Protein Alignment Mrtf and MYOCD

DIOPT Version :10

• Sequence 1: NP_001137879.3
• Gene: Mrtf / 38338
• FlyBaseID: FBgn0052296
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: NP_001139784.1
• Gene: MYOCD / 93649
• HGNCID: 16067
• Length: 986
• Species: Homo sapiens
• Alignment Length: 1357
• Identity: 280/1357 - (20%)
• Similarity: 439/1357 - (32%)
• Gaps: 551/1357 - (40%)

  Fly   340 KNKESLKVKLMVRRPHSQLVEQGIIPSLKTSPAIHEQCKQLERAKTSDLLKAKIQQRPNREDLER 404
            |.:..|:::|..||...||..|||||.||.....|||.|.|:..|..:.||.|.:.|.|..||..
Human    15 KFRSVLQLRLQQRRTQEQLANQGIIPPLKRPAEFHEQRKHLDSDKAKNSLKRKARNRCNSADLVN 79

  Fly   405 LHILEEDECHIDPSLAEKQRMLKKARLADQLNSQIQHRPGPLELIKKNILHTEKPIEKIVKEGLV 469
            :|||:....  :.|:...|..||:|||||.||.:|..|||||||::||||..:..:::.:|...|
Human    80 MHILQASTA--ERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPVDSAVKEAIKGNQV 142

  Fly   470 SFKATSEGLLTRPQHPHSYVTFDDDSLS---SESDTRQTPPRLDEAMVATSSSPTDVLQAAAASA 531
            ||..:::..           .|::||.|   |...||...|:      .::.||.|    |.||
Human   143 SFSKSTDAF-----------AFEEDSSSDGLSPDQTRSEDPQ------NSAGSPPD----AKAS- 185

  Fly   532 GIVTMALTMPTAGQLVVTSPQILPQQQQPKAIVVPAPVPPPPPPPPPLPMASIIKVKQETANLYE 596
                   ..|:.|.|
Human   186 -------DTPSTGSL-------------------------------------------------- 193

  Fly   597 ELCQSVTGTTASPVNHLYSPCSLASSTSTLSPLSSIASPPP-----------PPMTTTRLHLAPV 650
                   ||..          .|||.:.  :..:..||.|.           ||.|...:|.|
Human   194 -------GTNQ----------DLASGSE--NDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAA-- 237

  Fly   651 SVKSDAPGKDKNRKKSKSKPVSKARTIKFHEYKGPPSAAGQKQDQTQPEETSYQLMLEQQNCLLK 715
             |||.:.|..|||.|....|..|.:.:|:|:|. ||....:|  ...|.:::|..:|:||...|:
Human   238 -VKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYI-PPDQKAEK--SPPPMDSAYARLLQQQQLFLQ 298

  Fly   716 FLENLNKNQSIIPAPSAPGVMLPAAPGATNNSITVTTKTVPALASQSAPAPAPISLPNTISITSS 780
            .
Human   299 L---------------------------------------------------------------- 299

  Fly   781 SGGAPLNFGDATMLTPTPAATPTPPTLSLIAAPQQQLQLHQ-----QHQ-QLHQP---------- 829
                                        .|.:.|||.|.|:     .|| ||.:|
Human   300 ----------------------------QILSQQQQQQQHRFSYLGMHQAQLKEPNEQMVRNPNS 336

  Fly   830 --TPVQHPPPLP-----SPALSVSSSIP-PSPATSYAESTTSSITDLARLEKMKVSDLKQHLKRR 886
              ||:.:.|..|     |....|||..| |.|               ..|:.:|||:|:|.|:.|
Human   337 SSTPLSNTPLSPVKNSFSGQTGVSSFKPGPLP---------------PNLDDLKVSELRQQLRIR 386

  Fly   887 NLPVSGPKPHLIERLKPYLPLEPLDSNVTPAPTSNN---------SNTTPEVITISDAMDTSN-- 940
            .|||||.|..|::||:|:     .|.:..|.|...:         .||.|...:.|.....||
Human   387 GLPVSGTKTALMDRLRPF-----QDCSGNPVPNFGDITTVTFPVTPNTLPNYQSSSSTSALSNGF 446

  Fly   941 --CGLLEQPPPVTMLVSDASMEHEQMDVVQQQMDN--THPMTLQTILPPQPQTATIILTN----- 996
              .|.....||::...||.|:.....|.......:  .||.      |....|...::::
Human   447 YHFGSTSSSPPISPASSDLSVAGSLPDTFNDASPSFGLHPS------PVHVCTEESLMSSLNGGS 505

