DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg2 and atg-2

DIOPT Version :9

Sequence 1:	NP_001261341.1	Gene:	Atg2 / 38344	FlyBaseID:	FBgn0044452	Length:	1906	Species:	Drosophila melanogaster
Sequence 2:	NP_509145.3	Gene:	atg-2 / 180949	WormBaseID:	WBGene00019748	Length:	2290	Species:	Caenorhabditis elegans

Alignment Length:	2484	Identity:	495/2484 - (19%)
Similarity:	884/2484 - (35%)	Gaps:	784/2484 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSWFN-PWDGLKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLFEDQ 64
            :|.|| .|       |:.:||||:|.:.:|||:::||.::|.||...::::.:...|.::.|...
Worm     3 LSTFNRVW-------CKVMLQRYMGAWLDNNLSVDQLSLELANGCLELDNLDINTKAVSNGFLQC 60

  Fly    65 GWAFEVVSGHIGRLTVVVPWNALMTNDSSLEIHNLTITLR-----PVTRYQSGTTMLESMWSSVS 124
            ....:::.|::|::.:.:||.:|||:.:.:.|.:|.:|.|     .:...::.|:|:||:...:|
Worm    61 NIPLKLIDGYLGKIKIEIPWLSLMTDPTRMCIEDLQLTFRGAEVMKINDIETLTSMIESVLMGLS 125

  Fly   125 SSMQMAEECMKQVDDDVPFLNHNNA---LIG----LEKFAETIDNVLNRIRAKLTNTTLNIEYIL 182
            :. .||....::|..:      ||.   |:|    .:.|:..||.|.:|...|:.:.||..| ..
Worm   126 TD-DMARSVYEEVSKE------NNVASELLGPDDTADSFSGFIDAVYSRFCLKIKHLTLRFE-TD 182

  Fly   183 P--RSDRKLVLSFQASHVEYKNK--TGYEMPMSTSQDTETEEDPNSSFNALPMIAKHNLVIEGLS 243
            |  ||.....|..:...:.:.::  ...||..:.:.|..|.: |:...:...:  :.||...|::
Worm   183 PKNRSTMATALEIRVETITFMDEQMRSCEMDHTNATDLVTTQ-PHGVVSTTNL--RKNLTFSGVT 244

  Fly   244 LHT--------------SEVLDVMDH-------QFGPTP------------------------YE 263
            .||              ..||....|       |..||.                        |:
Worm   245 FHTDVFSQINNDGMGDEENVLITSMHIRREKAKQMSPTKSVQNSLHPEMFQSAMSDMDAFHSCYD 309

  Fly   264 QL----C----------------------KIVELKGAQNIQINIKQTENIVG------PKVSLEL 296
            :|    |                      :..|:.|..:....||...|.|.      .||..::
Worm   310 KLTQDYCSPDQLETLRTAPAEPELFSAPIQCAEVVGDISCVFRIKNGANDVNYADVDESKVETDV 374

  Fly   297 SLDDIYFMLTPRQIHLLIEFSKGFNCGGQQERPKKGRSLKSAPPSEYQMHSLQQPTRMTGILGQN 361
            .:..|....||.||.::..|....                 ..|.|..:|...:|.       ..
Worm   375 FIKGINVFATPSQIEIVNRFFSSI-----------------VTPKELVVHEQGKPM-------SK 415

  Fly   362 ADWCTGMSEADPSEYSVYGNPPRSGYA--------------------RSRKMSESTNSMVTSCTN 406
            .|:.......:|::.:   .||.:|.:                    :.::.||.........:.
Worm   416 EDYENMTKNMEPNQSN---EPPMAGASFGGNWNVGEVFREFDDLKSIKEKEKSEKEKFKSLKASG 477

  Fly   407 TLQQELGYTEKSGEILKFKVQISKIYGIALHQDILIQNTANIDSCSTVFDHASY---LRY-SDTA 467
            .:::|.......|.:|.:          ..|.|.:..:.|.        .|..|   |.| ...:
Worm   478 NIKEEFTVNTHIGTVLMY----------IPHCDYMSSDYAQ--------QHGGYANVLNYLKKES 524

