DRSC/TRiP Functional Genomics Resources

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Protein Alignment Non2 and SMARCD1

DIOPT Version :10

Sequence 1:NP_647745.1 Gene:Non2 / 38341 FlyBaseID:FBgn0035370 Length:244 Species:Drosophila melanogaster
Sequence 2:NP_003067.3 Gene:SMARCD1 / 6602 HGNCID:11106 Length:515 Species:Homo sapiens


Alignment Length:272 Identity:51/272 - (18%)
Similarity:85/272 - (31%) Gaps:112/272 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 GKDPDADPD------DESE----PSE----EEDPSSSEEEAAKKKKQSPKKRPQPTKHKAP---- 117
            |.:|...|.      |:|.    |.:    ::....:....|||||.:.|..||..:...|    
Human    82 GGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQA 146

  Fly   118 ------------------------------KKKRK-------TLNADDSGTESDAGSDSDYE--- 142
                                          |:|||       |.|...|..|...|:.:.:|   
Human   147 YMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAEDGEGTVASWELRV 211

  Fly   143 ---------VVKKPAAKKKAKAAG------------------------GTGSGRKSTGF------ 168
                     :.|..|.|:|.|.:.                        .|.:.:::.||      
Human   212 EGRLLEDSALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPG 276

  Fly   169 ---------------TRAYNLSPELSALMGESSLPRHEVVKKVWAIIKERDLYDPKNKQFAICDD 218
                           ...:.|.|.|:.|:|..:..|..:::.:|..||...|.||..::|.|||.
Human   277 DVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDK 341

  Fly   219 ELMKVMKIRRFR 230
            .|.::.:.:|.:
Human   342 YLQQIFESQRMK 353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Non2NP_647745.1 DEK_C 5..57 CDD:462592
SWIB-MDM2_like 172..242 CDD:349489 18/59 (31%)
SMARCD1NP_003067.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..103 5/20 (25%)
Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342 43..167 15/84 (18%)
Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342 168..474 36/186 (19%)
Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo 180..515 34/174 (20%)
SWIB_BAF60A 294..370 CDD:349493 18/60 (30%)
Blue background indicates that the domain is not in the aligned region.

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