DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg2 and Atg2a

DIOPT Version :9

Sequence 1:	NP_001261341.1	Gene:	Atg2 / 38344	FlyBaseID:	FBgn0044452	Length:	1906	Species:	Drosophila melanogaster
Sequence 2:	XP_006531835.1	Gene:	Atg2a / 329015	MGIID:	1916291	Length:	1916	Species:	Mus musculus

Alignment Length:	2119	Identity:	609/2119 - (28%)
Similarity:	950/2119 - (44%)	Gaps:	427/2119 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFNPWDG-LKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLFEDQGW 66
            |..||.. :|.::||||||.|||.||:.:|:|:||.:|||.|...:.||.|:..:.|:.......
Mouse     4 WLWPWSNCVKERVCRYLLQHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLETWSVNEFLRSMES 68

  Fly    67 AFEVVSGHIGRLTVVVPWNALMTNDSSLEIHNLTITLRPVTRYQSGTTMLESM-WSS-VSSSMQM 129
            ..|:|.|.:..:.|.|||.||:|:..::.:..|.:||:|  |..||....:|. |:| :::|:|:
Mouse    69 PLELVEGFVSSIEVAVPWAALLTDHCTVCVSGLQLTLQP--RQGSGPGAADSQSWASCMTTSLQL 131

  Fly   130 AEECMKQ---VDDDVPFLNHNNALIGLEKFAETIDNVLNRIRAKLTNTTLNIEYILPRSDRKLVL 191
            |:||:::   ...:.|     ..|.|||.||:||:.||.||:....||.:.:|:.|...||.:.:
Mouse   132 AQECLREGLPEPSEPP-----QPLEGLEMFAQTIETVLRRIKVTFLNTVVRVEHSLGDEDRSVAV 191

  Fly   192 SFQASHVEYKNKTGYEMPMSTSQDTETEEDPNSSFNALPMIAKHN--------LVIEGLSLHTSE 248
            ..:...:||.:              |...||:.:    |.:..|.        |.:.|:.|:..|
Mouse   192 EVRVQRLEYCD--------------EAVRDPSQA----PPVDVHQPPAFLHKLLQLSGVCLYFEE 238

  Fly   249 VLDVMDHQFGPTPYEQLCKIVELKGAQNIQINIKQTENIVGPKVSLELSLDDIYFMLTPRQIHLL 313
            :....|      |.:...:|....|...:.:.:||.|...|||:.:...|..::.:|||||:..|
Mouse   239 LPSQAD------PPQPPLQIGSCTGYVELMVRLKQNEAFPGPKLEVSGQLGSLHLLLTPRQLQQL 297

  Fly   314 IEFSKGFNC---GGQQERPKKGRSL-----------------KSAPPSEYQMHSLQQPTRM--TG 356
            .......|.   .|..::..|.|.|                 ..|......::.:..|..:  |.
Mouse   298 QRLLSAVNLADPAGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAESLSLYPITNPLNLDSTD 362

  Fly   357 ILGQNADWCTGMSEADPSEYSVY-----------------GNPPRSGYARSRKMSESTNSMVTSC 404
            :....|...:.::.| .||.|||                 ..||.||    .||:.:.....|..
Mouse   363 LFFSMAGLTSSVTSA-VSELSVYSVDLGSSVHSNMAFHRPSTPPHSG----GKMAPTPLLDTTRP 422

  Fly   405 TNTLQQELGYTEKSGEILKFKVQISKIYGIALHQDILIQNTANIDSCSTVFDHASYLRYSDTASG 469
            .:.::..||                   |::|   .|:|..:.....|.:..|  :....|.|..
Mouse   423 DSLVKMTLG-------------------GVSL---TLLQTASPSSGPSDLPTH--FFAEFDAAKD 463

