DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP-1 and Zfp423

DIOPT Version :9

Sequence 1:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001380647.1	Gene:	Zfp423 / 94188	RGDID:	621664	Length:	1292	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	144/740 - (19%)
Similarity:	233/740 - (31%)	Gaps:	214/740 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 ESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLSALKVAIKPAAALATA 593
            ||...:|..|..::..|..|.::.:|||:|..:..:.|   ......|..:|       |.|...
  Rat    39 ESECDRKTSRALEDRNSVTSQEERNEDDEDVEDESIYT---CDHCQQDFESL-------ADLTDH 93

  Fly   594 GGVSVNNPGGNKPGQENYFESPLGKFF----------MDIGVGLVQ---------EYVQSDLLRL 639
            ........|.:.|.......||..|..          .|:|:|..:         ::.....:||
  Rat    94 RAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRL 158

  Fly   640 QKRKMRKAQVQNSKEFEMAINALSGNLQASKTKNAPFKFRMKRCEFCN--FK------------- 689
            ...| |..|:.:.|                    .|||     |.||:  ||
  Rat   159 SYLK-RHEQIHSDK--------------------LPFK-----CTFCSRLFKHKRSRDRHIKLHT 197

  Fly   690 ---------SESAMAMANHYE---TPHMNGVLYKCNFCTFEIRNATEIVYHMEAVHNIKARLIK- 741
                     .|:|.:.::|.:   ..|.:...:||:.|.....:.:.:..||:|....|..|.|
  Rat   198 GDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKS 262

  Fly   742 ----PLPYHQCPNCGFEDNGKAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGT 802
                ......|..|....:...:|.:|    .....|:|:        ..|.:..|......|..
  Rat   263 EKEAKKDDFMCDYCEDTFSQTEELEKH----VLTLHPQLS--------EKADLQCIHCPEVFVDE 315

  Fly   803 ATAYQAMAAQAAAQKAALANIQQQQAAAQARNNLQAAALAAQNAAKMR------QRAPQPPKQNI 861
            :|              .||:|.|..|     |......:..:..:.:.      ....||...|.
  Rat   316 ST--------------LLAHIHQAHA-----NQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNH 361

  Fly   862 VRNPAPVRGGNAMNAGLSLPNSYQLAAGQLVQASKKPMAGQPSISITPLPRQSSVGAGAGASSSK 926
            ..:|.||.|..|..:..:..:|..:..|....::.||:.||..:            ...|.|.||
  Rat   362 SVSPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKM------------RDDGQSWSK 414

  Fly   927 APQAAA---------------------GMKPGQSPSGNNKAQFVICEICDGYIKDLEQLRNHMQW 970
            ...:..                     ..||.||.:         |:||...:..|..|..|::.
  Rat   415 VVYSCPYCSKRDFTSLAVLEIHLKTIHADKPQQSHT---------CQICLDSMPTLYNLNEHVRK 470

  Fly   971 MHKVKIHPKMIY-NRPPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVC- 1033
            :||...:|.|.: |....:|..|...|.....|:.|:..||....::..:    |.:|..|..|
  Rat   471 LHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPPD----GNNAFFCNQCS 531

  Fly  1034 -GRMYQWKLLNHVSRDH---------HMTLKPAHL---SYKCTVCTAT--FGMYKQFETHVYTAH 1083
             |.:.:..|..|:.:.|         ...::|...   .|.|..||.:  ||...:...|:...|
  Rat   532 MGFLTESSLTEHIQQAHCSVGSTKLESPVIQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENH 596

  Fly  1084 STVARKAMDSKKNSAQSSGSGSGAGMS---RSSL-GAAN-------------------DSLLKPL 1125
            ..:  ....|||:.|:.|...|...:|   |..| |:||                   :|....|
  Rat   597 KNI--PLAHSKKSKAEQSPVSSDVEVSSPKRQRLSGSANSISNGEYPCNQCDLKFSNFESFQTHL 659

  Fly  1126 KINDEITIIPQ--PASKPRITNMES 1148
            |::.|:.:..|  |..|....:.||
  Rat   660 KLHLELLLRKQACPQCKEDFDSQES 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165
		C2H2 Zn finger	951..977	CDD:275371	8/25 (32%)
		C2H2 Zn finger	989..1010	CDD:275371	5/20 (25%)
Zfp423	NP_001380647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..70		10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..123		5/27 (19%)
		C2H2 Zn finger	148..168	CDD:275368	5/20 (25%)
		C2H2 Zn finger	176..196	CDD:275368	5/19 (26%)
		COG5048	202..603	CDD:227381	86/458 (19%)
		C2H2 Zn finger	204..224	CDD:275368	3/19 (16%)
		C2H2 Zn finger	232..252	CDD:275368	4/19 (21%)
		C2H2 Zn finger	273..292	CDD:275368	4/22 (18%)
		C2H2 Zn finger	419..440	CDD:275368	0/20 (0%)
		C2H2 Zn finger	451..475	CDD:275368	8/23 (35%)
		C2H2 Zn finger	490..509	CDD:275368	5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..635		12/38 (32%)
		C2H2 Zn finger	672..692	CDD:275368	4/13 (31%)
		C2H2 Zn finger	702..723	CDD:275368
		C2H2 Zn finger	730..751	CDD:275368
		C2H2 Zn finger	760..781	CDD:275368
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	817..835	CDD:275368
		C2H2 Zn finger	896..917	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		C2H2 Zn finger	969..989	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1144..1171
		C2H2 Zn finger	1208..1228	CDD:275368
		C2H2 Zn finger	1239..1260	CDD:275368
		C2H2 Zn finger	1269..1285	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100