DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrtf and mrtfbb

DIOPT Version :9

Sequence 1:	NP_001137879.3	Gene:	Mrtf / 38338	FlyBaseID:	FBgn0052296	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	XP_009298015.1	Gene:	mrtfbb / 557356	ZFINID:	ZDB-GENE-030619-16	Length:	926	Species:	Danio rerio

Alignment Length:	1302	Identity:	298/1302 - (22%)
Similarity:	469/1302 - (36%)	Gaps:	527/1302 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 PLQ--PAMDKNKESLKVKLMVRRPHSQLVEQGIIPSLKTSPAIHEQCKQLERAKTSDLLKAKIQQ 395
            |.|  |.:.:.|..|:::|..||...||.:|||:|.|||..|.|||.:.||||:|.:.||.||:.
Zfish    39 PTQSLPPIKERKNVLQLRLQQRRTREQLADQGIMPPLKTPAAFHEQVRSLERARTENFLKHKIRS 103

  Fly   396 RPNREDLERLHILEEDECHIDPSLAEKQRMLKKARLADQLNSQIQHRPGPLELIKKNILHTEKPI 460
            ||:|.:|.|:|||:  |.|.:|||...|..||:|||||.||.:|..||||:||::||||    |:
Zfish   104 RPDRAELVRMHILQ--ETHAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNIL----PV 162

  Fly   461 EKIVKEGLVSFKATSEGLLTRPQHPHSYVTFDDDSLSSESDTRQTP--PRLDEAMVATSSSPTDV 523
            : ||.|                        .||.:.:.:|....:|  |...|:. .::|||.:.
Zfish   163 D-IVDE------------------------VDDCNFNDDSSEALSPDQPASHESQ-CSASSPVET 201

  Fly   524 LQAAAASAGIVTMALTMPTAGQLVVTSPQILPQQQQPKAIVVPAPVPPPPPPPPPLPMASIIKVK 588
            .                             ||..         :.|.||          ::.|::
Zfish   202 R-----------------------------LPDS---------SSVSPP----------TVSKLQ 218

  Fly   589 QETANLYEELCQSVTGTTASPVNHLYSPCSLASSTSTLSPLSSIASPPPPPMTTTRLHLAPVSVK 653
                      |..:...|::..:.:     ..::|.|:     ||:.|..|        .|..||
Zfish   219 ----------CSDILNRTSAEDSRI-----KMNATQTV-----IAAVPTRP--------GPTLVK 255

  Fly   654 SDAP--GKDKNRKKSKSKPVSKARTIKFHEYKGPPSAAGQKQDQTQ-PEETSYQLMLEQQNCLLK 715
            ...|  ..||:|.|...:|..:.:.:|:|:|. ||.   |||:..: |.::||..:|:||...|:
Zfish   256 QSQPKLSSDKSRSKKSKEPKPRIKKLKYHQYI-PPD---QKQEPNEAPMDSSYARLLQQQQQFLQ 316

  Fly   716 FLENLNKN------QSIIPAPSAPGVMLPAAPGATNNSITVTTKTVPALASQSAPAPAPISLPNT 774
             |:.|::.      |:|:|||      |.....:.|:...:|..|.|.|     |||..:|||:.
Zfish   317 -LQILSQQQQHYNYQAILPAP------LKQVAESPNSCPNITLSTSPNL-----PAPIVVSLPSV 369

  Fly   775 ISITSSSGGAPLNFGDATMLTPTPAATPTPPTLSLIAAPQQQLQLHQQHQQLHQPTPVQHPPPLP 839
                                                                        .|..|
Zfish   370 ------------------------------------------------------------APSRP 374

  Fly   840 SPALSVSSSIPPSPATSYAESTTSSITDLARLEKMKVSDLKQHLKRRNLPVSGPKPHLIERLKPY 904
            :.|.. |.|:|                  :.|::|||::||..||.|.|||||.|..||||||.:
Zfish   375 NNARK-SGSLP------------------SCLDEMKVAELKAELKLRGLPVSGTKIDLIERLKAH 420

  Fly   905 L-PLEPLDSNVTPAPTSNNSNTTPEVITISDAMDTSNCGLLEQPPPVTMLVSDASMEHEQMDVVQ 968
            . ..:.:|:|::.|.            .:.|:|.|:        |||:...|:.|||..:....:
Zfish   421 QESSQAMDTNISKAS------------LLPDSMSTT--------PPVSPEASNVSMEDSRDSPTK 465