  Fly   470 FFLGTLLENHIPLQNQQYLLLRAAP---IIVSGSQQRYFQEL--------TSRTTLSATAVDLIE 523
            ...|:...:|:..:.|     ||.|   :.::|:..:...||        ||.|.:....::::|
Mouse   464 GPFGSRDFSHLRPRFQ-----RACPCSHVRLTGTAVQLSWELRTGSHSRRTSSTEVHFGQLEVLE 523

  Fly   524 VL------DNSKEHLLQFDRQ-------RNCPDGYHIRPEIVLTQSSSFMFKQNHNR-----CSN 570
            .|      :.....:|.|...       |.|.   |:|.    ||:...:.|....|     |.:
Mouse   524 CLWPRAATEPEYTEILSFPSHSGSEASARPCA---HLRH----TQTIRRVLKSRSRRSTACHCHS 581

  Fly   571 KIECSLDECTAELDISIYDRLGALFG--SSPFSGDSASSTPYPDDPN-QTEFVVKSENLRLHLRF 632
            ::...|.:..:::::...|||.|||.  ::|....:...|..|.... ||.|.:.:....|.|||
Mouse   582 ELSLDLADFQSDVELGSLDRLAALFRQVTTPSEPPAGLLTEPPQATELQTVFRLSAPRATLRLRF 646

  Fly   633 PVVDGRAANDPLKIPWWKKNVRRDFLAVE-----FRSLVVS-----SRSQISIVSDELDVFYCDA 687
            |:.|.|...|    ||..:.||.:.|.:|     |||.:.|     :.:::.:...:|...|.|.
Mouse   647 PIPDLRPDRD----PWAGQAVRAEQLRLELSEPQFRSELNSGPGPPAPTRLELTCSDLQGIYEDG 707

  Fly   688 DKQSAVHLLKCQQKMQPNKK-----IQIDVLQLKDTSDG------QKKAR--------------- 726
            :| ..|..|:..:.:.|...     :...|:.|...|.|      .:|.|
Mouse   708 EK-PPVPCLRVSKALNPRSTEAKYFLPQVVVTLNPQSSGTQWETAYEKGRDLELSTESPCELQQP 771

  Fly   727 -KSPFSSKCTFGYTSHVEGLDGSVDKTDSLLPGETEEINEFCDSCTQSSKLKIFAFIPHVKVVLE 790
             .||||||.|...|.            :.::||:.||:..|.......|:..:...:|...:.|.
Mouse   772 EPSPFSSKRTMYETE------------EMVIPGDPEEMRTFQSRTLALSRCTLDVIMPSAHIFLP 824

  Fly   791 SKSMYELIYNRLNGDLFMWEPRSPHYDISPDNEVPESKDLYAEPQLEEFR----RNLLLSTSAME 851
            ||.:||.||||:|.||.||||.    |:     :|.|......|....|:    ...|.|.|..|
Mouse   825 SKEVYESIYNRINNDLLMWEPA----DL-----LPTSSAAARPPGSSGFKMCKSAFKLDSDSDEE 880

  Fly   852 SSIYFSMAEPTASAPPAPPVRNEA---FSFELFVEQGTLILFSHLLDPETNQR-SKECGKFQVNL 912
            .:.:||||......|...|.|.::   ||..:.|.:|.:.......| ||.:| ....|:..:::
Mouse   881 DAQFFSMASGVPQTPAPEPSRRQSQSTFSTLVTVLKGRITALCEAKD-ETGKRLDVTHGELVLDV 944

  Fly   913 KELRLFTVNGLDNDSTRSFFSIQLGEIDALHCGNTLQD------LELAWSDLADEKLLPTIYNFA 971
            ::..:|:|..........:|.::..:....|.. .::|      ||:. |.....:|.||||  .
Mouse   945 EQGTIFSVAQYRGQPGLGYFCLEAEKAKLYHRA-AIEDYLLPTHLEVP-SFAPPAQLAPTIY--P 1005

