DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg2 and ATG2A

DIOPT Version :9

Sequence 1:	NP_001261341.1	Gene:	Atg2 / 38344	FlyBaseID:	FBgn0044452	Length:	1906	Species:	Drosophila melanogaster
Sequence 2:	XP_011543165.1	Gene:	ATG2A / 23130	HGNCID:	29028	Length:	1940	Species:	Homo sapiens

Alignment Length:	2137	Identity:	603/2137 - (28%)
Similarity:	950/2137 - (44%)	Gaps:	439/2137 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFNPWDG-LKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLFEDQGW 66
            |..||.. :|.::|||||..|||.||:.:|:|:||.:|||.|...:.||.|::.:.|::.|....
Human     4 WLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMES 68

  Fly    67 AFEVVSGHIGRLTVVVPWNALMTNDSSLEIHNLTITLRPVTRYQSGTTMLESMWSSVSSSMQMAE 131
            ..|:|.|.:|.:.|.|||.||:|:..::.:..|.:||:|......|....:|..|.:::|:|:|:
Human    69 PLELVEGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQ 133

  Fly   132 ECMKQVDDDVPFLNH-NNALIGLEKFAETIDNVLNRIRAKLTNTTLNIEYILPRSDRKLVLSFQA 195
            ||::   |.:|..:. ...|.|||.||:||:.||.||:....:|.:.:|:.....:|.:.:..:.
Human   134 ECLR---DGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEHSPGDGERGVAVEVRV 195

  Fly   196 SHVEYKNKTGYEMPMSTSQDTETEEDPNSSFNALPMIAKHN--------LVIEGLSLHTSEVLDV 252
            ..:||.:              |...||:.:    |.:..|.        |.:.|:.||..|:
Human   196 QRLEYCD--------------EAVRDPSQA----PPVDVHQPPAFLHKLLQLAGVRLHYEEL--- 239

  Fly   253 MDHQFGPT---PYEQLCKIVELKGAQNIQINIKQTENIVGPKVSLELSLDDIYFMLTPRQIHLLI 314
                  |.   |.|...:|....|...:.:.:||.|...|||:.:...|..::.:|||||:..|.
Human   240 ------PAQEEPPEPPLQIGSCSGYMELMVKLKQNEAFPGPKLEVAGQLGSLHLLLTPRQLQQLQ 298

  Fly   315 EFSKGFNC---GGQQERPKKGRSL------------------------KSAPPSEYQMHSLQQPT 352
            |.....:.   .|..::..|.|.|                        .|..|....:.:|....
Human   299 ELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLDNTD 363

  Fly   353 RMTGILGQNADWCTGMSEADPSEYSVYGNPPRSGYARSRKMSESTNSMVTSCTNTLQQELGYTEK 417
            ....:.|..:...:.:||...|:..: .:..||..| ||::|...:.......|.|..    |.:
Human   364 LFFSMAGLTSSVASALSELSLSDVDL-ASSVRSDMA-SRRLSAQAHPAGKMAPNPLLD----TMR 422

  Fly   418 SGEILKFKVQISKIYGIALHQDILIQNTANIDSCSTVFDHASYLRYSDTASGFFLGTLLENHIPL 482
            ...:||.     .:.|:.|   .|:|.:|.......:..| .:..:..|..|.| |:...:|:..
Human   423 PDSLLKM-----TLGGVTL---TLLQTSAPSSGPPDLATH-FFTEFDATKDGPF-GSRDFHHLRP 477

  Fly   483 QNQQYLLLRAAP---IIVSGSQQRYFQELTS-----RTTLSATAVDLIEVLD-------NSKEH- 531
            :.|     ||.|   :.::|:..:...||.:     |||........:|||:       :..|:
Human   478 RFQ-----RACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYT 537

  Fly   532 -LLQFD-------RQRNCPDGYHIRPEIVLTQSSSFMFKQNHNR-----CSNKIECSLDECTAEL 583
             :|.|.       ..|.|.   |:|...:|.:    :.|....|     |.:::...|....|::
Human   538 EILTFPGTLGSQASARPCA---HLRHTQILRR----VPKSRPRRSVACHCHSELALDLANFQADV 595

  Fly   584 DISIYDRLGALFGSSPFSGDSAS---STPYPDDPNQTEFVVKSENLRLHLRFPVVDGRAANDPLK 645
            ::...|||.||...:....:..:   :.|.|....||.|.:.:....|.||||:.|.|...|
Human   596 ELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQQTVFRLSAPRATLRLRFPIADLRPEPD--- 657

