEVVRLFKTLYETIASSLVTPVTPN 705

  Fly   901 RSKECGKFQVNLKELRLFTVNGLDNDSTRSFFSIQLGEIDALHCGNTLQDLELAWSDLADEKLLP 965
            :........|.....|.|:::.|::|.  |.|:::...|....|          |:......|..
pombe   706 KLVTSDYKNVLKIRTRTFSLSLLNDDG--SSFALKCIRIKHYMC----------WAGAQLISLSL 758

  Fly   966 TIYNFASVHQQQDRKRMEVLSLVAEIKKQPEQRIK-----RMKMSFG---------ICGAILQHH 1016
            .:||.::.:..:..:.:.|:|.:..::...:..:.     .:|.|.|         |.....:|:
pombe   759 RLYNVSAEYLSESLEILPVVSFIRNLRNDEKYLLNADFSYALKRSSGSNDNTIFVKITDLGYEHY 823

  Fly  1017 -SCHSEHSWLNQL----------IDFMDVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQR 1070
             :|    .|::.|          :.|:...|||.          .::|.:..:.|...|:....:
pombe   824 PTC----PWISDLLKTYFPQDPEVPFLAFPDFPF----------NIKLDLRESIIGLNPRTLEAK 874

  Fly  1071 AFLDLGYCTLSSNIISSMSGCTLRLLAEDCVLQL--------------GLVKEESNDSL------ 1115
            ..|.|....:..:.:.:.:...:|::|.:.|:.:              .|.:|..|.||
pombe   875 LLLYLKSLDVEIDALVASNPLNIRIMAAETVVYIIDKLNQSVLEGKTSVLKREILNSSLHFPGLS 939

  Fly  1116 --------------IPVLNLGLLNISFRLNAEGSGQPRVDLRSSIHDMHLKTCYDSAAALAQLIA 1166
                          :.:..|..|.:|..:||| .|.....:.....|..:::|.||...|.::::
pombe   940 IKDTIEFVVKSLGYVEISQLKNLTLSLVVNAE-EGVFSTLITVDNLDAQVQSCADSTELLIKVLS 1003

  Fly  1167 YVANDRDLCPPEEPILNEDTKPAEPKPNEEHEMSDHTQNHVSKLMADAVIDVESSPNLRAMKSPG 1231
            .:.:..|     |.|  .|...|.|..:....:::...|    ...:..||.:|:|.
pombe  1004 DLGSTED-----EEI--SDCYLALPIEDYAKSLTEVDYN----FFENRGIDYKSNPT-------- 1049

  Fly  1232 GREEGIEIFYFPDEPKEKRKSTSAKLQTKSLMVESPSVIGDILDFESNVILQSYY-----HQSQV 1291
                                      :..:::|.|.:   ||...|..:: ..||     |.:..
pombe  1050 --------------------------EQSTVLVSSDN---DISSQEIKIV-DDYYISSNEHSTHA 1084

  Fly  1292 QPQTSLGSQVQQELGSLGNASLEERDFDIIHDEEISRMD-KFGVKQI---YISEDPLQIVDNHFE 1352
            ....|:.|  ::.:...|::|:.:.. |.:.||..||.. |.|::.|   |:|:...::..:
pombe  1085 SDLASVSS--EEFVIDDGSSSIIDIS-DELQDESSSRDSLKKGIELIEDYYLSQSTSKLESS--- 1143

  Fly  1353 LPHEKVDLLRPPSNFPVAESTYTL----CEMTFTWHLYGGRDFPDEPLKKSSSSATSGFGMSDTY 1413
                            |....|.|    .::...|.|:.|.|:  |..:.:.|||......|.:.
pombe  1144 ----------------VEGKNYLLKVKFKDINVNWDLHDGYDW--EATRATISSAIEKLCDSSSQ 1190

  Fly  1414 KYGVSQAQE----QDKQDKKGSKKGLL-----KQPKGSQRNLEVL-----------------VEM 1452
            ...:|...:    |....|..||.|.|     .:|..|....:.|                 :.:
pombe  1191 NDKISPEAKTLLFQSIVIKSFSKVGRLNINHVSEPIDSDEFADYLSKSISYHLRLGKSKSKKIGI 1255

