DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ProRS-m and SPBC24C6.03

DIOPT Version :9

Sequence 1:	NP_647737.1	Gene:	ProRS-m / 38331	FlyBaseID:	FBgn0027082	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_595957.1	Gene:	SPBC24C6.03 / 2540642	PomBaseID:	SPBC24C6.03	Length:	425	Species:	Schizosaccharomyces pombe

Alignment Length:	396	Identity:	153/396 - (38%)
Similarity:	235/396 - (59%)	Gaps:	15/396 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SQKLLTELGLVKSGSNGTYQIMPMAQRSVDKCIDLVQSNMQQAGGQKITLPILTPTGLWKKTGRL 93
            :.:||.::|.::....|.:|.:|:..|..:|..||:..:|:..|...|:|..|:...:|:|:||.
pombe    27 ANQLLIDMGFIQPSMPGIFQYLPLGLRVQNKICDLLHISMRSLGASAISLAHLSSKEIWEKSGRW 91

  Fly    94 DGDISEFYMVRDRSGKQFLMSPTHEEAVTAMLATTSPISYRQLPLRLFQIGPKFRDELKTRFGLM 158
            ....||.:.:.||:.::..::|||||.||..:||... |.:|||:|::|||.||||||:.|.||:
pombe    92 QKTGSELFRLHDRNDREMCLAPTHEEDVTRTMATIID-SQKQLPIRVYQIGRKFRDELRPRGGLL 155

  Fly   159 RAKEFLMKDMYSFDVSEETAMETYTLVNAAYDRLFKQLEVPFVKVNAATGIMGGSVSHEYHYVSP 223
            |.:||:|||:|:||:.:.:||:||..|..||...||::.:|||.|.||||.:||::|||:||..|
pombe   156 RGREFMMKDLYTFDIDKASAMKTYEDVLQAYHTFFKEVGLPFVMVKAATGNIGGNLSHEFHYRHP 220

  Fly   224 VGEDNLLQCSSCGFAGNSEVV-----KAPASCPSCNSSDLKEVRGVEVAHTFLLGDKYSKPLGAT 283
            ||||.:..|.||.::.|||::     .:..|||:|| ..|.....:||.|.|.||..||....||
pombe   221 VGEDVIYTCPSCHYSTNSEMLDLSKTSSDISCPNCN-DQLTSTTAIEVGHAFYLGKIYSSKFNAT 284

  Fly   284 FLNTTGKPQSLVMGCYGIGITRVIAAALEVLSSDHELRWPKLLAPYDVCLIGPKQGSKEQPEAEV 348
             :....|.:.|.|||||||::|:|||...|......|.||..:||:.| |:.|...:..| .||.
pombe   285 -VEVKNKQEVLHMGCYGIGVSRLIAAVAHVTKDAKGLVWPSSIAPWKV-LVVPTSDNHIQ-SAET 346

  Fly   349 IENELLLNVGEICGHQELLHDDRKELTIGKRLLEAKRLGHPLTIVVGAKSARLDSPKLEVHTSKG 413
            :.:.    ...:.|...:|.:||:....|.::.:|:.:|:|..||||::.......::.|.:| |
pombe   347 VYDA----TANVVGFDNVLLEDRQNRAFGYKMRDAELIGYPFVIVVGSRFQEEGICEIIVRSS-G 406

  Fly   414 ETYELD 419
            |.|:||
pombe   407 ERYKLD 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ProRS-m	NP_647737.1	PRK09194	3..422	CDD:236405	153/396 (39%)
		ProRS_core_prok	24..313	CDD:238402	122/288 (42%)
		ProRS_anticodon_short	328..428	CDD:238438	26/92 (28%)
SPBC24C6.03	NP_595957.1	ProS	4..420	CDD:223519	153/396 (39%)
		ProRS_core_prok	22..313	CDD:238402	122/288 (42%)
		ProRS_anticodon_short	328..421	CDD:238438	26/92 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	199	1.000	Domainoid score	I668
eggNOG	1	0.900	-	-		E1_COG0442
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5830
Inparanoid	1	1.050	275	1.000	Inparanoid score	I692
OMA	1	1.010	-	-		QHG52122
OrthoFinder	1	1.000	-	-		FOG0004664
OrthoInspector	1	1.000	-	-		oto101359
orthoMCL	1	0.900	-	-		OOG6_103003
Panther	1	1.100	-	-	LDO	PTHR42753
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1453
SonicParanoid	1	1.000	-	-		X3277
TreeFam	1	0.960	-	-
	13	12.860