  Fly   646 IPWWKKNVRRDFLAVE-----FRSLVVSS-----RSQISIVSDELDVFYCDADKQSAVHLLKCQQ 700
             ||..:.||.:.|.:|     |||.:.|.     .:.:.:...:|...|.|..| ..|..|:..:
Human   658 -PWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGK-PPVPCLRVSK 720

  Fly   701 KMQP-------------------NKKIQIDV-------LQLKDTSDGQ-KKARKSPFSSKCTFGY 738
            .:.|                   :...|.:|       |:|...|..: ::...||||||.|...
Human   721 ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYE 785

  Fly   739 TSHVEGLDGSVDKTDSLLPGETEEINEFCDSCTQSSKLKIFAFIPHVKVVLESKSMYELIYNRLN 803
            |.            :.::||:.||:..|.......|:..:...:|.|.:.|.||.:||.||||:|
Human   786 TE------------EMVIPGDPEEMRTFQSRTLALSRCSLEVILPSVHIFLPSKEVYESIYNRIN 838

  Fly   804 GDLFMWEPR----SPH-------------------------------YDISPDNEVPESKDLYAE 833
            .||.||||.    :|.                               :|::||:   :|.|
Human   839 NDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDS---DSDD---- 896

  Fly   834 PQLEEFRRNLLLSTSAMESSIYFSMAE---PTASAPPAPPVR-NEAFSFELFVEQGTLILFSHLL 894
                             |.:.:||:..   |.|:||.||.:. ...||..:.|.:|.:.......
Human   897 -----------------EDAHFFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETK 944

  Fly   895 DPETNQRSKECGKFQVNLKELRLFTVNGLDNDSTRSFFSIQLGEIDALHCGNTLQDLEL-AWSDL 958
            |....:.....|:..::::...||:|:.........:|.:: .|...|:....:.|..| :..||
Human   945 DEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLE-AEKATLYHRAAVDDYPLPSHLDL 1008

  Fly   959 AD----EKLLPTIY--------NFASVHQQQDRKRMEVLSLVAEIKKQPEQRIKRMKMSFGICGA 1011
            ..    .:|.||||        ..||..:.|.| ...:||....|...|.:.:|...::..:..|
Human  1009 PSFAPPAQLAPTIYPSEEGVTERGASGRKGQGR-GPHMLSTAVRIHLDPHKNVKEFLVTLRLHKA 1072

  Fly  1012 ILQHHSCHSEHSWLNQLIDFMDVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQRAFLDLG 1076
            .|:|:....|.||.:||::|:||.|.|:..|.|..:::.|..|:::..:||||.:.|.|..:...
Human  1073 TLRHYMALPEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAE 1137

  Fly  1077 YCTLSSNIISSMSGCTLRLLAEDCVLQLG-LVKEESND---SLIPVLNLGLLNI---SFRLNAEG 1134
            ..|||||||...|...||.:.:|..|.|. ..:.|:.|   ..:.||::.||.:   :::.:.||
Human  1138 TFTLSSNIIMDTSTFLLRFILDDSALYLSDKCEVETLDLRRDYVCVLDVDLLELVIKTWKGSTEG 1202

  Fly  1135 S-GQPRVDLRSSIHDMHLKTCYDSAAALAQLIAYVANDRDLCPPEEPILNEDTKPAEPKPNE--- 1195
            . .||..:||.|.:.:|:.:|.||.|.|..|:.||.:..||.||..|          |.|.|
Human  1203 KLSQPLFELRCSNNVVHVHSCADSCALLVNLLQYVMSTGDLHPPPRP----------PSPTEIAG 1257

  Fly  1196 -EHEMSDHTQNHVS-----------KLMADAVIDVESSPNLRAMKSPGG----REEGIEIFYFPD 1244
             :.::|:...:..|           :.:|||::|.|.|  ||.:..|.|    :...|.::.||.
Human  1258 QKVQLSESPASLPSCPPVETALINQRDLADALLDTERS--LRELAQPSGGHLPQASPISVYLFPG 1320

  Fly  1245 EPKEKRKSTSAKLQTKSLMVESPSVIGDILDFESNVILQSYYHQSQVQPQTSLGSQVQQELGSLG 1309
            |             .......||.|.|                     |..||||..:::    .
Human  1321 E-------------RSGAPPPSPPVGG---------------------PAGSLGSCSEEK----E 1347

  Fly  1310 NASLEERDFDIIHDEEISRMDKFG-----------VKQIYISEDPLQIVDNHFELPHEKVDLLRP 1363
            :...||.|.|.:..:|...:|..|           |.|::  ..|:.:.|.:|..|....||||.
Human  1348 DEREEEGDGDTLDSDEFCILDAPGLGIPPRDGEPVVTQLH--PGPIVVRDGYFSRPIGSTDLLRA 1410