  Fly   997 ------------EELLREQQRKIDELQRQLQRSQQELQKIRQRQQQQQHQQQQTVTAQVVNALPS 1049
                        :::|.|:|:.|:||..:||:.|::::::|.:.|:|:
Human   506 VPSELDGLDSEKDKMLVEKQKVINELTWKLQQEQRQVEELRMQLQKQK----------------- 553

  Fly  1050 QQITLITTTSNGPQQTLTVMPQQVEKNFPAKVTVKATGGNSNHKVNGLQQQGSAAKKPASSNSNS 1114
                                                                             
Human   554 ----------------------------------------------------------------- 553

  Fly  1115 NSNISSSNPPPINQKMVVKQQLEAKIQKQKAAAAAA-AQQQQQQQQQQQQQQQQQALQQQQQQQQ 1178
            .:|.|...|.|.         |.|.|::::|.::.. |.|...::|....:....|.:..|.|
Human   554 RNNCSEKKPLPF---------LAASIKQEEAVSSCPFASQVPVKRQSSSSECHPPACEAAQLQ-- 607

  Fly  1179 QQQQVRLLTQKTQTVFIPFNNNNHINNASAKTTTKKSNVPANNTNTTTATMMQ-----------A 1232
                             |..|.:.:.:             ::.||..::|.:.           |
Human   608 -----------------PLGNAHCVES-------------SDQTNVLSSTFLSPQCSPQHSPLGA 642

  Fly  1233 AKPAAVAAAAASPGNQHHNNLGLLWNEGNQTILLLGLNDQHMTAHTLGNISLTATTTTT--AAPP 1295
            .|.....:...||.|.|.    |..:.|.|       .:.|..:..:.:...||..:..  ..||
Human   643 VKSPQHISLPPSPNNPHF----LPSSSGAQ-------GEGHRVSSPISSQVCTAQNSGAHDGHPP 696

  Fly  1296 AATPVAASTIAPPKKILNGHQRTNSLPSIVFPIETKSIITQQQLQQLQQQQQQQQQF---QPVQQ 1357
            :.:| .:|::.||   .:|.|..:|..:...|. .||...||::..|....:...:|   .|...
Human   697 SFSP-HSSSLHPP---FSGAQADSSHGAGGNPC-PKSPCVQQKMAGLHSSDKVGPKFSIPSPTFS 756

  Fly  1358 PKQQQLNQVDIKPAPAPPPQYEEATKQLAASKAAALNGLLPLVKIKEEPVQSPAPSAAPLPQTAP 1422
            .....:::|      ..||.||:|.||
Human   757 KSSSAISEV------TQPPSYEDAVKQ-------------------------------------- 777

  Fly  1423 LCKRKTASIKSEQVSDVLDILIKQGELPESAALEPITPLTPLPELSMFNGATPTTA--------- 1478
                  ...:|:|:.::||:||:.||:|..|. |..:.|..:|::.. :..:||..
Human   778 ------QMTRSQQMDELLDVLIESGEMPADAR-EDHSCLQKVPKIPR-SSRSPTAVLTKPSASFE 834

  Fly  1479 -AGGASIVPLVP-------KLETPVTPVQNLDVAMDTNVQHV------------GFASNQAPN-- 1521
             |...|.:|..|       .||..:.....|....|..:..:            ||:...|.:
Human   835 QASSGSQIPFDPYATDSDEHLEVLLNSQSPLGKMSDVTLLKIGSEEPHFDGIMDGFSGKAAEDLF 899

  Fly  1522 --HVFIESIDMASPLQT--DSSAIDA--------ESVAKTLDIFLEQHHATPPPSTP 1566
              |..:..  ..||:||  ..|::|:        ||..:|:: :|:   .|||.|||
Human   900 NAHEILPG--PLSPMQTQFSPSSVDSNGLQLSFTESPWETME-WLD---LTPPNSTP 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrtf	NP_001137879.3	RPEL	387..412	CDD:128947	10/24 (42%)
		RPEL	433..458	CDD:128947	15/24 (63%)
		SAP	871..905	CDD:460424	18/33 (55%)
MYOCD	NP_001139784.1	RPEL	106..131	CDD:128947	15/24 (63%)
		SAP	371..404	CDD:460424	17/32 (53%)