DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ProRS-m and Pars2

DIOPT Version :9

Sequence 1:	NP_647737.1	Gene:	ProRS-m / 38331	FlyBaseID:	FBgn0027082	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001077356.1	Gene:	Pars2 / 230577	MGIID:	2386296	Length:	511	Species:	Mus musculus

Alignment Length:	440	Identity:	189/440 - (42%)
Similarity:	274/440 - (62%)	Gaps:	21/440 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KASRIFCPALITPKNAVVKQTEQLS----------RSQKLLTELGLVKSGSNGTYQIMPMAQRSV 57
            :..|:....:..|:|  :::.:.||          :||:|:.::||:...|.|.|.:||...|:|
Mouse    72 RGQRLVLSRMFQPQN--LREDQVLSLEGRASDLTCKSQRLMLQVGLILPASPGCYHLMPYTVRAV 134

  Fly    58 DKCIDLVQSNMQQAGGQKITLPILTPTGLWKKTGRLDGDISEFYMVRDRSGKQFLMSPTHEEAVT 122
            :|.:.::...||..|||||.:|.|:|..||:.|.|.|....|...:|||.||::.:.||||||||
Mouse   135 EKLVRVIDQEMQAIGGQKINMPSLSPAELWRATSRWDLMGRELLRLRDRHGKEYCLGPTHEEAVT 199

  Fly   123 AMLATTSPISYRQLPLRLFQIGPKFRDELKTRFGLMRAKEFLMKDMYSFDVSEETAMETYTLVNA 187
            |::|:...:||:||||.|:|:..|||||.:.||||:|.:||.|||||:||.|.|.|.|||.||..
Mouse   200 ALVASQKKLSYKQLPLLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSSEAAQETYGLVCD 264

  Fly   188 AYDRLFKQLEVPFVKVNAATGIMGGSVSHEYHYVSPVGEDNLLQCSSCGFAGNSEVVK-APASCP 251
            ||.|||.:|.:.::|..|..|.:||::|||:.....:|||.|:.|.||.|:.|:|::. :...||
Mouse   265 AYCRLFDRLGLQWMKARADVGSIGGTMSHEFQLPVDIGEDRLVVCPSCHFSANTEILDLSQKICP 329

  Fly   252 SCNSSDLKEVRGVEVAHTFLLGDKYSKPLGATFLNTTGKPQSLVMGCYGIGITRVIAAALEVLSS 316
            .| ...|.|.:|:||.|||.|..|||....|.|.|..|:.....|||||:|:||::|||:||||:
Mouse   330 DC-QGPLTETKGIEVGHTFYLSTKYSSIFNALFTNAHGESLLAEMGCYGLGVTRILAAAIEVLST 393

  Fly   317 DHELRWPKLLAPYDVCLIGPKQGSKEQPEAEVIE---NELLLNVGEICGHQELLHDDRKELTIGK 378
            :..:|||:|||||.||:|.||:||||....|::|   ::::..|.::.|  |:|.|||..||||.
Mouse   394 EDCIRWPRLLAPYQVCVIPPKKGSKETAATEIVEKLYDDIMEAVPQLRG--EVLLDDRTHLTIGN 456

  Fly   379 RLLEAKRLGHPLTIVVGAKSARLDSPKLEVHT-SKGETYELDFSETLKLV 427
            ||.:|.:||:|..|:.| |.|..|....||.: :.||...|.....::|:
Mouse   457 RLKDANKLGYPFVIIAG-KRALEDPAHFEVWSQNTGEVVFLTKEGVMELL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ProRS-m	NP_647737.1	PRK09194	3..422	CDD:236405	188/433 (43%)
		ProRS_core_prok	24..313	CDD:238402	135/299 (45%)
		ProRS_anticodon_short	328..428	CDD:238438	41/104 (39%)
Pars2	NP_001077356.1	PRK09194	78..506	CDD:236405	188/434 (43%)
		ProRS_core_prok	101..390	CDD:238402	133/289 (46%)
		ProRS_anticodon_short	405..506	CDD:238438	41/104 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840042
Domainoid	1	1.000	216	1.000	Domainoid score	I2696
eggNOG	1	0.900	-	-		E1_COG0442
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5830
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2275
Isobase	1	0.950	-	0	Normalized mean entropy	S2325
OMA	1	1.010	-	-		QHG52122
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004664
OrthoInspector	1	1.000	-	-		oto93759
orthoMCL	1	0.900	-	-		OOG6_103003
Panther	1	1.100	-	-	LDO	PTHR42753
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1453
SonicParanoid	1	1.000	-	-		X3277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740