DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AhcyL1 and AHCYL2

DIOPT Version :9

Sequence 1:	NP_647746.1	Gene:	AhcyL1 / 38342	FlyBaseID:	FBgn0035371	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_056143.1	Gene:	AHCYL2 / 23382	HGNCID:	22204	Length:	611	Species:	Homo sapiens

Alignment Length:	575	Identity:	393/575 - (68%)
Similarity:	441/575 - (76%)	Gaps:	71/575 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PGFGGGDKQQQAGPAPQDASVVVPPPAT-------------KQSSALKKT------SRYR----- 52
            |..||||.:   .|||......||.|.:             .|:||:|::      .|:|
Human    43 PPAGGGDPE---APAPAAERPPVPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEA 104

  Fly    53 ----------------------------------------SRSLSASSTDSFSS-ASYTGSSEDG 76
                                                    |||:|.|||||:|| ||||.||:
Human   105 LVSPDGTVTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSD-- 167

  Fly    77 DDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRREIEIAEQEMPGIIALKKRAAEDKPLKDAKIVG 141
            |:..||:|.||||||||||||:|| .|..||||||||||||||.::||:|||..:|||..|||||
Human   168 DETSPRDKQQKNSKGSSDFCVKNI-KQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVG 231

  Fly   142 CTHINAQTAVLIETLVELGASVRWAACNIYSTQNEVAAALAESGIPIFAWRGETEEDFWWCIDRC 206
            ||||.||||||:|||..|||..||||||||||.|||||||||||.|:|||:||:|:|||||||||
Human   232 CTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRC 296

  Fly   207 VNAENWQPNMILDDGGDATHLMLKKYPTMFKLVKGIVEESVTGVHRLYQLSKAGKLTVPAMNVND 271
            ||.|.||||||||||||.||.:.||||.|||.:|||||||||||||||||||||||.||||||||
Human   297 VNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVND 361

  Fly   272 SVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQVVVCGYGDVGKGCAQALKGQGCIVYITEIDPI 336
            ||||.||||||.|:|||||.|||:||:|||||||||||||:|||||..|||..|.|||:||||||
Human   362 SVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPI 426

  Fly   337 CALQASMDGFRVVKLNEVIRNVDIVVTATGNKNVVVREHMDKMKSGCIVCNMGHSNTEIDVNGLR 401
            |||||.|||||:||||||||.||||:|.|||||||.|||:|:||:.|||||||||||||||..||
Human   427 CALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLR 491

  Fly   402 TPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLVNLSCSSIPSFAVSITSATQALALIELFNAPPG 466
            ||:||||:|||||||:|||:||.|:|||||||:|||||::|:|.:|||:.|||||||||:|||.|
Human   492 TPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEG 556

  Fly   467 RYKSDVYLLPKKMDEYVASLHLPTFDAHLTELSDEQAKYMGLNKAGPFKPNYYRY 521
            |||.||||||||||||||||||||||||||||:||||||:||||.||||||||||
Human   557 RYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL1	NP_647746.1	AdoHcyase	94..520	CDD:336064	344/425 (81%)
AHCYL2	NP_056143.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..184		44/145 (30%)
		LISN domain, inhibits interaction with ITPR1. /evidence=ECO:0000269\|PubMed:19220705	2..109		17/68 (25%)
		AdoHcyase	185..610	CDD:310083	344/425 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147783
Domainoid	1	1.000	282	1.000	Domainoid score	I1661
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I533
Isobase	1	0.950	-	0	Normalized mean entropy	S495
OMA	1	1.010	-	-		QHG48638
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	1	1.000	-	-		otm41371
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	LDO	PTHR23420
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5762
SonicParanoid	1	1.000	-	-		X2437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750