DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrtf and Mrtfa

DIOPT Version :9

Sequence 1:	NP_001137879.3	Gene:	Mrtf / 38338	FlyBaseID:	FBgn0052296	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	XP_038936213.1	Gene:	Mrtfa / 315151	RGDID:	1304873	Length:	1079	Species:	Rattus norvegicus

Alignment Length:	1506	Identity:	343/1506 - (22%)
Similarity:	517/1506 - (34%)	Gaps:	616/1506 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 SLHSLSSGSSGSSSGNSASGSSSLLATISTSPLTTVELISSAACSGLLATRLSGKDLEHSFQDII 285
            :::.|..|.:|.:.      ...:|.::|.:|....|.::                  :..|::.
  Rat    25 AVNGLDGGGAGEND------EEPVLLSLSAAPSPQSEAVA------------------NELQELS 65

  Fly   286 L-------LHEAYD----DMSEGEQRLHATFLGSSDDG--NNSDCYDARQSPPKAIVDSSPLQPA 337
            |       ||...:    .:||.:..|....:.|.:.|  :|.......||....:|..|....|
  Rat    66 LQPELTLGLHPGRNPNLPPLSERKNGLQHGDIYSCEGGLTSNQKVVSFSQSNRGTVVPGSTSCLA 130

  Fly   338 MDKNKESLKVKLMVRRPHSQLVEQGIIPSLKTSPAIHEQCKQLERAKTSDLLKAKIQQRPNREDL 402
                 ..|::||..||...:||.|||:|.||:..|.|||.:.||||:|.|.||.||:.||.|.:|
  Rat   131 -----AVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSEL 190

  Fly   403 ERLHILEEDECHIDPSLAEKQRMLKKARLADQLNSQIQHRPGPLELIKKNILHTEKPIEKIVKEG 467
            .|:|||||...  :|||..||..||:|||||.||.:|..||||:||::||||    |:|..:||.
  Rat   191 VRMHILEETSA--EPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNIL----PVESSLKEA 249

  Fly   468 LV-------------SFKATSEGLLTRPQHPHSYVTFDDDSLSSESDTRQTPPRLDEAMVATSSS 519
            |:             ||...|...|: |:.|.|:.:  ..|:.|..::|.:    |....|||.|
  Rat   250 LIVGQVNYPKVADSSSFDEDSSDALS-PEQPASHES--QGSVPSPLESRAS----DLLPSATSIS 307

  Fly   520 PTDVLQAAAASAGIVTMALTMPTAGQLVVTSPQILPQQQQPKAIVVPAPVPPPPPPPPPLPMASI 584
            ||.||..       :.||   |..|:.:..:       :||       |:||||..||.|...||
  Rat   308 PTQVLSQ-------LPMA---PDPGETLFLA-------EQP-------PLPPPPLLPPSLTSGSI 348

  Fly   585 IKVKQETANLYEELCQSVTGTTASPVNHLYSPCSLASSTSTLSPLSSIASPPPPPMTTTRLHLAP 649
            :                   .||.|                                      ||
  Rat   349 V-------------------PTAKP--------------------------------------AP 356

  Fly   650 VSVKSDAP--GKDKNRKKSKSKPVS-KARTIKFHEYKGPPSAAGQKQDQTQPE-ETSYQLMLEQQ 710
            ..:|...|  ..:|:::..|:|.:. |.:.:|:|:|. ||.   ||||:..|. ::||..:|:||
  Rat   357 TLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYI-PPD---QKQDKGAPAMDSSYAKILQQQ 417

  Fly   711 NCLLKFLENLNKN-----------QSIIPAPSAPGVMLPAAPGATNNSITVTTKTVPALASQSAP 764
            ...|: |:.||:.           |:|:|||..|.       |.|..|              |||
  Rat   418 QLFLQ-LQILNQQQQQQQQQHYNYQAILPAPPKPS-------GETPGS--------------SAP 460

  Fly   765 APAPISLPNTISITSSSGGAPLNFGDATMLTPTPAATPTPPTLSLIAAPQQQLQLHQQHQQLHQP 829
            .|:     .::|.:|||...          ||.|.......:.:|...|
  Rat   461 TPS-----RSLSTSSSSSSG----------TPGPGGLARQNSTALAGKP---------------- 494

  Fly   830 TPVQHPPPLPSPALSVSSSIPPSPATSYAESTTSSITDLARLEKMKVSDLKQHLKRRNLPVSGPK 894
                             .::|                  |.|:.|||::|||.||.|:|||||.|
  Rat   495 -----------------GALP------------------ANLDDMKVAELKQELKLRSLPVSGTK 524

  Fly   895 PHLIERLKPYLPLEPLDSNVTPAPTSNNSNTTPEVITISD------------------------- 934
            ..|||||:.|      ...|:|||.:..:..|..|::.:.
  Rat   525 TELIERLRAY------QDQVSPAPGAPKAPATTSVLSKAGEVVVAFPAALLSTGSALVTAGLAPA 583