  Fly   468 SGFF-------------LGTLLENHIPLQNQQYLLLRAAPIIVSGSQQRYFQELTSRTTLSATAV 519
            ..||             |..:.:.......:.:|.:....:.::.|.:|.....:....:.||..
Worm   525 ESFFKSIQGYSFMSKHGLANIRQQSDSFYPKDHLRIVGGSLGITSSCKRVGNVDSFLCRVVATHF 589

  Fly   520 DLIEVL------DNS---KEHLLQFDRQRNCPDGYHIRPEIVLTQSSSFMFKQNHNRCSNKIECS 575
            |::|.|      :||   :..||.:..|.|.....:.:  :||:.||       ..:...|::..
Worm   590 DMLEYLTPESAPENSTPIRIGLLDYSEQENLESDPNFK--MVLSTSS-------EQKGLTKVDIL 645

  Fly   576 LDECTAELDISIYDRLGALFGSSPF-----------------SGDSASSTPYPDDPNQTEFVV-- 621
            |.....|||.||.||:..|....||                 ..|..|.....:|..:::.:|
Worm   646 LGAVKTELDFSIIDRISNLIACRPFFDEALTNYGNRNTVPQLKDDLYSDVLIAEDDVKSKTLVNL 710

  Fly   622 KSENLRLHLRFPVVDGRAANDPL--KIPWWKKNVRRDFLAVEFRSLVVS-----SRSQISIVSDE 679
            |..|.::.||.|..|.|   ||.  ::|:.:::|..:||.:..:.:.||     |.:.|.|:..|
Worm   711 KCSNWQVDLRIPKADLR---DPTGSRLPFSQRHVHNEFLRLGIKEIDVSIPIEKSVTLIEILCTE 772

  Fly   680 LDVFYCDADKQSAVHLLKCQQKMQPNKKIQIDVLQLKDT--SDGQK------------------- 723
            :...:|.    ..:::.|.||::....|...|.:.||.|  ||.:|
Worm   773 MIGDFCG----EGLNIPKQQQRILHASKNGFDKINLKLTLCSDAKKLPGCGRKTSTSGIPDSMMK 833

  Fly   724 ----------KARKSPFSSKCTFGYTSHVEGLDGSVDKTDSLL-PGETEEINEFCDSCTQSSKLK 777
                      ..::.|| ||....|.||    ||  ::|:.:: .|..:||.:|.:.|...:...
Worm   834 SVSADIMMAHPKKEGPF-SKVPRSYCSH----DG--EETEEIIQAGTRKEILDFQEECQNFASTF 891

  Fly   778 IFAFIPHVKVVLESKSMYELIYNRLNGDLFMWEPRSPHY--------DISPDNEVPE--SKDLYA 832
            :...:|.:|:.:..|:..|::||||..||.:::|.:|.:        ::.|.....|  |...||
Worm   892 MLFTVPVLKLHIPEKNFLEILYNRLVNDLALFQPAAPAFRNNQSTNSNVQPLESFQECVSPKNYA 956

  Fly   833 EPQLEEFRRNLLLSTSAMESSIYFSMAEPTASAPPAPPVRNEAFSFELFVEQGTLILFSHLLDPE 897
            |.:..:...::.....::| |:.|....|            ..|...|...:.|::..:.:.:.|
Worm   957 ESEHSDLDDDVATLHESIE-SLNFDRDIP------------HTFVMTLNANKCTVLCNTAIKEAE 1008

  Fly   898 TNQRSKECGKFQVNLKELRLFTVNGLDNDSTRSFFSIQLGEIDALHCGNTLQDLELAWSDLADEK 962
               :..|..:..::|:::.:.|..|...|...::|.....:               |.:...|..
Worm  1009 ---KQPESSQVSLDLEKVHIGTTAGYHGDINHTYFHFTSSK---------------AAAGSIDSP 1055

  Fly   963 LLPTIYNFASVHQ----QQDRKRMEVLSLVAEIKK---------------QPEQRIKRMKMSFGI 1008
            ..|.|.|..|...    .:|..::|.:.:..|:..               :|:..:|.:.:...:
Worm  1056 RAPRIPNLISAKDFGKWTKDCNQLEHVPITDELSSGSTEDAFAVALHMHFRPDVNMKDVLLGIAL 1120

  Fly  1009 CGAILQHHSC-HSEHSWLNQLIDFMDVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQRAF 1072
            ..:.||.... |....|:.||.|...:.|:.|..||..::.::|.:...||.|.|...:....:.
Worm  1121 RNSQLQAKPFRHWGAFWITQLADLFTLQDYAIPGYELPSVSTDLHICFENAIIGYDHAWVNPNSK 1185