  Fly   969 QQMDNTHPMTLQTILPPQPQ--TATIILTNEEL----------LREQQRKIDELQRQLQRSQQEL 1021
            .|.         .:.|.||.  |:...|.:|::          |.|::|:|:||.|:|::.|:.:
Zfish   466 AQC---------RLSPAQPPGGTSPFKLVSEDMDIKVSEKDQRLHEKERQIEELMRKLEQEQRLV 521

  Fly  1022 QKIRQRQQQQQHQQQQTVTAQVVNALPSQQITLITTTSNGPQQTLTVMPQQVEKNFPAKVTVKAT 1086
            ::::                                           |..:|||.         :
Zfish   522 EELK-------------------------------------------MQLEVEKR---------S 534

  Fly  1087 GGNSNHKVNGLQQQGSAAKKPASSNSNSNSNISSSNPPPINQKMVVKQQLEA--KIQKQKAAAAA 1149
            ||:                              .:.|.|:.|   ||:::.|  .....::..|.
Zfish   535 GGH------------------------------QAEPCPLVQ---VKEEIGASPSCNSGQSLQAP 566

  Fly  1150 AAQQQQQQQQQQQQQQQQQALQQQQQQQQQQQQVRLLTQKTQTVFIPFNNNNHINNASAKTTTKK 1214
            ..:|::...|....|.||..::.||..|...||..:..|....:.:|.
Zfish   567 GVKQEEPHTQMAHAQVQQFYIKTQQVPQVLHQQALISPQSASQILLPI----------------- 614

  Fly  1215 SNVPANNTNTTTATMMQAAKPAAVAAAAASPGNQHHNNLGLLWNEGNQTILLLGLNDQHMTAHTL 1279
             ::|:|..:|...|::|:...|              .::|       ||.||        ...|.
Zfish   615 -SLPSNPMSTQAPTILQSTSLA--------------QSIG-------QTPLL--------QTQTS 649

  Fly  1280 GNISLTATTTTTAAPPAATPVAAST----------------------IAPPKKILNGHQRTNSLP 1322
            .|..|...:..|.:||.|.|:...:                      ::|.....|||  .|:.|
Zfish   650 NNAMLQQHSNQTPSPPHALPLCGGSPSGFEYRQNQNQPQCFINNSPRVSPRHTTPNGH--INNPP 712

  Fly  1323 SIVFPIETKSIITQQQLQQLQQQQQQQQQFQPVQQPKQQQLNQVDIKPAPAPPPQYEEATKQLAA 1387
            |   |.:...|:                  ||...|...       .|....||.||||.||...
Zfish   713 S---PCQLNYIL------------------QPSSFPNHH-------SPKSKDPPGYEEAVKQTRG 749

  Fly  1388 SKAAALNGLLPLVKIKEEPVQSPAPSAAPLPQTAPLCKRKTASIKSEQVSDVLDILIKQGELP-- 1450
            .:|.               :|.|                 ||:  |:.:.|:.|:||:.||:|
Zfish   750 LQAT---------------MQVP-----------------TAT--SQHMDDLFDVLIESGEIPPL 780

  Fly  1451 --ESAALEPITPLTPLPELSMFNGATPTTAAGGASIVPLVPKLETPVTPVQNLDVAMDTNVQHVG 1513
              :..:|:.:.|:|          |..||       :|:...|..|  |.| :.||...|..||
Zfish   781 SRQDPSLDKLHPVT----------ANITT-------LPINTVLSRP--PPQ-VHVARPPNQTHV- 824

  Fly  1514 FASNQAPNHVFIESIDMASPLQTDSSAIDAESVAKTLDIFLEQHHATPPPSTPPKSCHSGSEKPN 1578
                 :|    :..:.:||..|.::...|||  .:||.:..|..:..             .|:|:
Zfish   825 -----SP----LSLVALASDNQLEALLEDAE--PRTLRLMEELKNQL-------------LERPH 865

  Fly  1579 SP 1580
            ||
Zfish   866 SP 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrtf	NP_001137879.3	RPEL	387..412	CDD:128947	12/24 (50%)
		RPEL	433..458	CDD:128947	14/24 (58%)
		SAP	871..905	CDD:280251	21/33 (64%)
mrtfbb	XP_009298015.1	RPEL	97..118	CDD:280851	12/22 (55%)
		RPEL	139..163	CDD:128947	15/27 (56%)
		SAP	387..420	CDD:280251	21/32 (66%)
		DUF2130	492..>531	CDD:286935	10/81 (12%)
		TFIIA	573..>762	CDD:281188	56/299 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580435
Domainoid	1	1.000	46	1.000	Domainoid score	I12103
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3905
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001082
OrthoInspector	1	1.000	-	-		otm24647
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4963
SonicParanoid	1	1.000	-	-		X2343
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.020