DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrtf and Mrtfa

DIOPT Version :9

Sequence 1:	NP_001137879.3	Gene:	Mrtf / 38338	FlyBaseID:	FBgn0052296	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_001076005.2	Gene:	Mrtfa / 223701	MGIID:	2384495	Length:	1029	Species:	Mus musculus

Alignment Length:	1356	Identity:	324/1356 - (23%)
Similarity:	474/1356 - (34%)	Gaps:	521/1356 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 SPLQPAMDKNKESLKVKLMVRRPHSQLVEQGIIPSLKTSPAIHEQCKQLERAKTSDLLKAKIQQR 396
            :|..|.:.:.|..|::||..||...:||.|||:|.||:..|.|||.:.||||:|.|.||.||:.|
Mouse    69 NPNLPPLSERKNVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSR 133

  Fly   397 PNREDLERLHILEEDECHIDPSLAEKQRMLKKARLADQLNSQIQHRPGPLELIKKNILHTEKPIE 461
            |.|.:|.|:|||||...  :|||..||..||:|||||.||.:|..||||:||::||||    |:|
Mouse   134 PERAELVRMHILEETSA--EPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNIL----PVE 192

  Fly   462 KIVKEGLV-------------SFKATSEGLLTRPQHPHSYVTFDDDSLSSESDTRQTPPRLDEAM 513
            ..:||.::             ||...|...|: |:.|.|:.:  ..|:.|..::|.:.|    ..
Mouse   193 SSLKEAIIVGQVNYPKVADSSSFDEDSSDALS-PEQPASHES--QGSVPSPLESRVSDP----LP 250

  Fly   514 VATSSSPTDVLQAAAASAGIVTMALTMPTAGQLVVTSPQILPQQQQPKAIVVPAPVPPPPPPPPP 578
            .|||.|||.||..       :.||   |..|:.:..:       :||       |:||.|..||.
Mouse   251 SATSISPTQVLSQ-------LPMA---PDPGETLFLA-------EQP-------PLPPAPLLPPS 291

  Fly   579 LPMASIIKVKQETANLYEELCQSVTGTTASPVNHLYSPCSLASSTSTLSPLSSIASPPPPPMTTT 643
            |...||:                   .||.|
Mouse   292 LANGSIV-------------------PTAKP---------------------------------- 303

  Fly   644 RLHLAPVSVKSDAP--GKDKNRKKSKSKPVS-KARTIKFHEYKGPPSAAGQKQDQTQPE-ETSYQ 704
                ||..:|...|  ..:|:::..|:|.:. |.:.:|:|:|. ||.   ||||:..|. ::||.
Mouse   304 ----APTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYI-PPD---QKQDKGAPAMDSSYA 360

  Fly   705 LMLEQQNCLLKFLENLNKN-----------QSIIPAPSAPGVMLPAAPGATNNSITVTTKTVPAL 758
            .:|:||...|: |:.||:.           |:|:|||..|....|.:
Mouse   361 KILQQQQLFLQ-LQILNQQQQQQQQQHYNYQAILPAPPKPSAETPGS------------------ 406

  Fly   759 ASQSAPAPAPISLPNTISITSS-SGGAPLNFGDATMLTPTPAATPTPPTLSLIAAPQQQLQLHQQ 822
               |||.|:     .::|.:|| |.|           ||.|:......:.:|.|.|
Mouse   407 ---SAPTPS-----RSLSTSSSPSSG-----------TPGPSGLARQSSTALAAKP--------- 443

  Fly   823 HQQLHQPTPVQHPPPLPSPALSVSSSIPPSPATSYAESTTSSITDLARLEKMKVSDLKQHLKRRN 887
                                    .::|                  |.|:.|||::|||.||.|:
Mouse   444 ------------------------GALP------------------ANLDDMKVAELKQELKLRS 466

  Fly   888 LPVSGPKPHLIERLKPYLPLEPLDSNVTPAPTSNNSNTTPEVITISDAMDTSNCGLLEQPPPVTM 952
            |||||.|..|||||:.|      ...|:|||.:..:..|..|:        |..|.:....|..:
Mouse   467 LPVSGTKTELIERLRAY------QDQVSPAPGAPKAPATTSVL--------SKAGEVVVAFPAAL 517

  Fly   953 LVSDASMEHEQMDVVQQQMDNTHPMTLQTILPPQPQTATIILTNEELLREQQRKIDELQRQLQRS 1017
            |
Mouse   518 L---------------------------------------------------------------- 518

