Protein Alignment Fife and Rims2

DIOPT Version :10

• Sequence 1: NP_001261340.1
• Gene: Fife / 38337
• FlyBaseID: FBgn0264606
• Length: 1314
• Species: Drosophila melanogaster
• Sequence 2: XP_038934192.1
• Gene: Rims2 / 116839
• RGDID: 620001
• Length: 1726
• Species: Rattus norvegicus
• Alignment Length: 1667
• Identity: 364/1667 - (21%)
• Similarity: 561/1667 - (33%)
• Gaps: 577/1667 - (34%)

  Fly    84 QSQQQQQQDYGSSLNNNNNNSSGGGTATTGGGGGGAAAKQEPGRRAGACRVCLKSFKPDDYHKTC 148
            :|||||:|.               |.|.|                   |.:|.|:...|.....|
  Rat   162 ESQQQQEQK---------------GDAPT-------------------CGICHKTKFADGCGHNC 192

  Fly   149 FECQQRVCEDCASYSKL--DEHEDATMWRCSVCRRKMA-----------SRVCIPQDSTDSML-- 198
            ..||.:.|..|.....|  ::.:...||.|::||::..           |....||......|
  Rat   193 SYCQTKFCARCGGRVSLRSNKEDKVVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKALRG 257

  Fly   199 ---------------------------DVPVLE-----ALQRRHSDAKLGS-------------- 217
                                       .||.:|     .|.|:.| .|.||
  Rat   258 LRSEEAPQEKKAKLHEQTQFQGPPGDSSVPAVERGRAHGLTRQDS-IKNGSGMKHQIASDMPSDR 321

  Fly   218 ------------------------------STQTLAPSNGAALAPPRSPEL-------------- 238
                                          ||...:||:.|.....|.|:.
  Rat   322 KRSPSVSRDQNRRYDQSEEREEYSQYVPSDSTMPRSPSDYADRRSQREPQFYEEPDHLNYRDSNR 386

  Fly   239 ----------------------------------------------------------------- 238
                                                                             
  Rat   387 RGHRHSKEYIVDDEDVESRDEYERQRREEEYQARYRSDPNLARYPVKPQPYEEQMRIHAEVSRAR 451

  Fly   239 --RRHSDVSPA---------SLKELERQLK-------------------------GGRSMAPSR- 266
              |||||||.|         ||..::|..:                         .|:|..|.|
  Rat   452 HERRHSDVSLANAELEDSRISLLRMDRPSRQRSVSERRAAMENQRSYSMERTREAQGQSSYPQRT 516

  Fly   267 -SNSPPRGEGPDGQPPFGAPLSRMQSRRGSRVARQHSYD----------DDMKTGPVGGSMGGGG 320
             ::|||.   |...|   .||.|.:.||...:.:||..|          :.|:|.....|
  Rat   517 TNHSPPT---PRRSP---IPLDRPELRRADSLRKQHHLDPSSAVRKTKREKMETMLRNDS----- 570

  Fly   321 PALGLGADGAGLGIPTMPR-RKSAYDVFAPGLTQGGATPATQLQRSPGEGGIMPPIQLPGSRRPS 384
                |.:|.:....|..|| .||.                        :||.|..:.|..|....
  Rat   571 ----LSSDQSESVRPPPPRPHKSK------------------------KGGKMRQVSLSSSEEEL 607

  Fly   385 FRVP-HPSEDIQNDDSPGSPDKGSPVLTVDDDRRMRRRGSQLPDIAMLQNRGALPAVPPSSIPPP 448
            ...| :.|.|....:|....:||       |.::.:|:.|:....:....|        |.....
  Rat   608 ASTPEYTSCDDVEIESESVSEKG-------DSQKGKRKTSEQAVWSDSNTR--------SERQKK 657

  Fly   449 MASFTGPNL-EDLEAPRRQTSMDG-----------EAIRIVIHDVDSGPICASKR---RIILRRD 498
            :....|.:| ||||....||...|           |......|.|...|.....|   ||:|.:.
  Rat   658 VMYSGGHSLDEDLEWSEPQTKDSGVDTCSSTTLNEERSHSDEHPVTWQPSKDGDRLIGRILLNKR 722

  Fly   499 PTD-KAHRTRG--FGMRVVGGKTGADGRLFAYIVWTVPGGAAEKNG-LQQGDKILEWNGMSLIDR 559
            ..| ...|..|  .|::|||||....|||.|:|.....|..|:..| |:.||::|||||..|...
  Rat   723 LKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGA 787

  Fly   560 SFEEVCSIM--DRTGDVVELLVEHAT-DF-RMCDLFDENLPPGNAGGQS----GPRRSGDGPVGL 616
            :||||.:|:  .:....|||:|.... |. |:.|.....|...::..:|    .|..|...|:..
  Rat   788 TFEEVYNIILESKPEPQVELVVSRPIGDMPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSP 852

  Fly   617 GLIAE-PETTTDK-SPASPTRRKLPKTPEQIAREKLVTGRVQIQVWYHAERSELVVSLMAGDDLA 679
            |::.: |:..:.: |..|.:||..|..|           ||||::|:.....:|:|:::...||.
  Rat   853 GMLRDVPQFLSGQLSSQSLSRRTTPFVP-----------RVQIKLWFDKVGHQLIVTILGAKDLP 906

  Fly   680 PRDEAYGHGNLPEAYAKVRILPKCGDGSVQQTEVSRPTQNPIWNATLTFGHVKADTLMVRYIDIQ 744
            .|::    |.....|.|:..||...|.:.::|:..:.|..|.||.|..:..|.......|.::|.
  Rat   907 SRED----GRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT 967

