DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrtf and MRTFA

DIOPT Version :9

Sequence 1:	NP_001137879.3	Gene:	Mrtf / 38338	FlyBaseID:	FBgn0052296	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_065882.2	Gene:	MRTFA / 57591	HGNCID:	14334	Length:	1031	Species:	Homo sapiens

Alignment Length:	1362	Identity:	322/1362 - (23%)
Similarity:	461/1362 - (33%)	Gaps:	531/1362 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 SPLQPAMDKNKESLKVKLMVRRPHSQLVEQGIIPSLKTSPAIHEQCKQLERAKTSDLLKAKIQQR 396
            :|..|.:.:.|..|::||..||...:||.|||:|.||:..|.|||.:.||||:|.|.||.||:.|
Human    69 NPNLPPLSERKNVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSR 133

  Fly   397 PNREDLERLHILEEDECHIDPSLAEKQRMLKKARLADQLNSQIQHRPGPLELIKKNILHTEKPIE 461
            |.|.:|.|:|||||...  :|||..||..||:|||||.||.:|..||||:||::||||    |:|
Human   134 PERSELVRMHILEETSA--EPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNIL----PVE 192

  Fly   462 KIVKEGLV-------------SFKATSEGLLTRPQHPHSYVTFDDDSLSSESDTRQTPPRLDEAM 513
            ..:||.::             ||...|...|: |:.|.|:.:  ..|:.|..:.|.:.|.|.
Human   193 SSLKEAIIVGQVNYPKVADSSSFDEDSSDALS-PEQPASHES--QGSVPSPLEARVSEPLLS--- 251

  Fly   514 VATSSSPTDVLQAAAASAGIVTMALTMPTAGQLVVTSPQILPQQQQPKAIVVPAPVPPPPPPP-- 576
             |||:|||.|:..                           ||..:..:.::..|..||.||||
Human   252 -ATSASPTQVVSQ---------------------------LPMGRDSREMLFLAEQPPLPPPPLL 288

  Fly   577 PPLPMASIIKVKQETANLYEELCQSVTGTTASPVNHLYSPCSLASSTSTLSPLSSIASPPPPPMT 641
            ||                      |:|..|..|.         |.||.||
Human   289 PP----------------------SLTNGTTIPT---------AKSTPTL--------------- 307

  Fly   642 TTRLHLAPVSVKSDAP--GKDKNRKKSKSKPVS-KARTIKFHEYKGPPSAAGQKQDQ-TQPEETS 702
                      :|...|  ..:|:::..|:|.:. |.:.:|:|:|. ||.   ||||: ..|.::|
Human   308 ----------IKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYI-PPD---QKQDRGAPPMDSS 358

  Fly   703 YQLMLEQQNCLLKFLENLNKN-------QSIIPAPSAPGVMLPAAPGATNNSITVTTKTVPALAS 760
            |..:|:||...|: |:.||:.       |:|:|||       |.:.|             .||.|
Human   359 YAKILQQQQLFLQ-LQILNQQQQQHHNYQAILPAP-------PKSAG-------------EALGS 402

  Fly   761 QSAPAPAPISLPNTISITSSSGGAPLNFG----DATMLTPTPAATPTPPTLSLIAAPQQQLQLHQ 821
            ...|....:|..|    :|||.|||...|    ::|.||..|.|.|
Human   403 SGTPPVRSLSTTN----SSSSSGAPGPCGLARQNSTSLTGKPGALP------------------- 444

  Fly   822 QHQQLHQPTPVQHPPPLPSPALSVSSSIPPSPATSYAESTTSSITDLARLEKMKVSDLKQHLKRR 886
                                                           |.|:.|||::|||.||.|
Human   445 -----------------------------------------------ANLDDMKVAELKQELKLR 462

  Fly   887 NLPVSGPKPHLIERLKPYLPLEPLDSNVTPAPTSNNSNTTPEVITISDAMDTSNCGLLEQPPPVT 951
            :|||||.|..|||||:.|      ...::|.|.:
Human   463 SLPVSGTKTELIERLRAY------QDQISPVPGA------------------------------- 490

  Fly   952 MLVSDASMEHEQMDVVQQQMDNTHPMTLQTILPPQPQTATIILTNEELLREQQRKIDELQRQLQR 1016
                                             |:...||.||
Human   491 ---------------------------------PKAPAATSIL---------------------- 500

