DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AhcyL1 and ahcyl2a

DIOPT Version :9

Sequence 1:	NP_647746.1	Gene:	AhcyL1 / 38342	FlyBaseID:	FBgn0035371	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_005170753.2	Gene:	ahcyl2a / 791167	ZFINID:	ZDB-GENE-070112-1522	Length:	516	Species:	Danio rerio

Alignment Length:	504	Identity:	349/504 - (69%)
Similarity:	412/504 - (81%)	Gaps:	12/504 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PQDA-------SVVVPPPATKQSSALKKTSRYR-SRSLSASSTDSFSSASYTGSSEDGD-DVPPR 82
            |:||       .:..|....:..:.|.||.|.. |.|||.|||||.||..  ..:||.: :|.||
Zfish    16 PKDAVLSLNIKQIEYPEQTREFDNRLTKTGRRSLSHSLSHSSTDSNSSGG--SDAEDPENEVSPR 78

  Fly    83 EKVQKNSKGSSDFCVRNIGAQHAFGRREIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINA 147
            :|.:.||||:.|||::||.... ||||:||:||.||..::||:|.|..:|||..||||||||:.|
Zfish    79 DKQRMNSKGNKDFCIKNIKLAD-FGRRQIELAEDEMTALMALRKAAQGEKPLAGAKIVGCTHVTA 142

  Fly   148 QTAVLIETLVELGASVRWAACNIYSTQNEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNAENW 212
            |||||.|||..|||..||||||||||||||||||||...|:|||:||:|:|||||||||||.|.|
Zfish   143 QTAVLFETLSGLGAQCRWAACNIYSTQNEVAAALAERDFPVFAWKGESEDDFWWCIDRCVNVEGW 207

  Fly   213 QPNMILDDGGDATHLMLKKYPTMFKLVKGIVEESVTGVHRLYQLSKAGKLTVPAMNVNDSVTKTK 277
            :||||||||||.||.:.||||.:||.||||||||:||:|||:.|||||||.|||:||||||||.|
Zfish   208 EPNMILDDGGDMTHWIYKKYPHIFKKVKGIVEESITGIHRLHHLSKAGKLCVPAINVNDSVTKQK 272

  Fly   278 FDNLYSCKESILDSLKRSTDVMFGGKQVVVCGYGDVGKGCAQALKGQGCIVYITEIDPICALQAS 342
            |||||.|:||||||||::.|:|||||||||||||:|||||:.|||..|.|||:|||||||||||.
Zfish   273 FDNLYCCRESILDSLKKTADIMFGGKQVVVCGYGEVGKGCSAALKAMGSIVYVTEIDPICALQAC 337

  Fly   343 MDGFRVVKLNEVIRNVDIVVTATGNKNVVVREHMDKMKSGCIVCNMGHSNTEIDVNGLRTPDLTW 407
            |||||:.||::|:|.||:|:|.|||||||||||||.||:||:|||||.|||||:|:.|:||||||
Zfish   338 MDGFRLTKLSDVVRQVDMVITCTGNKNVVVREHMDVMKNGCVVCNMGRSNTEINVSALKTPDLTW 402

  Fly   408 EKVRSQVDHIIWPEGKYIILLAEGRLVNLSCSSIPSFAVSITSATQALALIELFNAPPGRYKSDV 472
            :.||:||||||||:||.:|||||||::|||.|::|.:.:|||:.|||||||||||||.||||.||
Zfish   403 QHVRAQVDHIIWPDGKRMILLAEGRVLNLSSSTVPIYVLSITATTQALALIELFNAPEGRYKQDV 467

  Fly   473 YLLPKKMDEYVASLHLPTFDAHLTELSDEQAKYMGLNKAGPFKPNYYRY 521
            ||||||:|||||||||.|||||||||:|:|||||||:|.||||||||||
Zfish   468 YLLPKKLDEYVASLHLQTFDAHLTELTDDQAKYMGLSKNGPFKPNYYRY 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL1	NP_647746.1	AdoHcyase	94..520	CDD:336064	317/425 (75%)
ahcyl2a	XP_005170753.2	PRK05476	88..510	CDD:235488	312/422 (74%)
ahcyl2a	XP_005170753.2	AdoHcyase	90..515	CDD:283003	317/425 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581628
Domainoid	1	1.000	282	1.000	Domainoid score	I1614
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	773	1.000	Inparanoid score	I518
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	1	1.000	-	-		otm24564
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2437
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900