DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AhcyL1 and Ahcyl1

DIOPT Version :9

Sequence 1:	NP_647746.1	Gene:	AhcyL1 / 38342	FlyBaseID:	FBgn0035371	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_663517.2	Gene:	Ahcyl1 / 229709	MGIID:	2385184	Length:	530	Species:	Mus musculus

Alignment Length:	477	Identity:	370/477 - (77%)
Similarity:	418/477 - (87%)	Gaps:	4/477 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KKTSRYRSRSLSASSTDSFSS-ASYTGSSEDGDDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRR 109
            |...|..|||:|.|||||:|| ||||.||:  |:|.||||.|.||||||:|||:|| .|..||||
Mouse    57 KTGRRSLSRSISQSSTDSYSSAASYTDSSD--DEVSPREKQQTNSKGSSNFCVKNI-KQAEFGRR 118

  Fly   110 EIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINAQTAVLIETLVELGASVRWAACNIYSTQ 174
            |||||||:|..:|:|:|||..:|||..|||||||||.||||||||||..|||..||:||||||||
Mouse   119 EIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQ 183

  Fly   175 NEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNAENWQPNMILDDGGDATHLMLKKYPTMFKLV 239
            |||||||||:|:.:|||:||:|:|||||||||||.:.||.|||||||||.||.:.||||.:||.:
Mouse   184 NEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKI 248

  Fly   240 KGIVEESVTGVHRLYQLSKAGKLTVPAMNVNDSVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQ 304
            :||||||||||||||||||||||.||||||||||||.||||||.|:|||||.|||:|||||||||
Mouse   249 RGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQ 313

  Fly   305 VVVCGYGDVGKGCAQALKGQGCIVYITEIDPICALQASMDGFRVVKLNEVIRNVDIVVTATGNKN 369
            |||||||:|||||..|||..|.|||||||||||||||.||||||||||||||.||:|:|.|||||
Mouse   314 VVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKN 378

  Fly   370 VVVREHMDKMKSGCIVCNMGHSNTEIDVNGLRTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLV 434
            ||.|||:|:||:.|||||||||||||||..||||:||||:|||||||:|||:||.::|||||||:
Mouse   379 VVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLL 443

  Fly   435 NLSCSSIPSFAVSITSATQALALIELFNAPPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELS 499
            |||||::|:|.:|||:.|||||||||:|||.||||.|||||||||||||||||||:||||||||:
Mouse   444 NLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELT 508

  Fly   500 DEQAKYMGLNKAGPFKPNYYRY 521
            |:||||:||||.||||||||||
Mouse   509 DDQAKYLGLNKNGPFKPNYYRY 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL1	NP_647746.1	AdoHcyase	94..520	CDD:336064	335/425 (79%)
Ahcyl1	NP_663517.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..103		30/47 (64%)
		PEST. /evidence=ECO:0000269\|PubMed:12525476	65..92		18/28 (64%)
		AdoHcyase	106..529	CDD:214963	334/423 (79%)
		Interaction with BCL2L10. /evidence=ECO:0000250\|UniProtKB:O43865	138..201		47/62 (76%)
		NAD binding. /evidence=ECO:0000250	281..448		135/166 (81%)
		PDZ-binding	520..530		8/9 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837864
Domainoid	1	1.000	282	1.000	Domainoid score	I1644
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77353
Inparanoid	1	1.050	773	1.000	Inparanoid score	I531
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48638
OrthoDB	1	1.010	-	-		D371693at2759
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	1	1.000	-	-		otm43428
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5762
SonicParanoid	1	1.000	-	-		X2437
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800