DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AhcyL1 and Ahcyl1

DIOPT Version :9

Sequence 1:	NP_647746.1	Gene:	AhcyL1 / 38342	FlyBaseID:	FBgn0035371	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_008759627.2	Gene:	Ahcyl1 / 362013	RGDID:	1309768	Length:	530	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	370/477 - (77%)
Similarity:	418/477 - (87%)	Gaps:	4/477 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KKTSRYRSRSLSASSTDSFSS-ASYTGSSEDGDDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRR 109
            |...|..|||:|.|||||:|| ||||.||:  |:|.||||.|.||||||:|||:|| .|..||||
  Rat    57 KTGRRSLSRSISQSSTDSYSSAASYTDSSD--DEVSPREKQQTNSKGSSNFCVKNI-KQAEFGRR 118

  Fly   110 EIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINAQTAVLIETLVELGASVRWAACNIYSTQ 174
            |||||||:|..:|:|:|||..:|||..|||||||||.||||||||||..|||..||:||||||||
  Rat   119 EIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQ 183

  Fly   175 NEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNAENWQPNMILDDGGDATHLMLKKYPTMFKLV 239
            |||||||||:|:.:|||:||:|:|||||||||||.:.||.|||||||||.||.:.||||.:||.:
  Rat   184 NEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKI 248

  Fly   240 KGIVEESVTGVHRLYQLSKAGKLTVPAMNVNDSVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQ 304
            :||||||||||||||||||||||.||||||||||||.||||||.|:|||||.|||:|||||||||
  Rat   249 RGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQ 313

  Fly   305 VVVCGYGDVGKGCAQALKGQGCIVYITEIDPICALQASMDGFRVVKLNEVIRNVDIVVTATGNKN 369
            |||||||:|||||..|||..|.|||||||||||||||.||||||||||||||.||:|:|.|||||
  Rat   314 VVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKN 378

  Fly   370 VVVREHMDKMKSGCIVCNMGHSNTEIDVNGLRTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLV 434
            ||.|||:|:||:.|||||||||||||||..||||:||||:|||||||:|||:||.::|||||||:
  Rat   379 VVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLL 443

  Fly   435 NLSCSSIPSFAVSITSATQALALIELFNAPPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELS 499
            |||||::|:|.:|||:.|||||||||:|||.||||.|||||||||||||||||||:||||||||:
  Rat   444 NLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELT 508

  Fly   500 DEQAKYMGLNKAGPFKPNYYRY 521
            |:||||:||||.||||||||||
  Rat   509 DDQAKYLGLNKNGPFKPNYYRY 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL1	NP_647746.1	AdoHcyase	94..520	CDD:336064	335/425 (79%)
Ahcyl1	XP_008759627.2	AdoHcyase	106..529	CDD:214963	334/423 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341641
Domainoid	1	1.000	282	1.000	Domainoid score	I1576
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77353
Inparanoid	1	1.050	773	1.000	Inparanoid score	I509
OMA	1	1.010	-	-		QHG48638
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	1	1.000	-	-		otm45492
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810