  Fly   745 LWD--LVPHTESIFLGECSIELQQAFLDDQAIWCRLEDTKGLRGISISKSPSVSPRGSI------ 801
            |||  .|...||.||||..|||:.|.|||:..|.:|: |..:..:.:.......||..:
  Rat   968 LWDQARVREEESEFLGEILIELETALLDDEPHWYKLQ-THDVSSLPLPHPSPYMPRRQLHGESPT 1031

  Fly   802 -----AAGAGAPSGDVTRLLRRDYNMQRSNSDDVDSIG-------DG-----TSLLHPDHAWIAG 849
                 .|.....||.     :|..:.:.|:.|..|.:|       ||     ::|..|:.  :..
  Rat  1032 RRLQNKALCSCSSGS-----KRISDSEVSDYDCEDGVGVVSDYRHDGRDLQSSTLSVPEQ--VMS 1089

  Fly   850 SRRGSSQSETMEVEVYQLGKDFSRSLP------------GSRRSSFQDA----EKNRLEEDAMAT 898
            |...|.......|:|....:.:|.|:|            |:|.:...:.    :::|:.:|..::
  Rat  1090 SNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRATGHYNTISRMDRHRVMDDHYSS 1154

  Fly   899 PPTSYLV-----------------GR--------------------------RRSSVARRDPDEI 920
            ...|:.:                 ||                          .||..:.|....:
  Rat  1155 ERDSHFLTLPRSRHRQTSEHHHRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSSERADTNL 1219

  Fly   921 LKSLKAVRGELGRTMSLG---TEQHKRMGSRRAS--------RVG--LPSGP------------- 959
            ::|:.::.  .||:....   :..|.|.||.:.|        |.|  ||..|
  Rat  1220 MRSMPSLM--TGRSAPPSPALSRSHPRTGSVQTSPSSTPVTGRRGRQLPQLPPKGTLERMITEDM 1282

  Fly   960 -SSRK--SSVLDLSQQHQQ-QLQQLQQL-----QLQQQQYLQQQLPMGVG-----NADT-SPPSE 1009
             |:||  |..:|:.::::| :|.:.:|:     :|:|..:.:.:    .|     .||| |..|.
  Rat  1283 DSTRKRNSGAMDIEERNRQMKLNKYKQVAGSDPRLEQDYHSKYR----SGWDPHRGADTVSTKSS 1343

  Fly  1010 DED-------------KRY-----------RPRWKGSVS----------QLPPQSP--------- 1031
            |.|             .|:           |||....:|          |.|.|.|
  Rat  1344 DSDVSDVSAVSRTSSASRFSSTSYMSVQSERPRGNRKISFSPLVQECGAQAPVQPPLIPLGPDIN 1408

  Fly  1032 --KQALSRLKQAASASNVAQDTQRQGQL--LTTNPLQQRKSSMFQLG------ESQASPPTTTTT 1086
              ...:...:...|..::|:.|...|.:  |..|...|..:::..||      .|..........
  Rat  1409 VFTSKMQSRQMGVSGKSMAKSTSISGDMCSLEKNDGSQSDTAVGALGTSGKKRRSSIGAKMVAIV 1473

  Fly  1087 HLQRKGSMYVAKVTETPPHGTPTRKGSVYQRSV-VGLSVDSPGADSPQRKQSVVKTLSGSYVN-- 1148
            .|.|| |...:::::|...|...|  |..|||. .||:|:.....:.|..:........||.:
  Rat  1474 GLSRK-SRSASQLSQTEGGGKKLR--STVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEG 1535

  Fly  1149 --ICP-------------LTGGESSYGLKLGPSQIHPKGYRLTTARYGELKMGFLKIKGNVEVEL 1198
              |.|             |.|        |||:|:..: ..|.|...|::::|.:..||.:|||:
  Rat  1536 NLIFPGVRLASDSQFSDFLDG--------LGPAQLVGR-QTLATPAMGDIQVGMMDKKGQLEVEI 1591

  Fly  1199 ICARN-IVNEDCETPPDTYVKCYIKDGDRLRHKKKTRVVRHAAEPLYRQTIKYQSSDVFGRNIVI 1262
            |.||. :|....:|.|..|||.|:.|......||||:|.|...||||:|.:.::.|.. |:.:.|
  Rat  1592 IRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQ-GKVLQI 1655

  Fly  1263 MVWQRCVGFEHNQGLGGTEVNLDKLSIGQPISGWYPLFPMHS 1304
            :||......:|...:|..::.||:|.:...:.||:.|||..|
  Rat  1656 IVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSS 1697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fife	NP_001261340.1	FYVE_BSN_PCLO	130..187	CDD:277290	16/69 (23%)
		PDZ_RIM-like	487..580	CDD:467198	38/101 (38%)
		C2A_RIM1alpha	651..779	CDD:175997	43/129 (33%)
		C2	1163..1304	CDD:472691	50/141 (35%)
Rims2	XP_038934192.1	BRcat_Rcat_RBR	174..206	CDD:459240	10/50 (20%)
		FYVE_like_SF	<192..240	CDD:333710	11/47 (23%)
		PDZ_RIM-like	711..810	CDD:467198	38/98 (39%)
		C2A_RIM1alpha	881..1004	CDD:175997	43/126 (34%)
		C2B_RIM1alpha	1557..1702	CDD:175994	51/143 (36%)