  Fly  1364 PSNFPVAESTYTLCEMTFTWHLYGGRDFPDEPLKKSSSSATSGFGMSDTYKYGVSQAQEQDKQDK 1428
            |::|||..:...|.|::..|||||||||...|..::.:      |:|.. :...|:....::...
Human  1411 PAHFPVPSTRVVLREVSLVWHLYGGRDFGPHPGHRART------GLSGP-RSSPSRCSGPNRPQN 1468

  Fly  1429 KGSKKGLLKQPKGSQRNLEVLVEMQLSKIRFSYETYP-------------LTSMYSSRQVLLVSE 1480
            ....:|      ||.|...||:|:||||:.|.:|.||             |.....||||.:|.|
Human  1469 SWRTQG------GSGRQHHVLMEIQLSKVSFQHEVYPAEPATGPAAPSQELEERPLSRQVFIVQE 1527

  Fly  1481 IEIRDRLRSSDINKFLYHPTGNNLSHKPDENMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNI 1545
            :|:||||.||.||||||..|...:..:...||:.:|||:|.|. ......||.||||::|::||:
Human  1528 LEVRDRLASSQINKFLYLHTSERMPRRAHSNMLTIKALHVAPT-TNLGGPECCLRVSLMPLRLNV 1591

  Fly  1546 DQDTLLFLEDFFSGMF---------RNSASAAGGTKTEGSS-----------SSATDMPVMSVSK 1590
            |||.|.||:|||:.:.         ..||.|...|:.:.||           :.:.:.|....|.
Human  1592 DQDALFFLKDFFTSLVAGINPVVPGETSAEARPETRAQPSSPLEGQAEGVETTGSQEAPGGGHSP 1656

  Fly  1591 MPEELSDKLPDSEVKEMVERNLNVLIEENSLDVELEEDPATAPPVFFREVIFSPALPICFDYHGR 1655
            .|       ||.:                              |::|||..|:..:||..||||:
Human  1657 SP-------PDQQ------------------------------PIYFREFRFTSEVPIWLDYHGK 1684

  Fly  1656 RIELSR-GPVTGLIMGLAQLQGSGINLREIVNRRGILGWNKLCEFLAKEWLKDIKRNQLPNILSG 1719
            .:.:.: |...||::|||||..|.:.|:.:..|.|:||.:|:..:...|||:||::||||.:|.|
Human  1685 HVTMDQVGTFAGLLIGLAQLNCSELKLKRLCCRHGLLGVDKVLGYALNEWLQDIRKNQLPGLLGG 1749

  Fly  1720 IGPTNAVLQLFQGIYDLFRLPIEQYNKDGRIIRGFQLGAQSFTARTALAALEITSRIIHLLQFTA 1784
            :||.::|:|||||..||..||||||.||||::||.|.||.||.:.||.||||:::|::..:|.||
Human  1750 VGPMHSVVQLFQGFRDLLWLPIEQYRKDGRLMRGLQRGAASFGSSTASAALELSNRLVQAIQATA 1814

  Fly  1785 ETTFDMLS-AGPSMKKRKGGRQGKRRRQG-RPKDLREGVANAYTIVREGINESANTLIEAAITEH 1847
            ||.:|:|| |.|..:..:..|..:|.|:| :|.|||||||.||..|||||.::|.|:.:.|...|
Human  1815 ETVYDILSPAAPVSRSLQDKRSARRLRRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGH 1879

  Fly  1848 DQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEAKLEARDKWKQE 1904
            :|||.:||||.|:||:|..||.|.:|||:||:::|||.::.::|:|..:...||:.:
Human  1880 EQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQIVPDAHKDHALKWRSD 1936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg2	NP_001261341.1	Chorein_N	17..117	CDD:289396	37/99 (37%)
Atg2	NP_001261341.1	ATG_C	1814..1902	CDD:286423	44/87 (51%)
ATG2A	XP_011543165.1	Chorein_N	14..108	CDD:289396	37/93 (40%)
ATG2A	XP_011543165.1	ATG_C	1841..1934	CDD:286423	46/92 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146020
Domainoid	1	1.000	528	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2993
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	711	1.000	Inparanoid score	I650
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46464
OrthoDB	1	1.010	-	-		D18730at33208
OrthoFinder	1	1.000	-	-		FOG0002365
OrthoInspector	1	1.000	-	-		otm40464
orthoMCL	1	0.900	-	-		OOG6_102791
Panther	1	1.100	-	-	LDO	PTHR13190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R107
SonicParanoid	1	1.000	-	-		X1792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800