  Fly   972 SVHQQQDRKRM-------EVLSLVAEIKKQPEQRIKRMKMSFGICGAILQHHSCHSEHSWLNQLI 1029
            |.....:|..:       .:||....|...|.:.:|...::..:..|.|:|:....|.||.:||:
Mouse  1006 SEEGVTERGTLGRKGQGPPMLSAAVRIHLDPHKNVKEFLVTVRLHKATLRHYMAPPEQSWHSQLL 1070

  Fly  1030 DFMDVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQRAFLDLGYCTLSSNIISSMSGCTLR 1094
            ||:||.|.|:..|.|..:::.|..|:::..:||||.:.|.|..:.....||||||:...|...||
Mouse  1071 DFLDVLDDPVLGYLPPTVITVLHTHLFSCAVDYRPLYLPVRVLVTAETFTLSSNIVMDTSTFLLR 1135

  Fly  1095 LLAEDCVLQLG-LVKEESND---SLIPVLNLGLLNI---SFRLNAEGS-GQPRVDLRSSIHDMHL 1151
            .:.:|..|.|. ..:.||.|   ..:.||::.||.:   :::.:.||. .||..:||.|.:.:|:
Mouse  1136 FILDDSALYLSDKCEVESLDLRRDYVCVLDIDLLELVIKTWKGSTEGRLSQPLFELRCSNNVVHV 1200

  Fly  1152 KTCYDSAAALAQLIAYVANDRDLCPPEEPILNEDTKPAEPKPNE----EHEMSDHTQNHVSKL-- 1210
            .:|.||.|.|..|:.|:.:..||.||..|          |.|.|    :.::|:...:..|.|
Mouse  1201 HSCADSCALLVNLLQYLTSSGDLHPPPRP----------PSPTEIAGQKVQLSESPASLPSCLPV 1255

  Fly  1211 ---------MADAVIDVESSPNLRAMKSPGG---REEGIEIFYFPDEPKEKRKSTSAKLQTKSLM 1263
                     :.||::|.|........:|.||   :...:.::.||.|    |....|.|.
Mouse  1256 ETALINQRDLTDALLDTERRGLQELAQSSGGPLPQASPVSVYLFPGE----RSGAQAPLP----- 1311

  Fly  1264 VESPSVIGDILDFESNVILQSYYHQSQVQPQTS---LGSQVQQELGSLGNASLEERDFDIIHDEE 1325
                                        .|..|   |||:.::      :.:.||.|.|.:..:|
Mouse  1312 ----------------------------PPGASSHTLGSKAKE------HENEEEGDGDTLDSDE 1342

  Fly  1326 ISRMDKFG-----------VKQIYISEDPLQIVDNHFELPHEKVDLLRPPSNFPVAESTYTLCEM 1379
            ...:|..|           |.|::  ..|:.:.|.||..|....||||.|::|||..|...|.|:
Mouse  1343 FCILDAPGLGIAPRDGEPIVTQLH--PGPIIVHDGHFSQPLGSTDLLRAPAHFPVPSSRVVLREV 1405

  Fly  1380 TFTWHLYGGRDFPDEPLKKSSSSATSGFGMSDTYKYGV---------SQAQEQDKQDKKGSKKGL 1435
            :|.||||||||                ||:..||:..|         |::...::.......:|
Mouse  1406 SFIWHLYGGRD----------------FGLHPTYRARVGLTGPRVSPSRSSGPNRPQNSWRTQG- 1453

  Fly  1436 LKQPKGSQRNLEVLVEMQLSKIRFSYETYPLTSMYS------------SRQVLLVSEIEIRDRLR 1488
                 |..|..:||:|:||||:.|.:|.||..|..:            |||||:|.|:||||||.
Mouse  1454 -----GIGRQHQVLMEIQLSKVSFQHEVYPEESAIAGGLGQELDERPLSRQVLIVQELEIRDRLA 1513

