DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AhcyL1 and Ahcyl2

DIOPT Version :9

Sequence 1:	NP_647746.1	Gene:	AhcyL1 / 38342	FlyBaseID:	FBgn0035371	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001166981.2	Gene:	Ahcyl2 / 312192	RGDID:	1564895	Length:	612	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	392/576 - (68%)
Similarity:	441/576 - (76%)	Gaps:	72/576 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PGFGGGDKQQQAGPAPQDASVVVPPPA---------------TKQSSALKKT------SRYR--- 52
            |..||||.:   .|||..|:...|.|.               ..|:||:|::      .|:|
  Rat    43 PPAGGGDPE---APAPAPAAERPPAPGPGSGPTAALSPAAGKVPQASAMKRSDPHHQHQRHRDGG 104

  Fly    53 -----------------------------------------SRSLSASSTDSFSS-ASYTGSSED 75
                                                     |||:|.|||||:|| ||||.||:
  Rat   105 EALVSPDGTVTEAPRTVKKIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSD- 168

  Fly    76 GDDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRREIEIAEQEMPGIIALKKRAAEDKPLKDAKIV 140
             |:..||:|.||||||||||||:|| .|..||||||||||||||.::||:|||..:|||..||||
  Rat   169 -DETSPRDKQQKNSKGSSDFCVKNI-KQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIV 231

  Fly   141 GCTHINAQTAVLIETLVELGASVRWAACNIYSTQNEVAAALAESGIPIFAWRGETEEDFWWCIDR 205
            |||||.||||||:|||..|||..||||||||||.|||||||||||.|:|||:||:|:||||||||
  Rat   232 GCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDR 296

  Fly   206 CVNAENWQPNMILDDGGDATHLMLKKYPTMFKLVKGIVEESVTGVHRLYQLSKAGKLTVPAMNVN 270
            |||.|.||||||||||||.||.:.||||.|||.:|||||||||||||||||||||||.|||||||
  Rat   297 CVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVN 361

  Fly   271 DSVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQVVVCGYGDVGKGCAQALKGQGCIVYITEIDP 335
            |||||.||||||.|:|||||.|||:||:|||||||||||||:|||||..|||..|.:||:|||||
  Rat   362 DSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSVVYVTEIDP 426

  Fly   336 ICALQASMDGFRVVKLNEVIRNVDIVVTATGNKNVVVREHMDKMKSGCIVCNMGHSNTEIDVNGL 400
            ||||||.|||||:||||||||.||||:|.|||||||.|||:|:||:.|||||||||||||||..|
  Rat   427 ICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASL 491

  Fly   401 RTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLVNLSCSSIPSFAVSITSATQALALIELFNAPP 465
            |||:||||:|||||||:|||:||.|:|||||||:|||||::|:|.:|||:.|||||||||:|||.
  Rat   492 RTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPE 556

  Fly   466 GRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELSDEQAKYMGLNKAGPFKPNYYRY 521
            ||||.||||||||||||||||||||||||||||:||||||:||||.||||||||||
  Rat   557 GRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL1	NP_647746.1	AdoHcyase	94..520	CDD:336064	343/425 (81%)
Ahcyl2	NP_001166981.2	AdoHcyase	186..611	CDD:283003	343/425 (81%)
Ahcyl2	NP_001166981.2	PRK05476	186..606	CDD:235488	338/420 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341642
Domainoid	1	1.000	282	1.000	Domainoid score	I1576
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	773	1.000	Inparanoid score	I509
OMA	1	1.010	-	-		QHG48638
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	1	1.000	-	-		otm45492
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	LDO	PTHR23420
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2437
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770