DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AhcyL1 and ahcyl1

DIOPT Version :9

Sequence 1:	NP_647746.1	Gene:	AhcyL1 / 38342	FlyBaseID:	FBgn0035371	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_958450.1	Gene:	ahcyl1 / 798918	ZFINID:	ZDB-GENE-021206-7	Length:	512	Species:	Danio rerio

Alignment Length:	477	Identity:	373/477 - (78%)
Similarity:	416/477 - (87%)	Gaps:	4/477 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KKTSRYRSRSLSASSTDSFSS-ASYTGSSEDGDDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRR 109
            |...|..|||:|.|||||:|| ||||.||:  |:..||||.|.||||||||||:|| .|..||||
Zfish    39 KTGRRSLSRSISQSSTDSYSSAASYTDSSD--DETSPREKSQVNSKGSSDFCVKNI-KQAEFGRR 100

  Fly   110 EIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINAQTAVLIETLVELGASVRWAACNIYSTQ 174
            |||||||:|..:|:|:|||..:|||..||:.|||||.|||||||||||.|||..||.||||||||
Zfish   101 EIEIAEQDMSALISLRKRAQGEKPLAGAKVAGCTHITAQTAVLIETLVALGAQCRWTACNIYSTQ 165

  Fly   175 NEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNAENWQPNMILDDGGDATHLMLKKYPTMFKLV 239
            |||||||||||:.:|||:||:|:|||||||||||.:.||.|||||||||.||.:.||||::||.|
Zfish   166 NEVAAALAESGVSVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPSVFKKV 230

  Fly   240 KGIVEESVTGVHRLYQLSKAGKLTVPAMNVNDSVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQ 304
            :||||||||||||||||||||||.||||||||||||.||||||.|:|||||.|||:|||||||||
Zfish   231 RGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQ 295

  Fly   305 VVVCGYGDVGKGCAQALKGQGCIVYITEIDPICALQASMDGFRVVKLNEVIRNVDIVVTATGNKN 369
            |||||||:|||||..|||..|.||.:|||||||||||.||||||||||||:|.:|:|:|.|||||
Zfish   296 VVVCGYGEVGKGCCSALKALGAIVCVTEIDPICALQACMDGFRVVKLNEVVRQMDMVITCTGNKN 360

  Fly   370 VVVREHMDKMKSGCIVCNMGHSNTEIDVNGLRTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLV 434
            ||.|||:|:||:||||||||||||||||..||||:||||:|||||||:|||:||.:||||||||:
Zfish   361 VVTREHLDRMKNGCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRVILLAEGRLL 425

  Fly   435 NLSCSSIPSFAVSITSATQALALIELFNAPPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELS 499
            |||||::|||.:|||:.|||||||||:|||.||||.|||||||||||||||||||.|||||||||
Zfish   426 NLSCSTVPSFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPNFDAHLTELS 490

  Fly   500 DEQAKYMGLNKAGPFKPNYYRY 521
            |||||||||||.||||||||||
Zfish   491 DEQAKYMGLNKNGPFKPNYYRY 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL1	NP_647746.1	AdoHcyase	94..520	CDD:336064	339/425 (80%)
ahcyl1	NP_958450.1	AdoHcyase	86..511	CDD:283003	339/425 (80%)
ahcyl1	NP_958450.1	PRK05476	86..506	CDD:235488	334/420 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581627
Domainoid	1	1.000	282	1.000	Domainoid score	I1614
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77353
Inparanoid	1	1.050	773	1.000	Inparanoid score	I518
OMA	1	1.010	-	-		QHG48638
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	1	1.000	-	-		otm24564
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5762
SonicParanoid	1	1.000	-	-		X2437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800