  Fly  1453 QLSKIRFSYETYPLTSMYSSRQVLLVSEIE-------IRDRLRSSDINKFLYHPTGNNLSHKPDE 1510
            ::..::.|:..|    ..|:....::::::       |.|.|.:|..|||....:.:..|...::
pombe  1256 EIKDLQGSFTVY----ADSNEPNAVLNDLDIGLKDLIIYDHLSTSTWNKFFGRDSRSPSSKNRNQ 1316

  Fly  1511 NMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNIDQDTLLFLEDFFSGMFRNSASAAGGTKTEG 1575
            :| ..:.:.|||.|:.:: .|..|..|:||.|:.||||||.||..|.:            .:|..
pombe  1317 HM-NAQIVTVRPLPELNN-RELRLEFSVLPCKMYIDQDTLDFLIRFLT------------FQTPS 1367

  Fly  1576 SSSSATDMPVMSVSKMPEELSDKLPDSEVKEMVERNLNVLIEENSLDVELEEDPATAPPVFFREV 1640
            ||.:....|             .||                                   ||:.:
pombe  1368 SSETLNTEP-------------DLP-----------------------------------FFQSI 1384

  Fly  1641 IFSPALPICFDYHGR---RIELSRGPVTGLIMGLAQLQGSGINLREIVNRRGILGWNKLCEFLAK 1702
            ..: |..:..|:..:   ::.|..|.:..| ..|..:|||.:.||:: ...|:.|..:....|..
pombe  1385 CIN-ATHVTIDFKFKSADKVGLRSGKLPDL-GSLIVMQGSEVFLRQL-QIYGLSGAEEFLNALLN 1446

  Fly  1703 EWLKDIKRNQLPNILSGIGPTNAVLQLFQGIYDLFRLPIE--QYNKDGRIIRGFQLGAQSFTART 1765
            .||:||:.|||..:|:|:.|...:..:.:||.|:|..|:.  |.|..   :..|:.|...||.:.
pombe  1447 VWLQDIRNNQLSKVLNGVVPIRTMFTVGRGIKDIFVSPVRGLQGNHS---VGSFRHGIIKFTEKY 1508

  Fly  1766 ALAALEITSRIIHLLQFTAETTFDMLSAGPSMKKRKGGRQGKRRR-----QGRPKDLREGVANAY 1825
            ....|.:.::       .|..|..:|....|..:|.........|     ..:|:.:.:|:...|
pombe  1509 VNDFLSLNAQ-------GATGTHSLLRQAESYLERGSNASASASRARSYYAEQPETIEQGLRQGY 1566

  Fly  1826 TIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLI 1890
            :.:::|:..:.:||:.........|...|....|.|::|.:|:.|.:.||:|.:..|.|..:||.
pombe  1567 SGLKQGLLGAKSTLMGLPRETRSHKSLGGVAQTVGRKVPLIVLQPMIGATEAVSKTLLGLSNSLQ 1631

  Fly  1891 PEAKLEARDKWKQ 1903
            |:.:.:.|:|:|:
pombe  1632 PQRRQDMREKYKR 1644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg2	NP_001261341.1	Chorein_N	17..117	CDD:289396	22/109 (20%)
		ATG_C	1814..1902	CDD:286423	23/87 (26%)
atg2	NP_001342784.1	Chorein_N	26..134	CDD:315323	23/132 (17%)
		ATG2_CAD	857..1005	CDD:315899	25/148 (17%)
		ATG_C	1554..1643	CDD:312735	23/88 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I3416
eggNOG	1	0.900	-	-		E1_KOG2993
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002365
OrthoInspector	1	1.000	-	-		oto100571
orthoMCL	1	0.900	-	-		OOG6_102791
Panther	1	1.100	-	-	LDO	PTHR13190
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R107
SonicParanoid	1	1.000	-	-		X1792
TreeFam	0	0.000	Not matched by this tool.
	8	7.930