  Fly  1017 SQQELQKIRQRQQQQQHQQQQTVTAQVVNALPSQQITLITTTSNGPQQTLTVMPQQVEKNFPAKV 1081
                            |:     ..:||.|.|:.::      |.||......:.       ||:|
Human   501 ----------------HK-----AGEVVVAFPAARL------STGPALVAAGLA-------PAEV 531

  Fly  1082 TVKATGGNSNHKVNGLQQQGSAAKKPASSNSNSNSNISS-----SNP---------PPINQKMVV 1132
            .| ||..:|     |:.:.||....|..|.:.|..::.|     |.|         .|:.|..:.
Human   532 VV-ATVASS-----GVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQ 590

  Fly  1133 KQQLEAKIQKQKAAAA---------AAAQQQQQQQQQQQQQQQQQALQQQQQQQQQQQQVRLLTQ 1188
            ...|:..::::...|.         |..:.:.:.|..|::.:|.:||.:..:|:||..: ||..|
Human   591 ASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVE-RLKLQ 654

  Fly  1189 KTQTVFIPFNNNNHINNASAKTTTKKSNVPANNTNTTTATMMQAAKPAAVAAAAASPGNQHHNNL 1253
            ..|.                                     .:|.:||...|...:|..|.::
Human   655 LEQE-------------------------------------KRAQQPAPAPAPLGTPVKQENS-- 680

  Fly  1254 GLLWNEGNQTILLLGLNDQHMTAHTLG-----NISLTATTTTTAAPPAATPVAASTI-------- 1305
                           .:...::...||     |.||.|..|....|.|..|...|.:
Human   681 ---------------FSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQP 730

  Fly  1306 ----APPKKILNGHQRTNSLPSIVFPIETKSIITQQQLQQLQQQQQQQQQFQP------VQQPKQ 1360
                .|..::|.|.|.    ||::..:...::||......|......:....|      .|||..
Human   731 EPEPVPAPQLLLGPQG----PSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSS 791

  Fly  1361 QQLNQVDIKPAPAPPPQ--YEEATKQLAASKAAALNGLLPLVKIKEEPVQSPAPSAAPLPQTAPL 1423
            |..:     |||||..|  .|...:.|..:..:.|.        ||.|....|.|..|
Human   792 QPGS-----PAPAPSAQMDLEHPLQPLFGTPTSLLK--------KEPPGYEEAMSQQP------- 836

  Fly  1424 CKRKTASIKSEQVSDVLDILIKQGELPESAALEPITPLTPLPELSMFNGATPTTAAGGASIVPLV 1488
             |::.....|:|:.|:.||||:.||:.......|..|....|        :|.|..|........
Human   837 -KQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKP--------SPKTVCGSPLAAQPS 892

  Fly  1489 PKLETP-VTPVQNLDVAMDTNVQHVGFASNQAPNHV--FIESIDMASPLQTDS-------SAIDA 1543
            |..|.| ..|...              .|...|..:  |:|| ....||.|..       |.||
Human   893 PSAELPQAAPPPP--------------GSPSLPGRLEDFLES-STGLPLLTSGHDGPEPLSLID- 941

  Fly  1544 ESVAKTLDIFLEQHHAT-----PPPSTPPKSCHSGSEKPNSP---DAKLNHFDEYELLELMS 1597
                   |:..:...:|     ||........|...| |:|.   |....|.|..:.|||.|
Human   942 -------DLHSQMLSSTAILDHPPSPMDTSELHFVPE-PSSTMGLDLADGHLDSMDWLELSS 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrtf	NP_001137879.3	RPEL	387..412	CDD:128947	15/24 (63%)
		RPEL	433..458	CDD:128947	14/24 (58%)
		SAP	871..905	CDD:280251	21/33 (64%)
MRTFA	NP_065882.2	RPEL	81..105	CDD:128947	11/23 (48%)
		RPEL	124..149	CDD:128947	15/24 (63%)
		RPEL	168..193	CDD:128947	15/28 (54%)
		Rho	433..>575	CDD:333130	60/339 (18%)
		SAP	447..480	CDD:307935	21/32 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146967
Domainoid	1	1.000	49	1.000	Domainoid score	I11803
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3763
Isobase	1	0.950	-	0	Normalized mean entropy	S8133
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001082
OrthoInspector	1	1.000	-	-		otm41022
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22793
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2343
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.030