  Fly  1018 QQELQKIRQRQQQQQHQQQQTVTAQVVNALPSQQITLITTTSNG------PQQTLTVMPQQVEKN 1076
                               .|.:|.|...|...::.:.|.||||      ...|..|.|.
Mouse   519 -------------------STGSALVTAGLAPAEMVVATVTSNGMVKFGSTGSTPPVSPT----- 559

  Fly  1077 FPAKVTVKATGGNSNHKVNGLQQQGSAAKKPASSNSNSNSNISSSNPPPINQKMVVKQQLEAKIQ 1141
             |::.::.:||                     ..||............|:.|  :..|....:|.
Mouse   560 -PSERSLLSTG---------------------DENSTPGDAFGEMVTSPLTQ--LTLQASPLQIV 600

  Fly  1142 KQKAAAAAA--------AQQQQQQQQQQQQQQQQQALQQQQQQQQQQQQVRLLTQKTQTVFIPFN 1198
            |::.|.||:        |:.:...:.|..|::.:|..:..:..||:||.|.||
Mouse   601 KEEGARAASCCLSPGARAELEGLDKDQMLQEKDKQIEELTRMLQQKQQLVELL------------ 653

  Fly  1199 NNNHINNASAKTTTKKSNVPANNTNTTTATMMQAAKPAAVAAAAASPGNQHHNNLGLLWNEGNQT 1263
                                        ...::..|.|...|.|:||          :..|...:
Mouse   654 ----------------------------RLQLEQQKRAQQPAPASSP----------VKRESGFS 680

  Fly  1264 ILLLGLNDQHMTAHTLGNISLTATTT---TTAAPPAATPVAAS--------TIAPPKKILNGHQR 1317
            ...|....|. :||..|:..:..||.   |.|..|.:.||...        .:||..::|.|.|.
Mouse   681 SCQLSCQPQG-SAHAFGSGLVVPTTNHGDTQAPAPESPPVVVKQEAGPPEPDLAPSSQLLLGSQG 744

  Fly  1318 TNSLPSIVFP-IETKSIITQQQLQQLQQQQQQQQQFQPVQQPKQQQLNQVDIKPAPAP------- 1374
            |:.|..:..| :.|.|  |...|......:.......|...| ||.|:|.. .|||.|
Mouse   745 TSFLKRVSPPTLVTDS--TGTHLILTVTNKSADGPGLPAGSP-QQPLSQPG-SPAPGPPAQMDLE 805

  Fly  1375 -PPQYEEATKQLAASKAAALNGLLPLVKIKEEP-------VQSPAPSAAPLPQTAPLCKRKTASI 1431
             |||...||               |...:|:||       .|.|              |::....
Mouse   806 HPPQPPFAT---------------PTSLLKKEPPGYEETVTQQP--------------KQQENGS 841

  Fly  1432 KSEQVSDVLDILIKQGEL-----------------PESAALEPITPLTPLPE-LSMFNGATPTTA 1478
            .|:.:.|:.||||:.||:                 |.:||..|  ||||.|. ||....|.|...
Mouse   842 SSQHMDDLFDILIQSGEISADFKEPPSLPGKEKSPPAAAAYGP--PLTPQPSPLSELPQAAPPPG 904

  Fly  1479 AGGASIVPLVP-KLETPVTPVQNLDVAMDTNVQHVGFASNQAPNHVFIESIDMASPLQTDSSAID 1542
            :      |.:| :||..:.....|.:..         :.::.|..:.:.. |:.|.:.:.|:.:|
Mouse   905 S------PTLPGRLEDFLESSTGLPLLT---------SGHEGPEPLSLID-DLHSQMLSSSAILD 953

  Fly  1543 -AESVAKTLDIFLEQHHATPPPSTPPKSCHSGSEKPNSPDAKLNHFDEYELLELMS 1597
             ..|...|.::     |..|.||       ||.    ..|..:.|.|..:.|||.|
Mouse   954 HPPSPMDTSEL-----HFAPEPS-------SGM----GLDLAVGHLDSMDWLELSS 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrtf	NP_001137879.3	RPEL	387..412	CDD:128947	15/24 (63%)
		RPEL	433..458	CDD:128947	14/24 (58%)
		SAP	871..905	CDD:280251	21/33 (64%)
Mrtfa	NP_001076005.2	RPEL	81..105	CDD:128947	11/23 (48%)
		RPEL	124..149	CDD:128947	15/24 (63%)
		RPEL	168..193	CDD:128947	15/28 (54%)
		SAP	453..483	CDD:334796	20/29 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836912
Domainoid	1	1.000	49	1.000	Domainoid score	I11715
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3836
Isobase	1	0.950	-	0	Normalized mean entropy	S8133
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104701
Panther	1	1.100	-	-	LDO	PTHR22793
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2343
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.930