DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIFC1 and kifc1

DIOPT Version :9

Sequence 1:	XP_016866325.1	Gene:	KIFC1 / 3833	HGNCID:	6389	Length:	674	Species:	Homo sapiens
Sequence 2:	XP_002938712.2	Gene:	kifc1 / 100038104	XenbaseID:	XB-GENE-489355	Length:	650	Species:	Xenopus tropicalis

Alignment Length:	659	Identity:	297/659 - (45%)
Similarity:	393/659 - (59%)	Gaps:	58/659 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    26 SQLPLSGSRLK----RRPDQMEDGLEPEKKRTRG--------LGATTKITTSHPRVPSLTTVPQT 78
            |:||:...|.:    ...:||:...:.:.||.|.        :.....|.||.||...:..:|:.
Frog    13 SRLPVPPKRKRVLSDENQEQMQRVTKEKGKRLRSSLEAELPTVRVAASIATSRPRAAPIAALPKP 77

Human    79 Q---GQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTSGVPPMA--GGKKPSKRPAWD 138
            |   .|:.|....|.:.|..::|..:|    ||       |...|...|.|  |.||  ||.|||
Frog    78 QVIGRQSLAVIRPKNSIPGVTSAAFSG----KP-------KVSASATQPAAISGDKK--KRAAWD 129

Human   139 LKGQLCDLNAELKRCRERTQTLDQENQQLQDQ----LRDAQ---QQVKALGTERTTLEGHLAKVQ 196
            ||||:.|:..::...:.:.|.|..||.:||:.    |||.:   .:...|..||.|||..|.:|:
Frog   130 LKGQVSDMRDKVTNYKGKVQNLSGENVRLQNSKDKLLRDVEMLTSENTKLSKERCTLESQLQEVR 194

Human   197 AQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEERRGLMSQLEEKERRLQTSEAA 261
            .|....::|:..|.......|..||:|...::|||.....|.:       ||.:|:.:|......
Frog   195 QQVSALEREVARLTELCQRQEHTLSSQSISIEELQGANTSLTK-------QLLDKDVKLVCVSGE 252

Human   262 LSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRLHNQLQELKGNIRVFCRVRPVLPGEPT 326
            .:|.:..|.....|..|....:.|::..:|.|:.|||||||.:|||||||||||||||.|..|..
Frog   253 NTSLKHTVKEQTDEIAALTVSVAEKDTEVHNLDTERRRLHNLVQELKGNIRVFCRVRPTLTQEKE 317

Human   327 PPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEI 391
            .|.|.:.:      ||:....:.||:.:|..  :........::||:||.||||...|:.|||||
Frog   318 LPAGHISY------PSNDDKAVVLSKMEESH--VGREKKDAVKYDFNFDCVFPPSCSQESVFEEI 374

Human   392 AMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYS 456
            ::||||||||||||||||||||||||:||||.........|:||||:..:||.|:||..:||.::
Frog   375 SLLVQSALDGYPVCIFAYGQTGSGKTYTMEGPEDITDDTIGMIPRAIGQIFSSAEELKAKGWQFT 439

Human   457 FVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLAR 521
            |.||::||||||:||||.  .|..:..|.|||:....:.:|.|||.|||.||..:||..||.:|:
Frog   440 FTASFLEIYNETLRDLLI--NRPDKKLEYEIRKVNSSNSQLYVTNLRYVEVSSVEEVHDLLRIAK 502

Human   522 QNRAVARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERL 586
            .||:||:||.|:|||||||||||:|.||:..|.|:..:.|||:|||||||||..|:.|    :||
Frog   503 ANRSVAKTAINDRSSRSHSVFQLRIEGENKQRDLKTSSVLSLIDLAGSERLDRSLSSG----DRL 563

Human   587 RETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESL 651
            :|||.||:||||||:||.:|.||:||:|||||||||||||||||:||:||||||||||||.:|||
Frog   564 KETQCINTSLSTLGMVITSLCNKDSHIPYRNSKLTYLLQNSLGGNAKVLMFVNISPLEENFAESL 628

Human   652 NSLRFASKV 660
            |||||||||
Frog   629 NSLRFASKV 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIFC1	XP_016866325.1	SPEC	<145..294	CDD:295325	39/155 (25%)
		SlyX	215..268	CDD:294687	13/52 (25%)
		Microtub_bd	297..>317	CDD:293401	17/19 (89%)
		KISc_C_terminal	308..661	CDD:276817	207/353 (59%)
		KISc	310..661	CDD:214526	205/351 (58%)
kifc1	XP_002938712.2	Mplasa_alph_rch	<121..>287	CDD:275316	51/174 (29%)
kifc1	XP_002938712.2	KISc_C_terminal	299..642	CDD:276817	207/353 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	359	1.000	Domainoid score	I7107
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83229
Inparanoid	1	1.050	499	1.000	Inparanoid score	I7692
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53834
OrthoDB	1	1.010	-	-		D111827at32523
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	1	1.000	-	-		oto148535
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2170
SonicParanoid	1	1.000	-	-		X1242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010