  Fly  1073 L----DLGYCTLSSNIISSMSGCTLRLLAEDCVLQLG--LVKEE-----------SNDSLIPVLN 1120
            |    .||.|.|:|:|:|.|:......:.|.|.|.:.  |.|:.           |....||.|:
Worm  1186 LKLRATLGQCNLASSIVSDMNISKTLCIFESCRLYMSNDLTKDAVRFEGYGTQKVSPKKFIPFLD 1250

  Fly  1121 LG--LLNISFRLNAEGSG---QPRVDLRSSIHDMHLKTCYDSAAA-LAQLIAYVANDR-DLCPPE 1178
            ||  .|:|.|.:..| :|   .|..::|.....::...|.||.|. :..::.|.:::: .:..||
Worm  1251 LGSVQLDILFAVGDE-TGLRTNPTFEIRCQNDIINAWACADSLATFMKTVMEYTSHEQIPIKTPE 1314

  Fly  1179 EPI--LNEDTKPAEPKPN--EEHEMSDHT--QNHVSKLMADAVIDVESSPNLRAMKSPGGRE--- 1234
            |..  |.:.||..:...:  .|...||.:  ..|:.|:...|.:..:....::||......|
Worm  1315 EESQELMKSTKTDDINKSVAGESVWSDASTGSKHIQKMTVGANLPDDVEKRIQAMIQEAVNENDE 1379

  Fly  1235 -EGIEIFYFPDEPKEKRKSTSAKLQTKSLMVESPSVIGDILDFESNVILQSYYHQSQVQPQTSLG 1298
             :||.|       .|......|.:|.|               .::|...:|:.|.:.
Worm  1380 RDGIAI-------GEDAVREFATIQPK---------------HDANETNESFEHVAS-------- 1414

  Fly  1299 SQVQQELGSLGNASLEERDFDIIHDEEI----------SRMDKFGVKQIYISEDPL--------Q 1345
                      .|.|:.:.:|.::.|...          ||......||  :.|:||        .
Worm  1415 ----------RNFSVTDDEFCMVDDNIFGSGITIQPGESRTRPMPAKQ--LPEEPLINGSEFFQT 1467

  Fly  1346 IVDNHFELPHEKVD-----LLRPPSNFPVAESTYTLCEMTFTWHLYGGRDF--PDEPLKK-SSSS 1402
            |.|:..:..::.:.     :||           |.|.::|....||.|.|.  ...|:|. .:..
Worm  1468 IEDSGSDALYQTMSGQINPVLR-----------YFLKDVTVRLSLYAGNDLSTSPSPIKTYCTEE 1521

  Fly  1403 ATSGFGMSDTYKYGVSQAQEQDKQDKKGSKKGLLKQPKGSQRNLEVLVEMQLSKIRFSYETYPLT 1467
            ..:|||           .:::.:|:..|          |..|:....|..:||||.:..:.:..|
Worm  1522 YRNGFG-----------PEQKIEQNSTG----------GPNRDHSAFVVFELSKITYLKQIFDKT 1565

  Fly  1468 SMYSSRQVLLVSEIEIRDRLRSSDINKFLYHPTGNNLSHKPDENMVIVKALNVRPNPQKSSAEEC 1532
            :...|..:..|::|.|:|.:|:|||.:.||..:..|...:....:|.|:.       .::.::|.
Worm  1566 APMLSTTLFQVNDIVIKDCVRASDIKEMLYQYSVTNQPRRATAPIVTVRM-------SETHSKEG 1623

  Fly  1533 SLRVSILPIKLNIDQDTLLFLEDFFS------GMFRNSASA-------------AGGTKT----- 1573
            .:|||:||||:|:|||||.||.|||.      .:.:|..|.             .|..||
Worm  1624 KMRVSMLPIKINVDQDTLEFLTDFFEETSKLLDLPKNQMSMPLIQRPVIEVPADIGSKKTTPKTS 1688

  Fly  1574 ----EGS---------SSSAT-------------------------------------DMPV--- 1585
                ||.         |.|.|                                     |.|:
Worm  1689 VSSSEGDIARMYPSIPSPSLTLEPLRPSPVQPPTPLGDLTYLEKISSNHQSPVKRPIIDAPLTAS 1753

