Protein Alignment AhcyL1 and AHCYL1

DIOPT Version :10

• Sequence 1: NP_647746.1
• Gene: AhcyL1 / 38342
• FlyBaseID: FBgn0035371
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_006612.2
• Gene: AHCYL1 / 10768
• HGNCID: 344
• Length: 530
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 370/477 - (77%)
• Similarity: 418/477 - (87%)
• Gaps: 4/477 - (0%)

  Fly    46 KKTSRYRSRSLSASSTDSFSS-ASYTGSSEDGDDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRR 109
            |...|..|||:|.|||||:|| ||||.||:  |:|.||||.|.||||||:|||:|| .|..||||
Human    57 KTGRRSLSRSISQSSTDSYSSAASYTDSSD--DEVSPREKQQTNSKGSSNFCVKNI-KQAEFGRR 118

  Fly   110 EIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINAQTAVLIETLVELGASVRWAACNIYSTQ 174
            |||||||:|..:|:|:|||..:|||..|||||||||.||||||||||..|||..||:||||||||
Human   119 EIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQ 183

  Fly   175 NEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNAENWQPNMILDDGGDATHLMLKKYPTMFKLV 239
            |||||||||:|:.:|||:||:|:|||||||||||.:.||.|||||||||.||.:.||||.:||.:
Human   184 NEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKI 248

  Fly   240 KGIVEESVTGVHRLYQLSKAGKLTVPAMNVNDSVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQ 304
            :||||||||||||||||||||||.||||||||||||.||||||.|:|||||.|||:|||||||||
Human   249 RGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQ 313

  Fly   305 VVVCGYGDVGKGCAQALKGQGCIVYITEIDPICALQASMDGFRVVKLNEVIRNVDIVVTATGNKN 369
            |||||||:|||||..|||..|.|||||||||||||||.||||||||||||||.||:|:|.|||||
Human   314 VVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKN 378

  Fly   370 VVVREHMDKMKSGCIVCNMGHSNTEIDVNGLRTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLV 434
            ||.|||:|:||:.|||||||||||||||..||||:||||:|||||||:|||:||.::|||||||:
Human   379 VVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLL 443

  Fly   435 NLSCSSIPSFAVSITSATQALALIELFNAPPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELS 499
            |||||::|:|.:|||:.|||||||||:|||.||||.|||||||||||||||||||:||||||||:
Human   444 NLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELT 508

  Fly   500 DEQAKYMGLNKAGPFKPNYYRY 521
            |:||||:||||.||||||||||
Human   509 DDQAKYLGLNKNGPFKPNYYRY 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL1	NP_647746.1	AdoHcyase	96..520	CDD:214963	334/423 (79%)
AHCYL1	NP_006612.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..103		30/47 (64%)
		PEST. /evidence=ECO:0000269|PubMed:25237103	65..92		18/28 (64%)
		AdoHcyase	106..529	CDD:214963	334/423 (79%)
		Interaction with BCL2L10. /evidence=ECO:0000269|PubMed:27995898	138..201		47/62 (76%)
		NAD binding. /evidence=ECO:0000250	281..448		135/166 (81%)
		PDZ-binding. /evidence=ECO:0000250	520..530		8/9 (89%)