  Fly   935 ----AMDTSNCGLLE-----QPPPVTMLVSDASM------EHEQMDVVQQQMDNTHPMTLQTI-- 982
                |..||| |:::     ..|||:...|:.|:      .....|...:.:  |.|:|..|:
  Rat   584 EMVVATVTSN-GMVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDAFGEMV--TSPLTQLTLQA 645

  Fly   983 -----------------LPPQPQTATIILTNEELLREQQRKIDELQRQLQRSQQELQKIRQRQQQ 1030
                             |.|..:.....|..:::|:|:.::|:||.|.||:.||.::.:|.:.:|
  Rat   646 SPLQIVKEEGARAASCCLSPGARAELEGLDKDQMLQEKDKQIEELTRMLQQKQQLVELLRLQLEQ 710

  Fly  1031 QQHQQQQTVTAQVVNALPSQQITLITTTSNGPQQTLTVMPQQVEKNFPAKVTVKATGGNSNHKVN 1095
            |:..||           |:...:.:...|:.....|:..||...:.|...:.|..|    ||
  Rat   711 QKRAQQ-----------PAPASSPVKRESSFSSCQLSCQPQGAARAFGPGLVVPTT----NH--- 757

  Fly  1096 GLQQQGSAAKKPASSNSNSNSNISSSNPPPINQKMVVKQQLEAKIQKQKAAAAAAAQQQQQQQQQ 1160
                  ..|:.||..:            ||:    ||||  ||...:...|.|:
  Rat   758 ------GDAQAPAPES------------PPV----VVKQ--EAGPPEPDLAPAS----------- 787

  Fly  1161 QQQQQQQQALQQQQQQQQQQQQVRLLTQKTQTVFIPFNNNNHINNASAKTTTKKSNVPANNTNTT 1225
                                   :||.....|.|:                 ||.:.|...|::|
  Rat   788 -----------------------QLLLGSQGTSFL-----------------KKVSPPTLVTDST 812

  Fly  1226 TATMMQAAKPAAVAAAAASPGNQHHNNLGLLWNEGNQTILLLGLNDQHMTAHTLGNISLTATTTT 1290
                                              |...|                   ||.|..:
  Rat   813 ----------------------------------GTHLI-------------------LTVTNKS 824

  Fly  1291 TAAP--PAATPVAASTIAPPKKILNGHQRTNSLPSIVFPIETKSIITQQQLQQLQQQQQQQQQFQ 1353
            ...|  |..:|.                                                    |
  Rat   825 ADGPGLPTGSPQ----------------------------------------------------Q 837

  Fly  1354 PVQQPKQQQLNQVDIKPAPAPPPQYE-EATKQLAASKAAALNGLLPLVKIKEEP-------VQSP 1410
            |:.||.         .|||.||.|.: |...|.:.:...:|        :|:||       .|.|
  Rat   838 PLSQPG---------SPAPGPPAQMDLEHPPQPSFATPTSL--------LKKEPPGYEETVTQQP 885

  Fly  1411 APSAAPLPQTAPLCKRKTASIKSEQVSDVLDILIKQGEL----------------PESAALEPIT 1459
                          |::.....|:.:.|:.||||:.||:                |.:.|..|
  Rat   886 --------------KQQENGSSSQHMDDLFDILIQSGEISADFKEPPSLPGKEKSPPAEAYGP-- 934

  Fly  1460 PLTPLPE-LSMFNGATPTTAAGGASIVPLVP-KLETPVTPVQNLDVAMDTNVQHVGFASNQAPNH 1522
            ||||.|. ||....|.|...:      |.:| :||..:.....|.:..         :.::.|..
  Rat   935 PLTPQPSPLSELPQAAPPPGS------PTLPGRLEDFLESSTGLPLLT---------SGHEGPEP 984

  Fly  1523 VFIESIDMASPLQTDSSAID-AESVAKTLDIFLEQHHATPPPSTPPKSCHSGSEKPNSPDAKLNH 1586
            :.:.. |:.|.:.:.|:.:| ..|...|.::     |..|.||       ||.    ..|..:.|
  Rat   985 LSLID-DLHSQMLSSSAILDHPPSPMDTSEL-----HFAPEPS-------SGM----GLDLAVGH 1032

  Fly  1587 FDEYELLELMS 1597
            .|..:.|||.|
  Rat  1033 LDSMDWLELSS 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrtf	NP_001137879.3	RPEL	387..412	CDD:128947	15/24 (63%)
		RPEL	433..458	CDD:128947	14/24 (58%)
		SAP	871..905	CDD:280251	21/33 (64%)
Mrtfa	XP_038936213.1	RPEL	131..156	CDD:128947	11/24 (46%)
		RPEL	175..200	CDD:128947	15/24 (63%)
		RPEL	219..244	CDD:128947	15/28 (54%)
		SAP	501..534	CDD:396567	21/32 (66%)
		PHA03247	<709..961	CDD:223021	85/488 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340630
Domainoid	1	1.000	44	1.000	Domainoid score	I11978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3731
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001082
OrthoInspector	1	1.000	-	-		otm45158
orthoMCL	1	0.900	-	-		OOG6_104701
Panther	1	1.100	-	-	LDO	PTHR22793
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2343
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980