  Fly  1586 -MSVSKMPE-------------------------ELSDKL------------------------- 1599
             :|:.|:.|                         ||:::|
Worm  1754 AVSIGKIFERDAHSDEDEEEIIDPIQMAAALEIRELNEELGRIEQLEKKKTDDLFKQSYSSSSSE 1818

  Fly  1600 --------PDSEVKEMVER-------------------------------------NLNV----- 1614
                    ..|:|:.:.|.                                     |.|:
Worm  1819 TESESSAPQSSQVRRLHESLDASNPTGLSDLTGDWADDHDLTYTHHDVVRQESPSFNCNISPIKG 1883

  Fly  1615 ------LIEENSLDVELEED----PATAPPV---------------------------------- 1635
                  |...|.:|.|.|.|    |.|:.|:
Worm  1884 YSPPAELRPLNLMDSETERDSSASPVTSSPIKPARNIKKELPPLKMPRQPLSNDDILMRSTMMGS 1948

  Fly  1636 ----------------------------------------------------------------- 1635

Worm  1949 VHPSQSVHNLVDTSDDLEEHGNFLDSIDNEDDNEKQKIEEEMEEDEKEEEEERNKEIQEAVERGE 2013

  Fly  1636 -FFREVIFSPALPICFDYHG-RRIELSR-GPVTGLIMGLAQLQGSGINLREIVNRRGILGWNKLC 1697
             ||::.:|||::.|..||.| |:|.:.: |.:.||:|...||....||||:|..|.|:||..:..
Worm  2014 TFFKQFVFSPSVNIYVDYQGKRKITMEKAGALVGLLMAFGQLNQMPINLRKIDTRTGLLGTGRCM 2078

  Fly  1698 EFLAKEWLKDIKRNQLPNILSGIGPTNAVLQLFQGIYDLFRLPIEQYNK-DGRIIRGFQLGAQSF 1761
            :....||..|:..| :|::::..||.:.::|:.:|:.|||.:|:.::.| ||.:::|.|.|..||
Worm  2079 QHAIGEWSGDLLTN-MPSVIASYGPISPLVQIGRGVVDLFLMPVAEFRKDDGNVMKGVQRGVGSF 2142

  Fly  1762 TARTALAALEITSRIIHLLQFTAETTF-DMLSAGPSMKKRKGGRQGKRRRQGRPKDLREGVANAY 1825
            :..:|...:.:...:...:|..||.|. ::....||  .|:..|:..|.....|.|:|..:..||
Worm  2143 SVSSAAGIVGMAQTVTGFVQSLAEMTMKEIKPDDPS--TRRVARRYNRNHGMNPTDVRHSLQLAY 2205

  Fly  1826 TIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLI 1890
            .|:.:|.:::.:.|..||  :.|:...:..|.:..|......:.|.|:|||.|..:|||.::.|.
Worm  2206 GILYDGYHQTRDDLELAA--QEDRASGNSVVRSAFRYAVPTFLGPIVMATQVTYQLLGGLRNQLR 2268

  Fly  1891 PEAKLEARDKWKQE 1904
            |:...:.|.||.::
Worm  2269 PDTYQDERRKWGEK 2282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg2	NP_001261341.1	Chorein_N	17..117	CDD:289396	28/104 (27%)
Atg2	NP_001261341.1	ATG_C	1814..1902	CDD:286423	26/87 (30%)
atg-2	NP_509145.3	MRS6	14..>185	CDD:227376	48/178 (27%)
		Chorein_N	15..>97	CDD:372231	24/81 (30%)
		VPS13_C	2014..2171	CDD:374881	52/157 (33%)
		ATG_C	2194..2279	CDD:370441	25/86 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158783
Domainoid	1	1.000	129	1.000	Domainoid score	I3275
eggNOG	1	0.900	-	-		E1_KOG2993
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I1345
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46464
OrthoDB	1	1.010	-	-		D18730at33208
OrthoFinder	1	1.000	-	-		FOG0002365
OrthoInspector	1	1.000	-	-		oto17716
orthoMCL	1	0.900	-	-		OOG6_102791
Panther	1	1.100	-	-	LDO	PTHR13190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R107
SonicParanoid	1	1.000	-	-		X1792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800