  Fly  1489 SSDINKFLYHPTGNNLSHKPDENMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNIDQDTLLFL 1553
            :|.|||||:..|...|..:...||:.:|||:|.|. ......||.||||::|::||:|||.|.||
Mouse  1514 TSKINKFLHLHTSERLPRRTHSNMLTIKALHVAPT-SSVGGPECCLRVSMMPLRLNVDQDALFFL 1577

  Fly  1554 EDFFSGMFRNSASAAGGTKTEGSSSSATDMPVMSVSKMPEELSDKLPDSEVKEMVERNLNVLIEE 1618
            :|||:.:                ::|...|.....|:.|.|...: |.|..            |.
Mouse  1578 KDFFTSL----------------AASINPMVPGDTSEAPRETHSR-PGSPQ------------EG 1613

  Fly  1619 NSLDVELEEDPATAP----------PVFFREVIFSPALPICFDYHGRRIELSR-GPVTGLIMGLA 1672
            .|.|.|...:|..||          |::|||..|:..:|||.||||:.:.:.: |...||::|||
Mouse  1614 QSEDTETASNPPEAPGSSHSSSDQQPIYFREFRFTSEVPICLDYHGKHVTVDQVGTFMGLLIGLA 1678

  Fly  1673 QLQGSGINLREIVNRRGILGWNKLCEFLAKEWLKDIKRNQLPNILSGIGPTNAVLQLFQGIYDLF 1737
            ||..|.:.|:.:..|.|:||.:|:..:...|||:||::||||.:|.|:||.::|:|||||..||.
Mouse  1679 QLNCSELKLKRLCCRHGLLGVDKVLCYALNEWLQDIRKNQLPGLLGGVGPMHSVVQLFQGFRDLL 1743

  Fly  1738 RLPIEQYNKDGRIIRGFQLGAQSFTARTALAALEITSRIIHLLQFTAETTFDMLS-AGPSMKKRK 1801
            .||||||.||||:|||.|.||.||.:.||.||||:::|::..:|.||||.:|:|| |.|..:..:
Mouse  1744 WLPIEQYRKDGRLIRGLQRGAASFGSSTASAALELSNRLVQAIQATAETVYDILSPASPVSRSLQ 1808

  Fly  1802 GGRQGKRRRQG-RPKDLREGVANAYTIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQ 1865
            ..|..::.|:| :|.|||||:|.||..|||||.::|.|:.:.|...|:|||.:||||.|:||:|.
Mouse  1809 DKRSSRKLRRGQQPADLREGMAKAYDAVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPP 1873

  Fly  1866 LVVCPAVLATQATTNILGGAKSSLIPEAKLEARDKWKQE 1904
            .||.|.::||:||:|:|||.::.::|:|..:...||:.|
Mouse  1874 TVVKPIIVATEATSNVLGGMRNQILPDAHKDHALKWRLE 1912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg2	NP_001261341.1	Chorein_N	17..117	CDD:289396	38/99 (38%)
Atg2	NP_001261341.1	ATG_C	1814..1902	CDD:286423	43/87 (49%)
Atg2a	XP_006531835.1	Chorein_N	14..111	CDD:372231	38/98 (39%)
		MRS6	43..>240	CDD:227376	61/221 (28%)
		ATG_C	1817..1910	CDD:370441	45/92 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836095
Domainoid	1	1.000	542	1.000	Domainoid score	I265
eggNOG	1	0.900	-	-		E1_KOG2993
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	720	1.000	Inparanoid score	I631
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46464
OrthoDB	1	1.010	-	-		D18730at33208
OrthoFinder	1	1.000	-	-		FOG0002365
OrthoInspector	1	1.000	-	-		otm42541
orthoMCL	1	0.900	-	-		OOG6_102791
Panther	1	1.100	-	-	LDO	PTHR13190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R107
SonicParanoid	1	1.000	-	-		X1792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800